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1000 Titel
  • Helminth antigens differentially modulate the activation of CD4(+) and CD8(+) T lymphocytes of convalescent COVID-19 patients in vitro
1000 Autor/in
  1. Adjobimey, Tomabu |
  2. Meyer, Julia |
  3. Terkes, Vedrana |
  4. Parcina, Marijo |
  5. Hoerauf, Achim |
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-06-28
1000 Erschienen in
1000 Quellenangabe
  • 20:241
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12916-022-02441-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241220/ |
1000 Ergänzendes Material
  • https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02441-x#Sec18 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly, causing millions of death worldwide. Contrary to the predictions, prevalence and mortality due to COVID-19 have remained moderate on the African continent. Several factors, including age, genetics, vaccines, and co-infections, might impact the course of the pandemic in Africa. Helminths are highly endemic in Sub-Saharan Africa and are renowned for their ability to evade, skew, and suppress human immune responses through various immune-modulatory mechanisms. Such effects will likely impact SARS-CoV-2 transmission and disease progression. METHODS: Here, we analyzed in vitro the impact of antigen extracts from three major helminth parasites, including Onchocerca volvulus, Brugia malayi, and Ascaris lumbricoides, on the immune reactivity to SARS-CoV-2 peptides in COVID-19 patients. Activation of CD4+ and CD8+ T cells was investigated using flow cytometry to monitor the expression of CD137 (4-1BB) and CD69. Cytokine expression, including IL-6, IL-10, IFN-γ, and TNFα, was measured by Luminex in cell culture supernatants. RESULTS: We observed that helminth antigens significantly reduced the frequency of SARS-CoV-2-reactive CD4+ T helper cells. In contrast, the expression of SARS-CoV-2-reactive CD8+ T cells was not affected and even significantly increased when PBMCs from COVID-19 patients living in Benin, an endemic helminth country, were used. In addition, stimulation with helminth antigens was associated with increased IL-10 and a reduction of IFNγ and TNFα. CONCLUSION: Our data offer a plausible explanation for the moderate incidence of COVID-19 in Africa and support the hypothesis that helper T cell-mediated immune responses to SARS-CoV-2 are mitigated in the presence of helminth antigens, while virus-specific cytotoxic T cell responses are maintained.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal CD4+ helper and CD8+ T cytotoxic T cells
lokal CD69
lokal CD137 (4-1BB)
lokal Helminth antigens
lokal activation markers
lokal SARS-CoV-2
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0002-4353-2897|https://frl.publisso.de/adhoc/uri/TWV5ZXIsIEp1bGlh|https://frl.publisso.de/adhoc/uri/VGVya2VzLCBWZWRyYW5h|https://frl.publisso.de/adhoc/uri/UGFyY2luYSwgTWFyaWpv|https://frl.publisso.de/adhoc/uri/SG9lcmF1ZiwgQWNoaW0=
1000 Label
1000 Förderer
  1. Project DEAL |
  2. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. -
  2. EXC2151—390873048
1000 Förderprogramm
  1. Open access funding
  2. Germany’s Excellence Strategy
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Project DEAL |
    1000 Förderprogramm Open access funding
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm Germany’s Excellence Strategy
    1000 Fördernummer EXC2151—390873048
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6438141.rdf
1000 Erstellt am 2022-10-26T12:17:44.078+0200
1000 Erstellt von 329
1000 beschreibt frl:6438141
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Tue Mar 28 11:24:33 CEST 2023
1000 Objekt bearb. Fri Nov 11 17:34:21 CET 2022
1000 Vgl. frl:6438141
1000 Oai Id
  1. oai:frl.publisso.de:frl:6438141 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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