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1000 Titel
  • Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels
1000 Autor/in
  1. Van der Kooij, Michael A |
  2. Rojas-Charry, Liliana |
  3. Givehchi, Maryam |
  4. Wolf, Christina |
  5. Bueno, Diones |
  6. Arndt, Sabine |
  7. Tenzer, Stefan |
  8. Mattioni, Lorenzo |
  9. Treccani, Giulia |
  10. Hasch, Annika |
  11. Schmeisser, Michael J. |
  12. Vianello, Caterina |
  13. Giacomello, Marta |
  14. Methner, Axel |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-08-09
1000 Erschienen in
1000 Quellenangabe
  • 100(10):1441-1453
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00109-022-02235-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470722/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Chronic stress has the potential to impair health and may increase the vulnerability for psychiatric disorders. Emerging evidence suggests that specific neurometabolic dysfunctions play a role herein. In mice, chronic social defeat (CSD) stress reduces cerebral glucose uptake despite hyperglycemia. We hypothesized that this metabolic decoupling would be reflected by changes in contact sites between mitochondria and the endoplasmic reticulum, important intracellular nutrient sensors, and signaling hubs. We thus analyzed the proteome of their biochemical counterparts, mitochondria-associated membranes (MAMs) from whole brain tissue obtained from CSD and control mice. This revealed a lack of the glucose-metabolizing enzyme hexokinase 3 (HK3) in MAMs from CSD mice. In controls, HK3 protein abundance in MAMs and also in striatal synaptosomes correlated positively with peripheral blood glucose levels, but this connection was lost in CSD. We conclude that the ability of HK3 to traffic to sites of need, such as MAMs or synapses, is abolished upon CSD and surmise that this contributes to a cellular dysfunction instigated by chronic stress.
1000 Sacherschließung
lokal Mitochondria
lokal Brain
lokal Hexokinase
lokal Stress
lokal Mice
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/VmFuIGRlciBLb29paiwgTWljaGFlbCBB|https://frl.publisso.de/adhoc/uri/Um9qYXMtQ2hhcnJ5LCBMaWxpYW5h|https://frl.publisso.de/adhoc/uri/R2l2ZWhjaGksIE1hcnlhbQ==|https://frl.publisso.de/adhoc/uri/V29sZiwgQ2hyaXN0aW5h|https://frl.publisso.de/adhoc/uri/QnVlbm8sIERpb25lcw==|https://frl.publisso.de/adhoc/uri/QXJuZHQsIFNhYmluZQ==|https://frl.publisso.de/adhoc/uri/VGVuemVyLCBTdGVmYW4=|https://frl.publisso.de/adhoc/uri/TWF0dGlvbmksIExvcmVuem8=|https://frl.publisso.de/adhoc/uri/VHJlY2NhbmksIEdpdWxpYQ==|https://frl.publisso.de/adhoc/uri/SGFzY2gsIEFubmlrYQ==|https://frl.publisso.de/adhoc/uri/U2NobWVpc3NlciwgTWljaGFlbCBKLg==|https://frl.publisso.de/adhoc/uri/VmlhbmVsbG8sIENhdGVyaW5h|https://frl.publisso.de/adhoc/uri/R2lhY29tZWxsbywgTWFydGE=|http://orcid.org/0000-0002-8774-0057
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1000 Erstellt am 2023-03-03T08:15:46.688+0100
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