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Braitmaier-et-al_2022_Effectiveness of Mammography Screening on Breast Cancer Mortality.pdf 748,39KB
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1000 Titel
  • Effectiveness of Mammography Screening on Breast Cancer Mortality – A Study Protocol for Emulation of Target Trials Using German Health Claims Data
1000 Autor/in
  1. Braitmaier, Malte |
  2. Kollhorst, Bianca |
  3. Heinig, Miriam |
  4. Langner, Ingo |
  5. Czwikla, Jonas |
  6. Heinze, Franziska |
  7. Buschmann, Laura |
  8. Minnerup, Heike |
  9. García-Albéniz, Xabiér |
  10. Hense, Hans-Werner |
  11. Karch, André |
  12. Zeeb, Hajo |
  13. Haug, Ulrike |
  14. Didelez, Vanessa |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-11-02
1000 Erschienen in
1000 Quellenangabe
  • 14:1293-1303
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.2147/CLEP.S376107 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639456/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: The efficacy of mammography screening in reducing breast cancer mortality has been demonstrated in randomized trials. However, treatment options - and hence prognosis – for advanced tumor stages as well as mammography techniques have considerably improved since completion of these trials. Consequently, the effectiveness of mammography screening under current conditions is unclear and controversial. The German mammography screening program (MSP), an organized population-based screening program, was gradually introduced between 2005 and 2008 and achieved nation-wide coverage in 2009. OBJECTIVE: We describe in detail a study protocol for investigating the effectiveness of the German MSP in reducing breast cancer mortality in women aged 50 to 69 years based on health claims data. Specifically, the proposed study aims at estimating per-protocol effects of several screening strategies on cumulative breast cancer mortality. The first analysis will be conducted once 10-year follow-up data are available. METHODS AND ANALYSIS: We will use claims data from five statutory health insurance providers in Germany, covering approximately 37.6 million individuals. To estimate the effectiveness of the MSP, hypothetical target trials will be emulated across time, an approach that has been demonstrated to minimize design-related biases. Specifically, the primary contrast will be in terms of the cumulative breast cancer mortality comparing the screening strategies of “never screen” versus “regular screening as intended by the MSP”. ETHICS AND DISSEMINATION: In Germany, the utilization of data from health insurances for scientific research is regulated by the Code of Social Law. All involved health insurance providers as well as the responsible authorities approved the use of the health claims data for this study. The Ethics Committee of the University of Bremen determined that studies based on claims data are exempt from institutional review. The findings of the proposed study will be published in peer-reviewed journals.
1000 Sacherschließung
lokal emulated target trial
lokal mammography
lokal claims data
lokal effectiveness
lokal cancer screening
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-7534-4068|https://orcid.org/0000-0001-5964-954X|https://frl.publisso.de/adhoc/uri/SGVpbmlnLCBNaXJpYW0=|https://orcid.org/0000-0001-8998-1236|https://frl.publisso.de/adhoc/uri/Q3p3aWtsYSwgSm9uYXM=|https://frl.publisso.de/adhoc/uri/SGVpbnplLCBGcmFuemlza2E=|https://frl.publisso.de/adhoc/uri/QnVzY2htYW5uLCBMYXVyYQ==|https://frl.publisso.de/adhoc/uri/TWlubmVydXAsIEhlaWtl|https://frl.publisso.de/adhoc/uri/R2FyY8OtYS1BbGLDqW5peiwgWGFiacOpcg==|https://orcid.org/0000-0002-7381-1547|https://frl.publisso.de/adhoc/uri/S2FyY2gsIEFuZHLDqQ==|https://orcid.org/0000-0001-7509-242X|https://orcid.org/0000-0002-1886-2923|https://orcid.org/0000-0001-8587-7706
1000 Label
1000 Förderer
  1. Bundesamt für Strahlenschutz |
  2. Bundesministerium für Umwelt, Naturschutz, nukleare Sicherheit und Verbraucherschutz |
  3. Bundesministerium für Gesundheit |
  4. Kooperationsgemeinschaft Mammographie |
  5. National Association of Statutory Health Insurance Funds |
  6. National Association of Statutory Health Insurance Physicians |
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1000 Dateien
1000 Förderung
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    1000 Förderer Bundesamt für Strahlenschutz |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Umwelt, Naturschutz, nukleare Sicherheit und Verbraucherschutz |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Gesundheit |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Kooperationsgemeinschaft Mammographie |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer National Association of Statutory Health Insurance Funds |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer National Association of Statutory Health Insurance Physicians |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6440675.rdf
1000 Erstellt am 2023-03-14T12:13:22.689+0100
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