Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study

  1. Pham, Thu Thi ORCID logo
  2. Nimptsch, Katharina
  3. Aleksandrova, Krasimira ORCID logo
  4. Jenab, Mazda ORCID logo
  5. Reichmann, Robin ORCID logo
  6. Wu, Kana
  7. Tjonneland, Anne ORCID logo
  8. Kyrø, Cecilie ORCID logo
  9. Schulze, Matthias B. ORCID logo
  10. Kaaks, Rudolf
  11. Katzke, Verena
  12. PALLI, Domenico ORCID logo
  13. Pasanisi, Fabrizio ORCID logo
  14. RICCERI, FULVIO ORCID logo
  15. Tumino, Rosario
  16. Krogh, Vittorio ORCID logo
  17. Roodhart, Jeanine
  18. Castilla, Jesus ORCID logo
  19. SANCHEZ-PEREZ, MARIA JOSE ORCID logo
  20. Colorado-Yohar, Sandra ORCID logo
  21. Harbs, Justin
  22. Rutegård, Martin ORCID logo
  23. Papier, Keren ORCID logo
  24. AGLAGO, Elom Kouassivi ORCID logo
  25. Dimou, Niki
  26. Mayén-Chacon, Ana-Lucia
  27. Weiderpass, Elisabete ORCID logo
  28. Pischon, Tobias ORCID logo

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Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study.pdf 332,56KB
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1000 Titel
  • Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study
1000 Autor/in
  1. Pham, Thu Thi |
  2. Nimptsch, Katharina |
  3. Aleksandrova, Krasimira |
  4. Jenab, Mazda |
  5. Reichmann, Robin |
  6. Wu, Kana |
  7. Tjonneland, Anne |
  8. Kyrø, Cecilie |
  9. Schulze, Matthias B. |
  10. Kaaks, Rudolf |
  11. Katzke, Verena |
  12. PALLI, Domenico |
  13. Pasanisi, Fabrizio |
  14. RICCERI, FULVIO |
  15. Tumino, Rosario |
  16. Krogh, Vittorio |
  17. Roodhart, Jeanine |
  18. Castilla, Jesus |
  19. SANCHEZ-PEREZ, MARIA JOSE |
  20. Colorado-Yohar, Sandra |
  21. Harbs, Justin |
  22. Rutegård, Martin |
  23. Papier, Keren |
  24. AGLAGO, Elom Kouassivi |
  25. Dimou, Niki |
  26. Mayén-Chacon, Ana-Lucia |
  27. Weiderpass, Elisabete |
  28. Pischon, Tobias |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-11-09
1000 Erschienen in
1000 Quellenangabe
  • 14(22):5499
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3390/cancers14225499 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688251/ |
1000 Ergänzendes Material
  • https://www.mdpi.com/2072-6694/14/22/5499#app1-cancers-14-05499 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Resistin is a polypeptide implicated in inflammatory processes, and as such could be linked to colorectal carcinogenesis. In case-control studies, higher resistin levels have been found in colorectal cancer (CRC) patients compared to healthy individuals. However, evidence for the association between pre-diagnostic resistin and CRC risk is scarce. We investigated pre-diagnostic resistin concentrations and CRC risk within the European Prospective Investigation into Cancer and Nutrition using a nested case-control study among 1293 incident CRC-diagnosed cases and 1293 incidence density-matched controls. Conditional logistic regression models controlled for matching factors (age, sex, study center, fasting status, and women-related factors in women) and potential confounders (education, dietary and lifestyle factors, body mass index (BMI), BMI-adjusted waist circumference residuals) were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for CRC. Higher circulating resistin concentrations were not associated with CRC (RR per doubling resistin, 1.11; 95% CI 0.94–1.30; p = 0.22). There were also no associations with CRC subgroups defined by tumor subsite or sex. However, resistin was marginally associated with a higher CRC risk among participants followed-up maximally two years, but not among those followed-up after more than two years. We observed no substantial correlation between baseline circulating resistin concentrations and adiposity measures (BMI, waist circumference), adipokines (adiponectin, leptin), or metabolic and inflammatory biomarkers (C-reactive protein, C-peptide, high-density lipoprotein cholesterol, reactive oxygen metabolites) among controls. In this large-scale prospective cohort, there was little evidence of an association between baseline circulating resistin concentrations and CRC risk in European men and women.
1000 Sacherschließung
lokal colorectal cancer
lokal inflammation
lokal pre-diagnostic resistin
lokal prospective
lokal risk
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-2129-0911|https://frl.publisso.de/adhoc/uri/TmltcHRzY2gsIEthdGhhcmluYQ==|https://orcid.org/0000-0002-1275-1827|https://orcid.org/0000-0002-0573-1852|https://orcid.org/0000-0002-1357-5896|https://frl.publisso.de/adhoc/uri/V3UsIEthbmE=|https://orcid.org/0000-0003-4385-2097|https://orcid.org/0000-0002-9083-8960|https://orcid.org/0000-0002-0830-5277|https://frl.publisso.de/adhoc/uri/S2Fha3MsIFJ1ZG9sZg==|https://frl.publisso.de/adhoc/uri/S2F0emtlLCBWZXJlbmE=|https://orcid.org/0000-0002-5558-2437|https://orcid.org/0000-0003-4224-7821|https://orcid.org/0000-0001-8749-9737|https://frl.publisso.de/adhoc/uri/VHVtaW5vLCBSb3Nhcmlv|https://orcid.org/0000-0003-0122-8624|https://frl.publisso.de/adhoc/uri/Um9vZGhhcnQsIEplYW5pbmU=|https://orcid.org/0000-0002-6396-7265|https://orcid.org/0000-0003-4817-0757|https://orcid.org/0000-0002-6700-0780|https://frl.publisso.de/adhoc/uri/SGFyYnMsIEp1c3Rpbg==|https://orcid.org/0000-0002-0974-6373|https://orcid.org/0000-0002-4102-6835|https://orcid.org/0000-0002-0442-3284|https://frl.publisso.de/adhoc/uri/RGltb3UsIE5pa2k=|https://frl.publisso.de/adhoc/uri/TWF5w6luLUNoYWNvbiwgQW5hLUx1Y2lh|https://orcid.org/0000-0003-2237-0128|https://orcid.org/0000-0003-1568-767X
1000 (Academic) Editor
1000 Label
1000 Förderer
  1. Centre International de Recherche sur le Cancer |
  2. NIHR Imperial Biomedical Research Centre |
  3. Kræftens Bekæmpelse |
  4. Ligue Contre le Cancer |
  5. Institut Gustave-Roussy |
  6. Mutuelle Générale de l’Education National |
  7. Institut National de la Santé et de la Recherche Médicale |
  8. Deutsche Krebshilfe |
  9. Deutsches Krebsforschungszentrum |
  10. Bundesministerium für Bildung und Forschung |
  11. Hellenic Health Foundation |
  12. Fondazione AIRC per la ricerca sul cancro ETS |
  13. National Research Council |
  14. Ministerie van Volksgezondheid, Welzijn en Sport |
  15. Netherlands Cancer Registry |
  16. LK Research Funds |
  17. Dutch Prevention Funds |
  18. Zorg Onderzoek Nederland |
  19. World Cancer Research Fund |
  20. Statistics Netherlands |
  21. NordForsk |
  22. Health Research Fund |
  23. Regional Governments of Andalucía, Asturias, Basque Country, Murcia, and Navarra |
  24. Cancerfonden |
  25. Vetenskapsrådet |
  26. Regional Government of Skåne and Västerbotten |
  27. Cancer Research UK |
  28. Medical Research Council |
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1000 Dateien
  1. Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study
    Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Centre International de Recherche sur le Cancer |
    1000 Förderprogramm -
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    1000 Förderer NIHR Imperial Biomedical Research Centre |
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    1000 Förderer Kræftens Bekæmpelse |
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    1000 Förderer Ligue Contre le Cancer |
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    1000 Förderer Institut Gustave-Roussy |
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    1000 Förderer Mutuelle Générale de l’Education National |
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    1000 Förderer Fondazione AIRC per la ricerca sul cancro ETS |
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    1000 Förderer National Research Council |
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    1000 Förderer Ministerie van Volksgezondheid, Welzijn en Sport |
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    1000 Förderer Statistics Netherlands |
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    1000 Fördernummer ISCIII RETIC (RD06/0020)
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    1000 Förderer Cancerfonden |
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1000 Erstellt am 2023-03-17T10:15:36.234+0100
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