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WeightNameValue
1000 Titel
  • Persistent Firing in Hippocampal CA1 Pyramidal Cells in Young and Aged Rats
1000 Autor/in
  1. Brahimi, Yacine |
  2. Knauer, Beate |
  3. Price, Alan Tobias |
  4. Valero Aracama, Maria Jesus |
  5. Reboreda, Antonio |
  6. Sauvage, Magdalena |
  7. Yoshida, Motoharu |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-03-09
1000 Erschienen in
1000 Quellenangabe
  • 10(3):ENEURO.0479-22.2023
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1523/ENEURO.0479-22.2023 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062487/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Persistent neuronal firing is often observed in working memory and temporal association tasks both in humans and animals, and is believed to retain necessary information in these tasks. We have reported that hippocampal CA1 pyramidal cells are able to support persistent firing through intrinsic mechanisms in the presence of cholinergic agonists. However, it still remains largely unknown how persistent firing is affected by the development of animals and aging. Using in vitro patch-clamp recordings from CA1 pyramidal cells in rat brain slices, we first show that the cellular excitability of these aged rats was significantly lower than that of the young rats, responding with fewer spikes to current injection. In addition, we found age-dependent modulations of input resistance, membrane capacitance, and spike width. However, persistent firing in aged (approximately two-year-old) rats was as strong as that in young animals, and the properties of persistent firing were very similar among different age groups. In addition, medium spike afterhyperpolarization potential (mAHP), was not increased by aging and did not correlate with the strength of persistent firing. Lastly, we estimated the depolarization current induced by the cholinergic activation. This current was proportional to the increased membrane capacitance of the aged group and was inversely correlated with their intrinsic excitability. These observations indicate that robust persistent firing can be maintained in aged rats despite reduced excitability, because of the increased amount of cholinergically induced positive current.
1000 Sacherschließung
lokal afterhyperpolarization
lokal aged rats
lokal cholinergic agonist
lokal depolarization current
lokal persistent firing
lokal hippocampus
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-4211-9662|https://frl.publisso.de/adhoc/uri/S25hdWVyLCBCZWF0ZQ==|https://frl.publisso.de/adhoc/uri/UHJpY2UsIEFsYW4gVG9iaWFz|https://frl.publisso.de/adhoc/uri/VmFsZXJvIEFyYWNhbWEsIE1hcmlhIEplc3Vz|https://frl.publisso.de/adhoc/uri/UmVib3JlZGEsIEFudG9uaW8=|https://orcid.org/0000-0002-7586-6410|https://frl.publisso.de/adhoc/uri/WW9zaGlkYSwgTW90b2hhcnU=
1000 Label
1000 Förderer
  1. Ruhr-Universität Bochum |
  2. Wilhelm und Günter Esser Foundation |
  3. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. -
  2. -
  3. YO177/4-1; YO177/4-3
1000 Förderprogramm
  1. International Graduate School of Neuroscience; Rektorat Program
  2. -
  3. -
1000 Dateien
  1. Persistent Firing in Hippocampal CA1 Pyramidal Cells in Young and Aged Rats
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Ruhr-Universität Bochum |
    1000 Förderprogramm International Graduate School of Neuroscience; Rektorat Program
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Wilhelm und Günter Esser Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer YO177/4-1; YO177/4-3
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6441177.rdf
1000 Erstellt am 2023-03-30T11:06:55.160+0200
1000 Erstellt von 242
1000 beschreibt frl:6441177
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2023-07-20T09:50:32.162+0200
1000 Objekt bearb. Tue May 02 07:02:04 CEST 2023
1000 Vgl. frl:6441177
1000 Oai Id
  1. oai:frl.publisso.de:frl:6441177 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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