Genetically programmed changes in transcription of the novel progranulin regulator

  1. Keller, Maria
  2. Gebhardt, Claudia
  3. Huth, Sandra
  4. Schleinitz, Dorit
  5. Heyne, Henrike
  6. Scholz, Markus
  7. Stumvoll, Michael
  8. Böttcher, Yvonne
  9. Tönjes, Anke
  10. Kovacs, Peter ORCID logo

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WeightNameValue
1000 Titel
  • Genetically programmed changes in transcription of the novel progranulin regulator
1000 Autor/in
  1. Keller, Maria |
  2. Gebhardt, Claudia |
  3. Huth, Sandra |
  4. Schleinitz, Dorit |
  5. Heyne, Henrike |
  6. Scholz, Markus |
  7. Stumvoll, Michael |
  8. Böttcher, Yvonne |
  9. Tönjes, Anke |
  10. Kovacs, Peter |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-07-03
1000 Erschienen in
1000 Quellenangabe
  • 98(8):1139-1148
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00109-020-01942-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399677/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Progranulin is a glycoprotein marking chronic inflammation in obesity and type 2 diabetes. Previous studies suggested PSRC1 (proline and serine rich coiled-coil 1) to be a target of genetic variants associated with serum progranulin levels. We aimed to identify potentially functional variants and characterize their role in regulation of PSRC1. Phylogenetic module complexity analysis (PMCA) prioritized four polymorphisms (rs12740374, rs629301, rs660240, rs7528419) altering transcription factor binding sites with an overall score for potential regulatory function of S
1000 Sacherschließung
lokal Transcription, Genetic [MeSH]
lokal Aged [MeSH]
lokal Polymorphism, Single Nucleotide [MeSH]
lokal Progranulins/metabolism [MeSH]
lokal Cell Line [MeSH]
lokal RNA, Messenger/genetics [MeSH]
lokal Genes, Reporter [MeSH]
lokal Original Article
lokal Male [MeSH]
lokal Progranulin
lokal DNA methylation
lokal Gene Expression Regulation [MeSH]
lokal Genetic Variation [MeSH]
lokal RNA, Messenger/metabolism [MeSH]
lokal
lokal Female [MeSH]
lokal Progranulins/genetics [MeSH]
lokal YY1 Transcription Factor/metabolism [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal EMSA
lokal Middle Aged [MeSH]
lokal Progranulins/blood [MeSH]
lokal Phylogeny [MeSH]
lokal Epigenesis, Genetic [MeSH]
lokal DNA Methylation [MeSH]
lokal Protein Binding [MeSH]
lokal Genotype [MeSH]
lokal Alleles [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S2VsbGVyLCBNYXJpYQ==|https://frl.publisso.de/adhoc/uri/R2ViaGFyZHQsIENsYXVkaWE=|https://frl.publisso.de/adhoc/uri/SHV0aCwgU2FuZHJh|https://frl.publisso.de/adhoc/uri/U2NobGVpbml0eiwgRG9yaXQ=|https://frl.publisso.de/adhoc/uri/SGV5bmUsIEhlbnJpa2U=|https://frl.publisso.de/adhoc/uri/U2Nob2x6LCBNYXJrdXM=|https://frl.publisso.de/adhoc/uri/U3R1bXZvbGwsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/QsO2dHRjaGVyLCBZdm9ubmU=|https://frl.publisso.de/adhoc/uri/VMO2bmplcywgQW5rZQ==|https://orcid.org/0000-0002-0290-5423
1000 Hinweis
  • DeepGreen-ID: 5eb9a10479ec4b11a8be11674cc28017 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Dateien
1000 Objektart article
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1000 @id frl:6441525.rdf
1000 Erstellt am 2023-04-25T17:30:56.108+0200
1000 Erstellt von 322
1000 beschreibt frl:6441525
1000 Zuletzt bearbeitet 2023-10-19T10:13:04.844+0200
1000 Objekt bearb. Thu Oct 19 10:13:04 CEST 2023
1000 Vgl. frl:6441525
1000 Oai Id
  1. oai:frl.publisso.de:frl:6441525 |
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