Stress-mediated generation of deleterious ROS in healthy individuals - role of cytochrome c oxidase

  1. Ramzan, Rabia
  2. Vogt, Sebastian
  3. Kadenbach, Bernhard

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WeightNameValue
1000 Titel
  • Stress-mediated generation of deleterious ROS in healthy individuals - role of cytochrome c oxidase
1000 Autor/in
  1. Ramzan, Rabia |
  2. Vogt, Sebastian |
  3. Kadenbach, Bernhard |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-04-20
1000 Erschienen in
1000 Quellenangabe
  • 98(5):651-657
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00109-020-01905-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220878/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Psychosocial stress is known to cause an increased incidence of coronary heart disease. In addition, multiple other diseases like cancer and diabetes mellitus have been related to stress and are mainly based on excessive formation of reactive oxygen species (ROS) in mitochondria. The molecular interactions between stress and ROS, however, are still unknown. Here we describe the missing molecular link between stress and an increased cellular ROS, based on the regulation of cytochrome c oxidase (COX). In normal healthy cells, the 'allosteric ATP inhibition of COX' decreases the oxygen uptake of mitochondria at high ATP/ADP ratios and keeps the mitochondrial membrane potential (ΔΨ
1000 Sacherschließung
lokal Calcium/metabolism [MeSH]
lokal Reactive oxygen species (ROS)
lokal Stress, Psychological [MeSH]
lokal Mitochondria/metabolism [MeSH]
lokal Electron Transport Complex IV/metabolism [MeSH]
lokal Humans [MeSH]
lokal Reactive Oxygen Species/metabolism [MeSH]
lokal Prostaglandin-Endoperoxide Synthases/metabolism [MeSH]
lokal Adenosine Triphosphate/metabolism [MeSH]
lokal Animals [MeSH]
lokal Mitochondria/genetics [MeSH]
lokal Cytochrome c oxidase
lokal Membrane Potential, Mitochondrial [MeSH]
lokal Mitochondrial membrane potential
lokal Signal Transduction [MeSH]
lokal Review
lokal Stress, Physiological [MeSH]
lokal Biomarkers [MeSH]
lokal Stress
lokal Allosteric ATP inhibition
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/UmFtemFuLCBSYWJpYQ==|https://frl.publisso.de/adhoc/uri/Vm9ndCwgU2ViYXN0aWFu|https://frl.publisso.de/adhoc/uri/S2FkZW5iYWNoLCBCZXJuaGFyZA==
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1000 Erstellt am 2023-04-25T17:34:20.381+0200
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1000 Zuletzt bearbeitet Thu Oct 19 10:16:05 CEST 2023
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1000 Vgl. frl:6441539
1000 Oai Id
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