Intravascular adhesion and recruitment of neutrophils in response to CXCL1 depends on their TRPC6 channels

  1. Lindemann, Otto
  2. Rossaint, Jan
  3. Najder, Karolina
  4. Schimmelpfennig, Sandra
  5. Hofschröer, Verena
  6. Wälte, Mike
  7. Fels, Benedikt
  8. Oberleithner, Hans
  9. Zarbock, Alexander
  10. Schwab, Albrecht

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WeightNameValue
1000 Titel
  • Intravascular adhesion and recruitment of neutrophils in response to CXCL1 depends on their TRPC6 channels
1000 Autor/in
  1. Lindemann, Otto |
  2. Rossaint, Jan |
  3. Najder, Karolina |
  4. Schimmelpfennig, Sandra |
  5. Hofschröer, Verena |
  6. Wälte, Mike |
  7. Fels, Benedikt |
  8. Oberleithner, Hans |
  9. Zarbock, Alexander |
  10. Schwab, Albrecht |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-01-16
1000 Erschienen in
1000 Quellenangabe
  • 98(3):349-360
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00109-020-01872-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080674/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Here we report a novel role for TRPC6, a member of the transient receptor potential (TRPC) channel family, in the CXCL1-dependent recruitment of murine neutrophil granulocytes. Representing a central element of the innate immune system, neutrophils are recruited from the blood stream to a site of inflammation. The recruitment process follows a well-defined sequence of events including adhesion to the blood vessel walls, migration, and chemotaxis to reach the inflammatory focus. A common feature of the underlying signaling pathways is the utilization of Ca
1000 Sacherschließung
lokal CXCR2
lokal TRPC6 channel
lokal Calcium/metabolism [MeSH]
lokal Kidney/immunology [MeSH]
lokal Mice, Inbred C57BL [MeSH]
lokal Cell Adhesion [MeSH]
lokal Neutrophil recruitment
lokal Kidney/metabolism [MeSH]
lokal Reperfusion Injury/metabolism [MeSH]
lokal Chemokine CXCL1/immunology [MeSH]
lokal Neutrophils/physiology [MeSH]
lokal Animals [MeSH]
lokal TRPC6 Cation Channel/immunology [MeSH]
lokal Mice, Knockout [MeSH]
lokal Original Article
lokal Mice [MeSH]
lokal Kidney Diseases/immunology [MeSH]
lokal Chemotaxis [MeSH]
lokal Reperfusion Injury/immunology [MeSH]
lokal Kidney Diseases/metabolism [MeSH]
lokal CXCL1
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TGluZGVtYW5uLCBPdHRv|https://frl.publisso.de/adhoc/uri/Um9zc2FpbnQsIEphbg==|https://frl.publisso.de/adhoc/uri/TmFqZGVyLCBLYXJvbGluYQ==|https://frl.publisso.de/adhoc/uri/U2NoaW1tZWxwZmVubmlnLCBTYW5kcmE=|https://frl.publisso.de/adhoc/uri/SG9mc2NocsO2ZXIsIFZlcmVuYQ==|https://frl.publisso.de/adhoc/uri/V8OkbHRlLCBNaWtl|https://frl.publisso.de/adhoc/uri/RmVscywgQmVuZWRpa3Q=|https://frl.publisso.de/adhoc/uri/T2JlcmxlaXRobmVyLCBIYW5z|https://frl.publisso.de/adhoc/uri/WmFyYm9jaywgQWxleGFuZGVy|https://frl.publisso.de/adhoc/uri/U2Nod2FiLCBBbGJyZWNodA==
1000 Hinweis
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1000 Erstellt am 2023-04-25T17:34:44.292+0200
1000 Erstellt von 322
1000 beschreibt frl:6441541
1000 Zuletzt bearbeitet Thu Oct 19 10:16:28 CEST 2023
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