Sex Differences in Outcome After Thrombectomy for Acute Ischemic Stroke are Explained by Confounding Factors

  1. Deb-Chatterji, Milani ORCID logo
  2. Schlemm, Eckhard
  3. Flottmann, Fabian
  4. Meyer, Lukas
  5. Alegiani, Anna
  6. Brekenfeld, Caspar
  7. Fiehler, Jens
  8. Gerloff, Christian
  9. Thomalla, Götz
  10. Gerloff, C.
  11. Fiehler, J.
  12. Thomalla, G.
  13. Alegiani, A.
  14. Boeckh-Behrens,
  15. Wunderlich, Silke
  16. Ernemann, Ulrike
  17. Poli, Sven
  18. Siebert, Eberhard
  19. Nolte, Christian H.
  20. Zweynert, Sarah
  21. Bohner, Georg
  22. Ludolph, Alexander
  23. Henn, Karl-Heinz
  24. Pfeilschifter, Waltraud
  25. Keil, Fee
  26. Röther, Joachim
  27. Eckert, Bernd
  28. Berrouschot, Jörg
  29. Bormann, Albrecht
  30. Solymosi, László
  31. Petzold, Gabor
  32. Kraemer, Christoffer
  33. Dichgans, Martin
  34. Tiedt, Steffen
  35. Kellert, Lars
  36. Dorn, Franziska
  37. Petersen, Martina
  38. Stögbauer, Florian
  39. Braun, Michael
  40. Hamann, Gerhard F.
  41. Gröschel, Klaus
  42. Uphaus, Timo

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1000 Titel
  • Sex Differences in Outcome After Thrombectomy for Acute Ischemic Stroke are Explained by Confounding Factors
1000 Autor/in
  1. Deb-Chatterji, Milani |
  2. Schlemm, Eckhard |
  3. Flottmann, Fabian |
  4. Meyer, Lukas |
  5. Alegiani, Anna |
  6. Brekenfeld, Caspar |
  7. Fiehler, Jens |
  8. Gerloff, Christian |
  9. Thomalla, Götz |
  10. Gerloff, C. |
  11. Fiehler, J. |
  12. Thomalla, G. |
  13. Alegiani, A. |
  14. Boeckh-Behrens, |
  15. Wunderlich, Silke |
  16. Ernemann, Ulrike |
  17. Poli, Sven |
  18. Siebert, Eberhard |
  19. Nolte, Christian H. |
  20. Zweynert, Sarah |
  21. Bohner, Georg |
  22. Ludolph, Alexander |
  23. Henn, Karl-Heinz |
  24. Pfeilschifter, Waltraud |
  25. Keil, Fee |
  26. Röther, Joachim |
  27. Eckert, Bernd |
  28. Berrouschot, Jörg |
  29. Bormann, Albrecht |
  30. Solymosi, László |
  31. Petzold, Gabor |
  32. Kraemer, Christoffer |
  33. Dichgans, Martin |
  34. Tiedt, Steffen |
  35. Kellert, Lars |
  36. Dorn, Franziska |
  37. Petersen, Martina |
  38. Stögbauer, Florian |
  39. Braun, Michael |
  40. Hamann, Gerhard F. |
  41. Gröschel, Klaus |
  42. Uphaus, Timo |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-12-21
1000 Erschienen in
1000 Quellenangabe
  • 31(4):1101-1109
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00062-020-00983-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648700/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!The aim of this study was to analyze sex differences in outcome after thrombectomy for acute ischemic stroke in clinical practice in a large prospective multicenter registry.!##!Methods!#!Data of consecutive stroke patients treated with thrombectomy (June 2015-April 2018) derived from an industry-independent registry (German Stroke Registry-Endovascular Treatment) were prospectively analyzed. Multivariable binary logistic regression analyses were applied to determine whether sex is a predictor of functional independence outcome (defined as a modified Rankin scale [mRS] 0-2) 90 days after stroke.!##!Results!#!In total, 2316 patients were included in the analysis, 1170 (50.5%) were female and 1146 (49.5%) were male. Women were older (median age 78 vs. 72 years; p < 0.001) and more frequently had a prestroke functional impairment defined by mRS >1 (24.8% vs. 14.1%; p < 0.001). In unadjusted analyses, independent outcome at 90 days was less frequent in women (33.2%) than men (40.6%; p < 0.001). Likewise, mortality was higher in women than in men (30.7% vs. 26.4%; p = 0.024). In adjusted regression analyses, however, sex was not associated with outcome. Lower age, a lower baseline National Institutes of Health Stroke Scale score, a higher Alberta Stroke Program Early CT score, prestroke functional independence, successful reperfusion, and concomitant intravenous thrombolysis therapy predicted independent outcome.!##!Conclusion!#!Women showed a worse functional outcome after thrombectomy for acute ischemic stroke in clinical practice; however, after adjustment for crucial confounders sex was not a predictor of outcome. The difference in outcome thus appears to result from differences in confounding factors such as age and prestroke functional status.
1000 Sacherschließung
lokal Brain Ischemia/surgery [MeSH]
lokal Female [MeSH]
lokal Thrombectomy [MeSH]
lokal Aged [MeSH]
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal Treatment Outcome [MeSH]
lokal Angiography
lokal Retrospective Studies [MeSH]
lokal Gender difference
lokal Intervention
lokal Original Article
lokal Stroke/surgery [MeSH]
lokal Ischemic Stroke [MeSH]
lokal Ischemia
lokal Male [MeSH]
lokal Outcome predictors
lokal Sex Characteristics [MeSH]
lokal Endovascular Procedures [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-4282-3518|https://frl.publisso.de/adhoc/uri/U2NobGVtbSwgRWNraGFyZA==|https://frl.publisso.de/adhoc/uri/RmxvdHRtYW5uLCBGYWJpYW4=|https://frl.publisso.de/adhoc/uri/TWV5ZXIsIEx1a2Fz|https://frl.publisso.de/adhoc/uri/QWxlZ2lhbmksIEFubmE=|https://frl.publisso.de/adhoc/uri/QnJla2VuZmVsZCwgQ2FzcGFy|https://frl.publisso.de/adhoc/uri/RmllaGxlciwgSmVucw==|https://frl.publisso.de/adhoc/uri/R2VybG9mZiwgQ2hyaXN0aWFu|https://frl.publisso.de/adhoc/uri/VGhvbWFsbGEsIEfDtnR6|https://frl.publisso.de/adhoc/uri/R2VybG9mZiwgQy4=|https://frl.publisso.de/adhoc/uri/RmllaGxlciwgSi4=|https://frl.publisso.de/adhoc/uri/VGhvbWFsbGEsIEcu|https://frl.publisso.de/adhoc/uri/QWxlZ2lhbmksIEEu|https://frl.publisso.de/adhoc/uri/Qm9lY2toLUJlaHJlbnMsIA==|https://frl.publisso.de/adhoc/uri/V3VuZGVybGljaCwgU2lsa2U=|https://frl.publisso.de/adhoc/uri/RXJuZW1hbm4sIFVscmlrZQ==|https://frl.publisso.de/adhoc/uri/UG9saSwgU3Zlbg==|https://frl.publisso.de/adhoc/uri/U2llYmVydCwgRWJlcmhhcmQ=|https://frl.publisso.de/adhoc/uri/Tm9sdGUsIENocmlzdGlhbiBILg==|https://frl.publisso.de/adhoc/uri/WndleW5lcnQsIFNhcmFo|https://frl.publisso.de/adhoc/uri/Qm9obmVyLCBHZW9yZw==|https://frl.publisso.de/adhoc/uri/THVkb2xwaCwgQWxleGFuZGVy|https://frl.publisso.de/adhoc/uri/SGVubiwgS2FybC1IZWlueg==|https://frl.publisso.de/adhoc/uri/UGZlaWxzY2hpZnRlciwgV2FsdHJhdWQ=|https://frl.publisso.de/adhoc/uri/S2VpbCwgRmVl|https://frl.publisso.de/adhoc/uri/UsO2dGhlciwgSm9hY2hpbQ==|https://frl.publisso.de/adhoc/uri/RWNrZXJ0LCBCZXJuZA==|https://frl.publisso.de/adhoc/uri/QmVycm91c2Nob3QsIErDtnJn|https://frl.publisso.de/adhoc/uri/Qm9ybWFubiwgQWxicmVjaHQ=|https://frl.publisso.de/adhoc/uri/U29seW1vc2ksIEzDoXN6bMOz|https://frl.publisso.de/adhoc/uri/UGV0em9sZCwgR2Fib3I=|https://frl.publisso.de/adhoc/uri/S3JhZW1lciwgQ2hyaXN0b2ZmZXI=|https://frl.publisso.de/adhoc/uri/RGljaGdhbnMsIE1hcnRpbg==|https://frl.publisso.de/adhoc/uri/VGllZHQsIFN0ZWZmZW4=|https://frl.publisso.de/adhoc/uri/S2VsbGVydCwgTGFycw==|https://frl.publisso.de/adhoc/uri/RG9ybiwgRnJhbnppc2th|https://frl.publisso.de/adhoc/uri/UGV0ZXJzZW4sIE1hcnRpbmE=|https://frl.publisso.de/adhoc/uri/U3TDtmdiYXVlciwgRmxvcmlhbg==|https://frl.publisso.de/adhoc/uri/QnJhdW4sIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/SGFtYW5uLCBHZXJoYXJkIEYu|https://frl.publisso.de/adhoc/uri/R3LDtnNjaGVsLCBLbGF1cw==|https://frl.publisso.de/adhoc/uri/VXBoYXVzLCBUaW1v
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1000 Erstellt am 2023-04-26T11:47:10.111+0200
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