|
1000
|
Abstract/Summary
|
-
<jats:title>Abstract</jats:title><jats:p>The coupling of acetylated piperazinylamide spacered triterpenoic oleanolic acid and ursolic acid with<jats:italic>meta</jats:italic>or<jats:italic>para</jats:italic>substituted carboxylated malachite green analogs gave conjugates<jats:bold>10</jats:bold>,<jats:bold>11</jats:bold>,<jats:bold>15</jats:bold>, and<jats:bold>16</jats:bold>that were cytotoxic for several human tumor cell lines. Especially, an oleanolic acid-derived compound<jats:bold>10</jats:bold>was cytotoxic for MCF-7 human breast carcinoma cells (EC<jats:sub>50</jats:sub> = 0.7 μM). These derivatives represent first examples of triterpenoic acid derivatives holding a cationic scaffold derived from malachite green.</jats:p>
|
|
1000
|
Hinweis
|
-
DeepGreen-ID: dc56dda90fa3414697c1220ed2be9502 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
|
