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1000 Titel
  • 99mTc-labelled PSMA ligand for radio-guided surgery in nodal metastatic prostate cancer: proof of principle
1000 Autor/in
  1. Mix, Michael |
  2. Schultze-Seemann, Wolfgang |
  3. von Büren, Moritz |
  4. Sigle, August |
  5. Omrane, Mohamed A. |
  6. Grabbert, Markus T. |
  7. Werner, Martin |
  8. Gratzke, Christian |
  9. Meyer, Philipp T. |
  10. Jilg, Cordula A. |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-04
1000 Erschienen in
1000 Quellenangabe
  • 11(1):22
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s13550-021-00762-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933311/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!Intraoperative identification of prostate cancer (PCa) lymph node (LN) metastases (LNM) detected by preoperative PSMA PET/CT may be facilitated by PSMA radio-guided surgery (RGS) with use of a γ-probe. Earlier we demonstrated excellent performance of the !##!Methods!#!Six patients with PCa with the suspicion of LNM on preoperative PSMA-PET/CT underwent [!##!Results!#!Separation of the tissue samples from 73 subregions resulted in 498 single samples. After final histopathology 356 LN, 160 LNM und 11 non-nodal PCa samples were identified. Median SUL of tumor-free samples (0.26) and samples with cancer (3.5) was significantly different (p < 0.0001). ROC analysis revealed an area under the curve (AUC) of 0.917 (95% CI 0.89-0.95). Using a SUL cutoff of 1.1, sensitivity, specificity, positive predictive value, and negative predictive values were 76.6%, 94.4%, 89.4% and 86.9%.!##!Conclusion!#!Ex situ analysis of [
1000 Sacherschließung
lokal Radio-guided surgery
lokal PSMA Targeted Imaging and Therapy: Prostate and Other Cancers
lokal Original Research
lokal PSMA
lokal Salvage lymph node dissection
lokal Prostate cancer
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-9106-2519|https://frl.publisso.de/adhoc/uri/U2NodWx0emUtU2VlbWFubiwgV29sZmdhbmc=|https://frl.publisso.de/adhoc/uri/dm9uIELDvHJlbiwgTW9yaXR6|https://frl.publisso.de/adhoc/uri/U2lnbGUsIEF1Z3VzdA==|https://frl.publisso.de/adhoc/uri/T21yYW5lLCBNb2hhbWVkIEEu|https://frl.publisso.de/adhoc/uri/R3JhYmJlcnQsIE1hcmt1cyBULg==|https://frl.publisso.de/adhoc/uri/V2VybmVyLCBNYXJ0aW4=|https://frl.publisso.de/adhoc/uri/R3JhdHprZSwgQ2hyaXN0aWFu|https://frl.publisso.de/adhoc/uri/TWV5ZXIsIFBoaWxpcHAgVC4=|https://frl.publisso.de/adhoc/uri/SmlsZywgQ29yZHVsYSBBLg==
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1000 Erstellt am 2023-04-26T13:46:36.266+0200
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1000 Zuletzt bearbeitet Thu Oct 19 12:15:49 CEST 2023
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