Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease

  1. Mikolas, Pavol ORCID logo
  2. Bröckel, Kyra
  3. Vogelbacher, Christoph
  4. Müller, Dirk K.
  5. Marxen, Michael ORCID logo
  6. Berndt, Christina
  7. Sauer, Cathrin
  8. Jung, Stine
  9. Fröhner, Juliane ORCID logo
  10. Fallgatter, Andreas J.
  11. Ethofer, Thomas
  12. Rau, Anne
  13. Kircher, Tilo
  14. Falkenberg, Irina ORCID logo
  15. Lambert, Martin
  16. Kraft, Vivien ORCID logo
  17. Leopold, Karolina
  18. Bechdolf, Andreas
  19. Reif, Andreas ORCID logo
  20. Matura, Silke
  21. Stamm, Thomas
  22. Bermpohl, Felix
  23. Fiebig, Jana
  24. Juckel, Georg
  25. Flasbeck, Vera ORCID logo
  26. Correll, Christoph U.
  27. ritter, philipp ORCID logo
  28. Bauer, Michael ORCID logo
  29. Jansen, Andreas
  30. Pfennig, Andrea

Download
s41398-021-01598-y.pdf 827,32KB
WeightNameValue
1000 Titel
  • Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease
1000 Autor/in
  1. Mikolas, Pavol |
  2. Bröckel, Kyra |
  3. Vogelbacher, Christoph |
  4. Müller, Dirk K. |
  5. Marxen, Michael |
  6. Berndt, Christina |
  7. Sauer, Cathrin |
  8. Jung, Stine |
  9. Fröhner, Juliane |
  10. Fallgatter, Andreas J. |
  11. Ethofer, Thomas |
  12. Rau, Anne |
  13. Kircher, Tilo |
  14. Falkenberg, Irina |
  15. Lambert, Martin |
  16. Kraft, Vivien |
  17. Leopold, Karolina |
  18. Bechdolf, Andreas |
  19. Reif, Andreas |
  20. Matura, Silke |
  21. Stamm, Thomas |
  22. Bermpohl, Felix |
  23. Fiebig, Jana |
  24. Juckel, Georg |
  25. Flasbeck, Vera |
  26. Correll, Christoph U. |
  27. ritter, philipp |
  28. Bauer, Michael |
  29. Jansen, Andreas |
  30. Pfennig, Andrea |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-09-20
1000 Erschienen in
1000 Quellenangabe
  • 11(1):485
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-021-01598-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452775/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite a similar disease burden, the populations at risk of bipolar disorder have not been sufficiently characterized. Within the BipoLife consortium, we used magnetic resonance imaging (MRI) data from a multicenter study to assess structural gray matter alterations in N = 263 help-seeking individuals from seven study sites. We defined the risk using the EPIbipolar assessment tool as no-risk, low-risk, and high-risk and used a region-of-interest approach (ROI) based on the results of two large-scale multicenter studies of bipolar disorder by the ENIGMA working group. We detected significant differences in the thickness of the left pars opercularis (Cohen's d = 0.47, p = 0.024) between groups. The cortex was significantly thinner in high-risk individuals compared to those in the no-risk group (p = 0.011). We detected no differences in the hippocampal volume. Exploratory analyses revealed no significant differences in other cortical or subcortical regions. The thinner cortex in help-seeking individuals at risk of bipolar disorder is in line with previous findings in patients with the established disorder and corresponds to the region of the highest effect size in the ENIGMA study of cortical alterations. Structural alterations in prefrontal cortex might be a trait marker of bipolar risk. This is the largest structural MRI study of help-seeking individuals at increased risk of bipolar disorder.
1000 Sacherschließung
lokal Magnetic Resonance Imaging [MeSH]
lokal Article
lokal Brain/diagnostic imaging [MeSH]
lokal Prefrontal Cortex/diagnostic imaging [MeSH]
lokal Bipolar Disorder/diagnostic imaging [MeSH]
lokal Humans [MeSH]
lokal Bipolar disorder
lokal Risk Factors [MeSH]
lokal Diagnostic markers
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-3974-7115|https://frl.publisso.de/adhoc/uri/QnLDtmNrZWwsIEt5cmE=|https://frl.publisso.de/adhoc/uri/Vm9nZWxiYWNoZXIsIENocmlzdG9waA==|https://frl.publisso.de/adhoc/uri/TcO8bGxlciwgRGlyayBLLg==|https://orcid.org/0000-0001-8870-0041|https://frl.publisso.de/adhoc/uri/QmVybmR0LCBDaHJpc3RpbmE=|https://frl.publisso.de/adhoc/uri/U2F1ZXIsIENhdGhyaW4=|https://frl.publisso.de/adhoc/uri/SnVuZywgU3RpbmU=|https://orcid.org/0000-0002-8493-6396|https://frl.publisso.de/adhoc/uri/RmFsbGdhdHRlciwgQW5kcmVhcyBKLg==|https://frl.publisso.de/adhoc/uri/RXRob2ZlciwgVGhvbWFz|https://frl.publisso.de/adhoc/uri/UmF1LCBBbm5l|https://frl.publisso.de/adhoc/uri/S2lyY2hlciwgVGlsbw==|https://orcid.org/0000-0003-3699-0803|https://frl.publisso.de/adhoc/uri/TGFtYmVydCwgTWFydGlu|https://orcid.org/0000-0002-5815-1026|https://frl.publisso.de/adhoc/uri/TGVvcG9sZCwgS2Fyb2xpbmE=|https://frl.publisso.de/adhoc/uri/QmVjaGRvbGYsIEFuZHJlYXM=|https://orcid.org/0000-0002-0992-634X|https://frl.publisso.de/adhoc/uri/TWF0dXJhLCBTaWxrZQ==|https://frl.publisso.de/adhoc/uri/U3RhbW0sIFRob21hcw==|https://frl.publisso.de/adhoc/uri/QmVybXBvaGwsIEZlbGl4|https://frl.publisso.de/adhoc/uri/RmllYmlnLCBKYW5h|https://frl.publisso.de/adhoc/uri/SnVja2VsLCBHZW9yZw==|https://orcid.org/0000-0001-6405-4567|https://frl.publisso.de/adhoc/uri/Q29ycmVsbCwgQ2hyaXN0b3BoIFUu|https://orcid.org/0000-0003-4286-5830|https://orcid.org/0000-0002-2666-859X|https://frl.publisso.de/adhoc/uri/SmFuc2VuLCBBbmRyZWFz|https://frl.publisso.de/adhoc/uri/UGZlbm5pZywgQW5kcmVh
1000 Hinweis
  • DeepGreen-ID: 4506bec8a56c42d394029f394aed2b89 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6442498.rdf
1000 Erstellt am 2023-04-26T14:37:16.874+0200
1000 Erstellt von 322
1000 beschreibt frl:6442498
1000 Zuletzt bearbeitet 2023-10-19T12:47:19.341+0200
1000 Objekt bearb. Thu Oct 19 12:47:19 CEST 2023
1000 Vgl. frl:6442498
1000 Oai Id
  1. oai:frl.publisso.de:frl:6442498 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source