The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study

  1. Quattrone, Diego ORCID logo
  2. Reininghaus, Ulrich
  3. Richards, Alexander ORCID logo
  4. Tripoli, Giada
  5. Ferraro, Laura
  6. Quattrone, Andrea
  7. Marino, Paolo ORCID logo
  8. Rodríguez, Victoria ORCID logo
  9. Spinazzola, Edoardo
  10. Gayer-Anderson, Charlotte
  11. Jongsma, Hannah E.
  12. Jones, Peter ORCID logo
  13. La Cascia, Caterina
  14. La Barbera, Daniele
  15. Tarricone, Ilaria
  16. Bonora, Elena
  17. TOSATO, Sarah ORCID logo
  18. Lasalvia, Antonio
  19. Szöke, Andrei
  20. Arango, Celso
  21. Bernardo, Miquel ORCID logo
  22. Bobes, Julio ORCID logo
  23. Del-Ben, Cristina Marta ORCID logo
  24. Menezes, Paulo ORCID logo
  25. Llorca, Pierre michel ORCID logo
  26. Santos, Jose Luis
  27. Sanjuán, Julio
  28. Arrojo, Manuel
  29. Tortelli, Andrea
  30. Velthorst, Eva
  31. Berendsen, Steven
  32. de Haan, Lieuwe
  33. Rutten, Bart ORCID logo
  34. Lynskey, Michael T.
  35. Freeman, Tom P.
  36. Kirkbride, James ORCID logo
  37. Sham, Pak C.
  38. O'Donovan, Michael ORCID logo
  39. Cardno, Alastair G.
  40. Vassos, Evangelos ORCID logo
  41. van Os, Jim
  42. Morgan, Craig
  43. murray, robin ORCID logo
  44. Lewis, Cathryn ORCID logo
  45. Di Forti, Marta
  46. Hubbard, Kathryn
  47. Beards, Stephanie
  48. Stilo, Simona A.
  49. Parellada, Mara
  50. Fraguas, David
  51. Castro, Marta Rapado
  52. Andreu-Bernabeu, Álvaro
  53. López, Gonzalo
  54. Matteis, Mario
  55. González, Emiliano
  56. Durán-Cutilla, Manuel
  57. Díaz-Caneja, Covadonga M.
  58. Cuadrado, Pedro
  59. Rodríguez Solano, José Juan
  60. Carracedo, Angel
  61. Costas, Javier
  62. Sánchez, Emilio
  63. Amoretti, Silvia
  64. Lorente-Rovira, Esther
  65. Garcia-Portilla, Paz
  66. Jiménez-López, Estela
  67. van Dam, Daniella
  68. Termorshuizen, Fabian
  69. Franke, Nathalie
  70. van der Ven, Elsje
  71. Messchaart, Elles
  72. Leboyer, Marion
  73. Schürhoff, Franck
  74. Jamain, Stéphane
  75. Baudin, Grégoire
  76. Ferchiou, Aziz
  77. Pignon, Baptiste
  78. Richard, Jean-Romain
  79. Charpeaud, Thomas
  80. Tronche, Anne-Marie
  81. Frijda, Flora
  82. Marrazzo, Giovanna
  83. Sideli, Lucia
  84. Sartorio, Crocettarachele
  85. Seminerio, Fabio
  86. Loureiro, Camila Marcelino
  87. Shuhama, Rosana
  88. Ruggeri, Mirella
  89. Bonetto, Chiara
  90. Cristofalo, Doriana
  91. Berardi, Domenico
  92. Seri, Marco
  93. D’Andrea, Giuseppe

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1000 Titel
  • The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study
1000 Autor/in
  1. Quattrone, Diego |
  2. Reininghaus, Ulrich |
  3. Richards, Alexander |
  4. Tripoli, Giada |
  5. Ferraro, Laura |
  6. Quattrone, Andrea |
  7. Marino, Paolo |
  8. Rodríguez, Victoria |
  9. Spinazzola, Edoardo |
  10. Gayer-Anderson, Charlotte |
  11. Jongsma, Hannah E. |
  12. Jones, Peter |
  13. La Cascia, Caterina |
  14. La Barbera, Daniele |
  15. Tarricone, Ilaria |
  16. Bonora, Elena |
  17. TOSATO, Sarah |
  18. Lasalvia, Antonio |
  19. Szöke, Andrei |
  20. Arango, Celso |
  21. Bernardo, Miquel |
  22. Bobes, Julio |
  23. Del-Ben, Cristina Marta |
  24. Menezes, Paulo |
  25. Llorca, Pierre michel |
  26. Santos, Jose Luis |
  27. Sanjuán, Julio |
  28. Arrojo, Manuel |
  29. Tortelli, Andrea |
  30. Velthorst, Eva |
  31. Berendsen, Steven |
  32. de Haan, Lieuwe |
  33. Rutten, Bart |
  34. Lynskey, Michael T. |
  35. Freeman, Tom P. |
  36. Kirkbride, James |
  37. Sham, Pak C. |
  38. O'Donovan, Michael |
  39. Cardno, Alastair G. |
  40. Vassos, Evangelos |
  41. van Os, Jim |
  42. Morgan, Craig |
  43. murray, robin |
  44. Lewis, Cathryn |
  45. Di Forti, Marta |
  46. Hubbard, Kathryn |
  47. Beards, Stephanie |
  48. Stilo, Simona A. |
  49. Parellada, Mara |
  50. Fraguas, David |
  51. Castro, Marta Rapado |
  52. Andreu-Bernabeu, Álvaro |
  53. López, Gonzalo |
  54. Matteis, Mario |
  55. González, Emiliano |
  56. Durán-Cutilla, Manuel |
  57. Díaz-Caneja, Covadonga M. |
  58. Cuadrado, Pedro |
  59. Rodríguez Solano, José Juan |
  60. Carracedo, Angel |
  61. Costas, Javier |
  62. Sánchez, Emilio |
  63. Amoretti, Silvia |
  64. Lorente-Rovira, Esther |
  65. Garcia-Portilla, Paz |
  66. Jiménez-López, Estela |
  67. van Dam, Daniella |
  68. Termorshuizen, Fabian |
  69. Franke, Nathalie |
  70. van der Ven, Elsje |
  71. Messchaart, Elles |
  72. Leboyer, Marion |
  73. Schürhoff, Franck |
  74. Jamain, Stéphane |
  75. Baudin, Grégoire |
  76. Ferchiou, Aziz |
  77. Pignon, Baptiste |
  78. Richard, Jean-Romain |
  79. Charpeaud, Thomas |
  80. Tronche, Anne-Marie |
  81. Frijda, Flora |
  82. Marrazzo, Giovanna |
  83. Sideli, Lucia |
  84. Sartorio, Crocettarachele |
  85. Seminerio, Fabio |
  86. Loureiro, Camila Marcelino |
  87. Shuhama, Rosana |
  88. Ruggeri, Mirella |
  89. Bonetto, Chiara |
  90. Cristofalo, Doriana |
  91. Berardi, Domenico |
  92. Seri, Marco |
  93. D’Andrea, Giuseppe |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-08-10
1000 Erschienen in
1000 Quellenangabe
  • 11(1):423
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-021-01526-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355107/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03-0.33) and positive (B = 0.19; 95%CI 0.03-0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11-0.52) and in controls (B = 0.26; 95%CI 0.06-0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders.
1000 Sacherschließung
lokal Linear Models [MeSH]
lokal Schizophrenia/genetics [MeSH]
lokal Article
lokal Psychotic Disorders/diagnosis [MeSH]
lokal Cannabis [MeSH]
lokal Humans [MeSH]
lokal Psychotic Disorders/genetics [MeSH]
lokal Predictive markers
lokal Risk Factors [MeSH]
lokal Schizophrenia
lokal Clinical genetics
1000 Liste der Beteiligten
  1. 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