A genome-wide association study of the longitudinal course of executive functions

  1. Wendel, Bernadette ORCID logo
  2. Papiol, Sergi ORCID logo
  3. Andlauer, Till ORCID logo
  4. Zimmermann, Jörg
  5. Wiltfang, Jens ORCID logo
  6. Spitzer, Carsten
  7. Senner, Fanny
  8. Schulte, Eva C.
  9. Schmauß, Max
  10. Schaupp, Sabrina K.
  11. Repple, Jonathan
  12. Reininghaus, Eva
  13. Reimer, Jens
  14. Reich-Erkelenz, Daniela
  15. Opel, Nils
  16. Nenadić, Igor
  17. Meinert, Susanne
  18. Konrad, Carsten
  19. Klöhn-Saghatolislam, Farahnaz
  20. Kircher, Tilo
  21. Kalman, Janos L.
  22. Juckel, Georg
  23. Jansen, Andreas
  24. Jäger, Markus
  25. Heilbronner, Maria
  26. von Hagen, Martin
  27. Gade, Katrin
  28. Figge, Christian
  29. Fallgatter, Andreas J.
  30. Dietrich, Detlef E.
  31. Dannlowski, Udo
  32. Comes, Ashley ORCID logo
  33. Budde, Monika ORCID logo
  34. Baune, Bernhard T.
  35. Arolt, Volker
  36. Anghelescu, Ion-George
  37. Anderson-Schmidt, Heike
  38. Adorjan, Kristina
  39. Falkai, Peter
  40. Schulze, Thomas G.
  41. Bickeböller, Heike ORCID logo
  42. Heilbronner, Urs ORCID logo

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1000 Titel
  • A genome-wide association study of the longitudinal course of executive functions
1000 Autor/in
  1. Wendel, Bernadette |
  2. Papiol, Sergi |
  3. Andlauer, Till |
  4. Zimmermann, Jörg |
  5. Wiltfang, Jens |
  6. Spitzer, Carsten |
  7. Senner, Fanny |
  8. Schulte, Eva C. |
  9. Schmauß, Max |
  10. Schaupp, Sabrina K. |
  11. Repple, Jonathan |
  12. Reininghaus, Eva |
  13. Reimer, Jens |
  14. Reich-Erkelenz, Daniela |
  15. Opel, Nils |
  16. Nenadić, Igor |
  17. Meinert, Susanne |
  18. Konrad, Carsten |
  19. Klöhn-Saghatolislam, Farahnaz |
  20. Kircher, Tilo |
  21. Kalman, Janos L. |
  22. Juckel, Georg |
  23. Jansen, Andreas |
  24. Jäger, Markus |
  25. Heilbronner, Maria |
  26. von Hagen, Martin |
  27. Gade, Katrin |
  28. Figge, Christian |
  29. Fallgatter, Andreas J. |
  30. Dietrich, Detlef E. |
  31. Dannlowski, Udo |
  32. Comes, Ashley |
  33. Budde, Monika |
  34. Baune, Bernhard T. |
  35. Arolt, Volker |
  36. Anghelescu, Ion-George |
  37. Anderson-Schmidt, Heike |
  38. Adorjan, Kristina |
  39. Falkai, Peter |
  40. Schulze, Thomas G. |
  41. Bickeböller, Heike |
  42. Heilbronner, Urs |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-10
1000 Erschienen in
1000 Quellenangabe
  • 11(1):386
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-021-01510-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272719/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Executive functions are metacognitive capabilities that control and coordinate mental processes. In the transdiagnostic PsyCourse Study, comprising patients of the affective-to-psychotic spectrum and controls, we investigated the genetic basis of the time course of two core executive subfunctions: set-shifting (Trail Making Test, part B (TMT-B)) and updating (Verbal Digit Span backwards) in 1338 genotyped individuals. Time course was assessed with four measurement points, each 6 months apart. Compared to the initial assessment, executive performance improved across diagnostic groups. We performed a genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with performance change over time by testing for SNP-by-time interactions using linear mixed models. We identified nine genome-wide significant SNPs for TMT-B in strong linkage disequilibrium with each other on chromosome 5. These were associated with decreased performance on the continuous TMT-B score across time. Variant rs150547358 had the lowest P value = 7.2x10(-10) with effect estimate beta=1.16 (95% c.i.: 1.11, 1.22). Implementing data of the FOR2107 consortium (1795 individuals), we replicated these findings for the SNP rs150547358 (P value=0.015), analyzing the difference of the two available measurement points two years apart. In the replication study, rs150547358 exhibited a similar effect estimate beta=0.85 (95% c.i.: 0.74, 0.97). Our study demonstrates that longitudinally measured phenotypes have the potential to unmask novel associations, adding time as a dimension to the effects of genomics.
1000 Sacherschließung
lokal Genomics
lokal Article
lokal Executive Function [MeSH]
lokal Linkage Disequilibrium [MeSH]
lokal Polymorphism, Single Nucleotide [MeSH]
lokal Humans [MeSH]
lokal Genotype [MeSH]
lokal Psychology
lokal Genome-Wide Association Study [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-5628-9398|https://orcid.org/0000-0001-9366-8728|https://orcid.org/0000-0002-2917-5889|https://frl.publisso.de/adhoc/uri/WmltbWVybWFubiwgSsO2cmc=|https://orcid.org/0000-0003-1492-5330|https://frl.publisso.de/adhoc/uri/U3BpdHplciwgQ2Fyc3Rlbg==|https://frl.publisso.de/adhoc/uri/U2VubmVyLCBGYW5ueQ==|https://frl.publisso.de/adhoc/uri/U2NodWx0ZSwgRXZhIEMu|https://frl.publisso.de/adhoc/uri/U2NobWF1w58sIE1heA==|https://frl.publisso.de/adhoc/uri/U2NoYXVwcCwgU2FicmluYSBLLg==|https://frl.publisso.de/adhoc/uri/UmVwcGxlLCBKb25hdGhhbg==|https://frl.publisso.de/adhoc/uri/UmVpbmluZ2hhdXMsIEV2YQ==|https://frl.publisso.de/adhoc/uri/UmVpbWVyLCBKZW5z|https://frl.publisso.de/adhoc/uri/UmVpY2gtRXJrZWxlbnosIERhbmllbGE=|https://frl.publisso.de/adhoc/uri/T3BlbCwgTmlscw==|https://frl.publisso.de/adhoc/uri/TmVuYWRpxIcsIElnb3I=|https://frl.publisso.de/adhoc/uri/TWVpbmVydCwgU3VzYW5uZQ==|https://frl.publisso.de/adhoc/uri/S29ucmFkLCBDYXJzdGVu|https://frl.publisso.de/adhoc/uri/S2zDtmhuLVNhZ2hhdG9saXNsYW0sIEZhcmFobmF6|https://frl.publisso.de/adhoc/uri/S2lyY2hlciwgVGlsbw==|https://frl.publisso.de/adhoc/uri/S2FsbWFuLCBKYW5vcyBMLg==|https://frl.publisso.de/adhoc/uri/SnVja2VsLCBHZW9yZw==|https://frl.publisso.de/adhoc/uri/SmFuc2VuLCBBbmRyZWFz|https://frl.publisso.de/adhoc/uri/SsOkZ2VyLCBNYXJrdXM=|https://frl.publisso.de/adhoc/uri/SGVpbGJyb25uZXIsIE1hcmlh|https://frl.publisso.de/adhoc/uri/dm9uIEhhZ2VuLCBNYXJ0aW4=|https://frl.publisso.de/adhoc/uri/R2FkZSwgS2F0cmlu|https://frl.publisso.de/adhoc/uri/RmlnZ2UsIENocmlzdGlhbg==|https://frl.publisso.de/adhoc/uri/RmFsbGdhdHRlciwgQW5kcmVhcyBKLg==|https://frl.publisso.de/adhoc/uri/RGlldHJpY2gsIERldGxlZiBFLg==|https://frl.publisso.de/adhoc/uri/RGFubmxvd3NraSwgVWRv|https://orcid.org/0000-0001-6745-9834|https://orcid.org/0000-0001-7301-9157|https://frl.publisso.de/adhoc/uri/QmF1bmUsIEJlcm5oYXJkIFQu|https://frl.publisso.de/adhoc/uri/QXJvbHQsIFZvbGtlcg==|https://frl.publisso.de/adhoc/uri/QW5naGVsZXNjdSwgSW9uLUdlb3JnZQ==|https://frl.publisso.de/adhoc/uri/QW5kZXJzb24tU2NobWlkdCwgSGVpa2U=|https://frl.publisso.de/adhoc/uri/QWRvcmphbiwgS3Jpc3RpbmE=|https://frl.publisso.de/adhoc/uri/RmFsa2FpLCBQZXRlcg==|https://frl.publisso.de/adhoc/uri/U2NodWx6ZSwgVGhvbWFzIEcu|https://orcid.org/0000-0002-3361-5488|https://orcid.org/0000-0001-7135-762X
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  • DeepGreen-ID: a18237998fa6438ca02b85997ccdd582 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-04-26T14:41:29.654+0200
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1000 Zuletzt bearbeitet 2023-10-19T12:49:51.724+0200
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