Excitatory–inhibitory balance within EEG microstates and resting-state fMRI networks: assessed via simultaneous trimodal PET–MR–EEG imaging

  1. Rajkumar, Ravichandran ORCID logo
  2. Régio Brambilla, Cláudia ORCID logo
  3. Veselinovic, Tanja ORCID logo
  4. Bierbrier, Joshua
  5. Wyss, Christine ORCID logo
  6. Ramkiran, Shukti ORCID logo
  7. Orth, Linda ORCID logo
  8. Lang, Markus
  9. Rota Kops, Elena
  10. Mauler, Jörg ORCID logo
  11. Scheins, Jürgen
  12. Ermert, Johannes ORCID logo
  13. Neumaier, Bernd ORCID logo
  14. Herzog, Hans
  15. Langen, Karl-Josef
  16. Binkofski, Ferdinand Christoph
  17. Lerche, Christoph ORCID logo
  18. Shah, N. Jon
  19. Neuner, Irene ORCID logo

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1000 Titel
  • Excitatory–inhibitory balance within EEG microstates and resting-state fMRI networks: assessed via simultaneous trimodal PET–MR–EEG imaging
1000 Autor/in
  1. Rajkumar, Ravichandran |
  2. Régio Brambilla, Cláudia |
  3. Veselinovic, Tanja |
  4. Bierbrier, Joshua |
  5. Wyss, Christine |
  6. Ramkiran, Shukti |
  7. Orth, Linda |
  8. Lang, Markus |
  9. Rota Kops, Elena |
  10. Mauler, Jörg |
  11. Scheins, Jürgen |
  12. Ermert, Johannes |
  13. Neumaier, Bernd |
  14. Herzog, Hans |
  15. Langen, Karl-Josef |
  16. Binkofski, Ferdinand Christoph |
  17. Lerche, Christoph |
  18. Shah, N. Jon |
  19. Neuner, Irene |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-18
1000 Erschienen in
1000 Quellenangabe
  • 11(1):60
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-020-01160-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813876/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The symbiosis of neuronal activities and glucose energy metabolism is reflected in the generation of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) signals. However, their association with the balance between neuronal excitation and inhibition (E/I-B), which is closely related to the activities of glutamate and gamma -aminobutyric acid (GABA) and the receptor availability (RA) of GABA(A) and mGluR5, remains unexplored. This research investigates these associations during the resting state (RS) condition using simultaneously recorded PET/MR/EEG (trimodal) data. The trimodal data were acquired from three studies using different radio-tracers such as, [C-11]ABP688 (ABP) (N=9), [C-11]Flumazenil (FMZ) (N=10) and 2-[F-18]fluoro-2-deoxy-d-glucose (FDG) (N=10) targeted to study the mGluR5, GABA(A) receptors and glucose metabolism respectively. Glucose metabolism and neuroreceptor binding availability (non-displaceable binding potential (BPND)) of GABA(A) and mGluR5 were found to be significantly higher and closely linked within core resting-state networks (RSNs). The neuronal generators of EEG microstates and the fMRI measures were most tightly associated with the BPND of GABA(A) relative to mGluR5 BPND and the glucose metabolism, emphasizing a predominance of inhibitory processes within in the core RSNs at rest. Changes in the neuroreceptors leading to an altered coupling with glucose metabolism may render the RSNs vulnerable to psychiatric conditions. The paradigm employed here will likely help identify the precise neurobiological mechanisms behind these alterations in fMRI functional connectivity and EEG oscillations, potentially benefitting individualized healthcare treatment measures.
1000 Sacherschließung
lokal Magnetic Resonance Imaging [MeSH]
lokal Article
lokal Brain/diagnostic imaging [MeSH]
lokal Neuroscience
lokal Positron-Emission Tomography [MeSH]
lokal Brain Mapping [MeSH]
lokal Molecular neuroscience
lokal Electroencephalography [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-5875-5316|https://orcid.org/0000-0002-3735-8511|https://orcid.org/0000-0001-7906-6966|https://frl.publisso.de/adhoc/uri/QmllcmJyaWVyLCBKb3NodWE=|https://orcid.org/0000-0003-2088-9794|https://orcid.org/0000-0001-8253-1873|https://orcid.org/0000-0003-0733-9624|https://frl.publisso.de/adhoc/uri/TGFuZywgTWFya3Vz|https://frl.publisso.de/adhoc/uri/Um90YSBLb3BzLCBFbGVuYQ==|https://orcid.org/0000-0003-4937-0355|https://frl.publisso.de/adhoc/uri/U2NoZWlucywgSsO8cmdlbg==|https://orcid.org/0000-0002-2561-7766|https://orcid.org/0000-0001-5425-3116|https://frl.publisso.de/adhoc/uri/SGVyem9nLCBIYW5z|https://frl.publisso.de/adhoc/uri/TGFuZ2VuLCBLYXJsLUpvc2Vm|https://frl.publisso.de/adhoc/uri/Qmlua29mc2tpLCBGZXJkaW5hbmQgQ2hyaXN0b3Bo|https://orcid.org/0000-0003-2749-2108|https://frl.publisso.de/adhoc/uri/U2hhaCwgTi4gSm9u|https://orcid.org/0000-0002-5164-8873
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1000 Erstellt am 2023-04-26T14:50:42.424+0200
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