The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency

  1. Arora, Prerna
  2. Rocha, Cheila
  3. Kempf, Amy
  4. Nehlmeier, Inga ORCID logo
  5. Graichen, Luise
  6. Winkler, Martin S.
  7. Lier, Martin
  8. Schulz, Sebastian ORCID logo
  9. Jäck, Hans-Martin
  10. Cossmann, Anne
  11. Stankov, Metodi V.
  12. Behrens, Georg ORCID logo
  13. Pöhlmann, Stefan ORCID logo
  14. Hoffmann, Markus ORCID logo

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WeightNameValue
1000 Titel
  • The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency
1000 Autor/in
  1. Arora, Prerna |
  2. Rocha, Cheila |
  3. Kempf, Amy |
  4. Nehlmeier, Inga |
  5. Graichen, Luise |
  6. Winkler, Martin S. |
  7. Lier, Martin |
  8. Schulz, Sebastian |
  9. Jäck, Hans-Martin |
  10. Cossmann, Anne |
  11. Stankov, Metodi V. |
  12. Behrens, Georg |
  13. Pöhlmann, Stefan |
  14. Hoffmann, Markus |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-10-25
1000 Erschienen in
1000 Quellenangabe
  • 18(12):2673-2675
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41423-021-00779-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543421/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Signaling via interleukin-2 receptor (IL-2R) is a requisite for regulatory T (Treg) cell identity and function. However, it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis, lineage stability and function in both resting and inflammatory conditions. Here, we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25, the α-chain of IL-2R, which resulted in diminished receptor expression and reduced IL-2R signaling. Under noninflammatory conditions, Cd25
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Antibodies, Viral/immunology [MeSH]
lokal Mutation [MeSH]
lokal Humans [MeSH]
lokal Cell Line [MeSH]
lokal SARS-CoV-2/genetics [MeSH]
lokal Infection
lokal COVID-19 Vaccines/immunology [MeSH]
lokal Spike Glycoprotein, Coronavirus/genetics [MeSH]
lokal Antibodies, Neutralizing/immunology [MeSH]
lokal SARS-CoV-2/immunology [MeSH]
lokal Spike Glycoprotein, Coronavirus/immunology [MeSH]
lokal Correspondence
lokal Virus Internalization [MeSH]
lokal Antibodies
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/QXJvcmEsIFByZXJuYQ==|https://frl.publisso.de/adhoc/uri/Um9jaGEsIENoZWlsYQ==|https://frl.publisso.de/adhoc/uri/S2VtcGYsIEFteQ==|https://orcid.org/0000-0002-8752-7491|https://frl.publisso.de/adhoc/uri/R3JhaWNoZW4sIEx1aXNl|https://frl.publisso.de/adhoc/uri/V2lua2xlciwgTWFydGluIFMu|https://frl.publisso.de/adhoc/uri/TGllciwgTWFydGlu|https://orcid.org/0000-0001-6554-3346|https://frl.publisso.de/adhoc/uri/SsOkY2ssIEhhbnMtTWFydGlu|https://frl.publisso.de/adhoc/uri/Q29zc21hbm4sIEFubmU=|https://frl.publisso.de/adhoc/uri/U3RhbmtvdiwgTWV0b2RpIFYu|https://orcid.org/0000-0003-3111-621X|https://orcid.org/0000-0001-6086-9136|https://orcid.org/0000-0003-4603-7696
1000 Hinweis
  • DeepGreen-ID: f8a604d7d2c54a119915cb28ef771374 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Dateien
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1000 @id frl:6442824.rdf
1000 Erstellt am 2023-04-26T15:51:29.152+0200
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1000 Zuletzt bearbeitet 2023-10-13T13:32:46.243+0200
1000 Objekt bearb. Fri Oct 13 13:32:46 CEST 2023
1000 Vgl. frl:6442824
1000 Oai Id
  1. oai:frl.publisso.de:frl:6442824 |
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