The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes

  1. Wiechers, Carolin
  2. Zou, Mangge
  3. Gálvez, Eric J.C. ORCID logo
  4. Beckstette, Michael
  5. Ebel, Maria
  6. Strowig, Till ORCID logo
  7. Huehn, Jochen ORCID logo
  8. Pezoldt, Joern ORCID logo

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WeightNameValue
1000 Titel
  • The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes
1000 Autor/in
  1. Wiechers, Carolin |
  2. Zou, Mangge |
  3. Gálvez, Eric J.C. |
  4. Beckstette, Michael |
  5. Ebel, Maria |
  6. Strowig, Till |
  7. Huehn, Jochen |
  8. Pezoldt, Joern |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-24
1000 Erschienen in
1000 Quellenangabe
  • 18(5):1211-1221
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41423-021-00647-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093251/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Signaling via interleukin-2 receptor (IL-2R) is a requisite for regulatory T (Treg) cell identity and function. However, it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis, lineage stability and function in both resting and inflammatory conditions. Here, we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25, the α-chain of IL-2R, which resulted in diminished receptor expression and reduced IL-2R signaling. Under noninflammatory conditions, Cd25
1000 Sacherschließung
lokal Dysbiosis/microbiology [MeSH]
lokal Female [MeSH]
lokal Mice, Inbred BALB C [MeSH]
lokal Mice, Inbred C57BL [MeSH]
lokal Peripheral regulatory T cells
lokal Transcriptome/genetics [MeSH]
lokal Tolerance
lokal T-Lymphocytes, Regulatory/immunology [MeSH]
lokal Gastrointestinal Microbiome/immunology [MeSH]
lokal T-Lymphocytes, Regulatory/drug effects [MeSH]
lokal Animals [MeSH]
lokal Fatty Acids, Volatile/pharmacology [MeSH]
lokal Microbiota
lokal Gastrointestinal Microbiome/drug effects [MeSH]
lokal Dysbiosis/pathology [MeSH]
lokal Lymph Nodes/immunology [MeSH]
lokal Article
lokal Mesentery/immunology [MeSH]
lokal Lymph Nodes/drug effects [MeSH]
lokal Gene Expression Profiling [MeSH]
lokal Chromatin/metabolism [MeSH]
lokal Transcription, Genetic/drug effects [MeSH]
lokal Epigenesis, Genetic/drug effects [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/V2llY2hlcnMsIENhcm9saW4=|https://frl.publisso.de/adhoc/uri/Wm91LCBNYW5nZ2U=|https://orcid.org/0000-0001-7459-3871|https://frl.publisso.de/adhoc/uri/QmVja3N0ZXR0ZSwgTWljaGFlbA==|https://frl.publisso.de/adhoc/uri/RWJlbCwgTWFyaWE=|https://orcid.org/0000-0003-0185-1459|https://orcid.org/0000-0001-8071-1379|https://orcid.org/0000-0001-7143-5691
1000 Hinweis
  • DeepGreen-ID: 8367b8dc121d4848899817cdee22ef23 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 @id frl:6442836.rdf
1000 Erstellt am 2023-04-26T15:53:58.366+0200
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1000 Zuletzt bearbeitet 2023-10-19T13:30:10.383+0200
1000 Objekt bearb. Thu Oct 19 13:30:10 CEST 2023
1000 Vgl. frl:6442836
1000 Oai Id
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