TCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential

  1. Poorebrahim, Mansour ORCID logo
  2. Mohammadkhani, Niloufar
  3. Mahmoudi, Reza
  4. Gholizadeh, Monireh
  5. Fakhr, Elham
  6. Cid-Arregui, Angel ORCID logo

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WeightNameValue
1000 Titel
  • TCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential
1000 Autor/in
  1. Poorebrahim, Mansour |
  2. Mohammadkhani, Niloufar |
  3. Mahmoudi, Reza |
  4. Gholizadeh, Monireh |
  5. Fakhr, Elham |
  6. Cid-Arregui, Angel |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-02
1000 Erschienen in
1000 Quellenangabe
  • 28(6):581-589
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41417-021-00307-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203496/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Neoepitopes or neoantigens are a spectrum of unique mutations presented in a particular patient's tumor. Neoepitope-based adoptive therapies have the potential of tumor eradication without undue damaging effect on normal tissues. In this context, methods based on the T cell receptor (TCR) engineering or chimeric antigen receptors (CARs) have shown great promise. This review focuses on the TCR-like CARs and TCR-CARs directed against tumor-derived epitopes, with a concerted view on neoepitopes. We also address the current limitations of the field to know how to harness the full benefits of this approach and thereby design a sustained and specific antitumor therapy.
1000 Sacherschließung
lokal Immunotherapy, Adoptive [MeSH]
lokal T-Lymphocytes/immunology [MeSH]
lokal Humans [MeSH]
lokal Neoplasms/immunology [MeSH]
lokal Review Article
lokal Neoplasms/genetics [MeSH]
lokal Receptors, Antigen, T-Cell/immunology [MeSH]
lokal Receptors, Chimeric Antigen/genetics [MeSH]
lokal Antigens, Neoplasm/immunology [MeSH]
lokal Neoplasms/therapy [MeSH]
lokal Receptors, Antigen, T-Cell/genetics [MeSH]
lokal Cancer immunotherapy
lokal Receptors, Antigen, T-Cell/therapeutic use [MeSH]
lokal Translational immunology
lokal Antigens, Neoplasm/therapeutic use [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-0956-3507|https://frl.publisso.de/adhoc/uri/TW9oYW1tYWRraGFuaSwgTmlsb3VmYXI=|https://frl.publisso.de/adhoc/uri/TWFobW91ZGksIFJlemE=|https://frl.publisso.de/adhoc/uri/R2hvbGl6YWRlaCwgTW9uaXJlaA==|https://frl.publisso.de/adhoc/uri/RmFraHIsIEVsaGFt|https://orcid.org/0000-0003-1433-2922
1000 Hinweis
  • DeepGreen-ID: 45cb3637395f4ed88f8c5729a4e8b9f0 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 @id frl:6442856.rdf
1000 Erstellt am 2023-04-26T15:58:22.095+0200
1000 Erstellt von 322
1000 beschreibt frl:6442856
1000 Zuletzt bearbeitet 2023-10-19T13:31:43.824+0200
1000 Objekt bearb. Thu Oct 19 13:31:43 CEST 2023
1000 Vgl. frl:6442856
1000 Oai Id
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