Exploiting lipotoxicity for the treatment of liver cancer

  1. Rudalska, Ramona ORCID logo
  2. Zender, Lars
  3. Dauch, Daniel ORCID logo

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WeightNameValue
1000 Titel
  • Exploiting lipotoxicity for the treatment of liver cancer
1000 Autor/in
  1. Rudalska, Ramona |
  2. Zender, Lars |
  3. Dauch, Daniel |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-23
1000 Erschienen in
1000 Quellenangabe
  • 125(11):1459-1461
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41416-021-01479-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608911/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Metabolic alterations occur frequently in solid tumours, but metabolic cancer therapies are limited by the complexity and plasticity of metabolic networks. We could recently show that activation of the liver X receptor alpha (LXRα) and inhibition of a Raf-1-SCD1 protein complex induces an intracellular accumulation of saturated free fatty acids leading to lethal lipotoxicity in tumour cells and allows for an efficient treatment of liver carcinomas.
1000 Sacherschließung
lokal Liver X Receptors/therapeutic use [MeSH]
lokal Humans [MeSH]
lokal Liver Neoplasms/therapy [MeSH]
lokal Hepatocellular carcinoma
lokal Targeted therapies
lokal Comment
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-1742-0912|https://frl.publisso.de/adhoc/uri/WmVuZGVyLCBMYXJz|https://orcid.org/0000-0002-9805-5784
1000 Hinweis
  • DeepGreen-ID: 23d686b58565457ebea3027beea0af2f ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
  1. Exploiting lipotoxicity for the treatment of liver cancer
    Exploiting lipotoxicity for the treatment of liver cancer
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1000 @id frl:6442872.rdf
1000 Erstellt am 2023-04-26T16:02:42.147+0200
1000 Erstellt von 322
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1000 Zuletzt bearbeitet 2023-10-19T13:33:36.524+0200
1000 Objekt bearb. Thu Oct 19 13:33:36 CEST 2023
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