Active surveillance inclusion criteria under scrutiny in magnetic resonance imaging-guided prostate biopsy: a multicenter cohort study

  1. Siegel, Fabian ORCID logo
  2. Borkowetz, Angelika
  3. Drerup, Martin
  4. Lieb, Verena
  5. Bruendl, Johannes
  6. Höfner, Thomas
  7. Cash, Hannes
  8. von Hardenberg, Jost
  9. Beyer, Burkhard
  10. Bründl, Johannes
  11. Cash, Johannes
  12. Herrmann, Jonas
  13. Radtke, Jan Philipp
  14. Hoffmann, Manuela A.
  15. Leitsmann, Conrad
  16. Kornienko, Kira
  17. Worst, Thomas
  18. Borgmann, Hendrik
  19. Linxweiler, Johannes
  20. Klümper, Niklas
  21. Wenzel, Mike
  22. Welte, Maria Noemi
  23. Westhoff, Niklas
  24. Würnschimmel, Christoph
  25. Sigle, August
  26. Mahjoub, Samy
  27. Ortner, Gernot
  28. Kwe, Jeremy
  29. Langenberger, Sven-Thorben

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1000 Titel
  • Active surveillance inclusion criteria under scrutiny in magnetic resonance imaging-guided prostate biopsy: a multicenter cohort study
1000 Autor/in
  1. Siegel, Fabian |
  2. Borkowetz, Angelika |
  3. Drerup, Martin |
  4. Lieb, Verena |
  5. Bruendl, Johannes |
  6. Höfner, Thomas |
  7. Cash, Hannes |
  8. von Hardenberg, Jost |
  9. Beyer, Burkhard |
  10. Bründl, Johannes |
  11. Cash, Johannes |
  12. Herrmann, Jonas |
  13. Radtke, Jan Philipp |
  14. Hoffmann, Manuela A. |
  15. Leitsmann, Conrad |
  16. Kornienko, Kira |
  17. Worst, Thomas |
  18. Borgmann, Hendrik |
  19. Linxweiler, Johannes |
  20. Klümper, Niklas |
  21. Wenzel, Mike |
  22. Welte, Maria Noemi |
  23. Westhoff, Niklas |
  24. Würnschimmel, Christoph |
  25. Sigle, August |
  26. Mahjoub, Samy |
  27. Ortner, Gernot |
  28. Kwe, Jeremy |
  29. Langenberger, Sven-Thorben |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-17
1000 Erschienen in
1000 Quellenangabe
  • 25(1):109-116
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41391-021-00478-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018419/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Although multiparametric magnetic resonance imaging (mpMRI) is recommended for primary risk stratification and follow-up in Active Surveillance (AS), it is not part of common AS inclusion criteria. The objective was to compare AS eligibility by systematic biopsy (SB) and combined MRI-targeted (MRI-TB) and SB within real-world data using current AS guidelines.!##!Methods!#!A retrospective multicenter study was conducted by a German prostate cancer (PCa) working group representing six tertiary referral centers and one outpatient practice. Men with PCa and at least one MRI-visible lesion according to Prostate Imaging Reporting and Data System (PI-RADS) v2 were included. Twenty different AS inclusion criteria of international guidelines were applied to calculate AS eligibility using either a SB or a combined MRI-TB and SB. Reasons for AS exclusion were assessed.!##!Results!#!Of 1941 patients with PCa, per guideline, 583-1112 patients with PCa in both MRI-TB and SB were available for analysis. Using SB, a median of 22.1% (range 6.4-72.4%) were eligible for AS. Using the combined approach, a median of 15% (range 1.7-68.3%) were eligible for AS. Addition of MRI-TB led to a 32.1% reduction of suitable patients. Besides Gleason Score upgrading, the maximum number of positive cores were the most frequent exclusion criterion. Variability in MRI and biopsy protocols potentially limit the results.!##!Conclusions!#!Only a moderate number of patients with PCa can be monitored by AS to defer active treatment using current guidelines for inclusion in a real-world setting. By an additional MRI-TB, this number is markedly reduced. These results underline the need for a contemporary adjustment of AS inclusion criteria.
1000 Sacherschließung
lokal Watchful Waiting [MeSH]
lokal Article
lokal Image-Guided Biopsy/methods [MeSH]
lokal Male [MeSH]
lokal Prostate/pathology [MeSH]
lokal Humans [MeSH]
lokal Magnetic Resonance Imaging/methods [MeSH]
lokal Prostatic Neoplasms/pathology [MeSH]
lokal Retrospective Studies [MeSH]
lokal Prostatic Neoplasms/diagnostic imaging [MeSH]
lokal Prostate/diagnostic imaging [MeSH]
lokal Prostate cancer
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-9673-5030|https://frl.publisso.de/adhoc/uri/Qm9ya293ZXR6LCBBbmdlbGlrYQ==|https://frl.publisso.de/adhoc/uri/RHJlcnVwLCBNYXJ0aW4=|https://frl.publisso.de/adhoc/uri/TGllYiwgVmVyZW5h|https://frl.publisso.de/adhoc/uri/QnJ1ZW5kbCwgSm9oYW5uZXM=|https://frl.publisso.de/adhoc/uri/SMO2Zm5lciwgVGhvbWFz|https://frl.publisso.de/adhoc/uri/Q2FzaCwgSGFubmVz|https://frl.publisso.de/adhoc/uri/dm9uIEhhcmRlbmJlcmcsIEpvc3Q=|https://frl.publisso.de/adhoc/uri/QmV5ZXIsIEJ1cmtoYXJk|https://frl.publisso.de/adhoc/uri/QnLDvG5kbCwgSm9oYW5uZXM=|https://frl.publisso.de/adhoc/uri/Q2FzaCwgSm9oYW5uZXM=|https://frl.publisso.de/adhoc/uri/SGVycm1hbm4sIEpvbmFz|https://frl.publisso.de/adhoc/uri/UmFkdGtlLCBKYW4gUGhpbGlwcA==|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIE1hbnVlbGEgQS4=|https://frl.publisso.de/adhoc/uri/TGVpdHNtYW5uLCBDb25yYWQ=|https://frl.publisso.de/adhoc/uri/S29ybmllbmtvLCBLaXJh|https://frl.publisso.de/adhoc/uri/V29yc3QsIFRob21hcw==|https://frl.publisso.de/adhoc/uri/Qm9yZ21hbm4sIEhlbmRyaWs=|https://frl.publisso.de/adhoc/uri/TGlueHdlaWxlciwgSm9oYW5uZXM=|https://frl.publisso.de/adhoc/uri/S2zDvG1wZXIsIE5pa2xhcw==|https://frl.publisso.de/adhoc/uri/V2VuemVsLCBNaWtl|https://frl.publisso.de/adhoc/uri/V2VsdGUsIE1hcmlhIE5vZW1p|https://frl.publisso.de/adhoc/uri/V2VzdGhvZmYsIE5pa2xhcw==|https://frl.publisso.de/adhoc/uri/V8O8cm5zY2hpbW1lbCwgQ2hyaXN0b3Bo|https://frl.publisso.de/adhoc/uri/U2lnbGUsIEF1Z3VzdA==|https://frl.publisso.de/adhoc/uri/TWFoam91YiwgU2FteQ==|https://frl.publisso.de/adhoc/uri/T3J0bmVyLCBHZXJub3Q=|https://frl.publisso.de/adhoc/uri/S3dlLCBKZXJlbXk=|https://frl.publisso.de/adhoc/uri/TGFuZ2VuYmVyZ2VyLCBTdmVuLVRob3JiZW4=
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1000 Erstellt am 2023-04-26T16:23:46.804+0200
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1000 Zuletzt bearbeitet 2023-10-19T13:41:13.388+0200
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