Pretreatment central quality control for craniospinal irradiation in non-metastatic medulloblastoma

  1. Dietzsch, Stefan ORCID logo
  2. Braesigk, Annett
  3. Seidel, Clemens
  4. Remmele, Julia
  5. Kitzing, Ralf
  6. Schlender, Tina
  7. Mynarek, Martin
  8. Geismar, Dirk
  9. Jablonska, Karolina
  10. Schwarz, Rudolf
  11. Pazos, Montserrat
  12. Walser, Marc
  13. Frick, Silke
  14. Gurtner, Kristin
  15. Matuschek, Christiane
  16. Harrabi, Semi Ben
  17. Glück, Albrecht
  18. Lewitzki, Victor
  19. Dieckmann, Karin
  20. Benesch, Martin
  21. Gerber, Nicolas U.
  22. Rutkowski, Stefan
  23. Timmermann, Beate
  24. Kortmann, Rolf-Dieter

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1000 Titel
  • Pretreatment central quality control for craniospinal irradiation in non-metastatic medulloblastoma
1000 Autor/in
  1. Dietzsch, Stefan |
  2. Braesigk, Annett |
  3. Seidel, Clemens |
  4. Remmele, Julia |
  5. Kitzing, Ralf |
  6. Schlender, Tina |
  7. Mynarek, Martin |
  8. Geismar, Dirk |
  9. Jablonska, Karolina |
  10. Schwarz, Rudolf |
  11. Pazos, Montserrat |
  12. Walser, Marc |
  13. Frick, Silke |
  14. Gurtner, Kristin |
  15. Matuschek, Christiane |
  16. Harrabi, Semi Ben |
  17. Glück, Albrecht |
  18. Lewitzki, Victor |
  19. Dieckmann, Karin |
  20. Benesch, Martin |
  21. Gerber, Nicolas U. |
  22. Rutkowski, Stefan |
  23. Timmermann, Beate |
  24. Kortmann, Rolf-Dieter |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-11-23
1000 Erschienen in
1000 Quellenangabe
  • 197(8):674-682
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00066-020-01707-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292275/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!Several studies have demonstrated the negative impact of radiotherapy protocol deviations on tumor control in medulloblastoma. In the SIOP PNET5 MB trial, a pretreatment radiotherapy quality control (RT-QC) program was introduced. A first analysis for patients enrolled in Germany, Switzerland and Austria with focus on types of deviations in the initial plan proposals and review criteria for modern radiation technologies was performed.!##!Methods and patients!#!Sixty-nine craniospinal irradiation (CSI) plans were available for detailed analyses. RT-QC was performed according to protocol definitions on dose uniformity. Because of the lack of definitions for high-precision 3D conformal radiotherapy within the protocol, additional criteria for RT-QC on delineation and coverage of clinical target volume (CTV) and planning target volume (PTV) were defined and evaluated.!##!Results!#!Target volume (CTV/PTV) deviations occurred in 49.3% of initial CSI plan proposals (33.3% minor, 15.9% major). Dose uniformity deviations were less frequent (43.5%). Modification of the RT plan was recommended in 43.5% of CSI plans. Unacceptable RT plans were predominantly related to incorrect target delineation rather than dose uniformity. Unacceptable plans were negatively correlated to the number of enrolled patients per institution with a cutoff of 5 patients (p = 0.001).!##!Conclusion!#!This prospective pretreatment individual case review study revealed a high rate of deviations and emphasizes the strong need of pretreatment RT-QC in clinical trials for medulloblastoma. Furthermore, the experiences point out the necessity of new RT-QC criteria for high-precision CSI techniques.
1000 Sacherschließung
lokal Adolescent [MeSH]
lokal Female [MeSH]
lokal Cerebellar Neoplasms/radiotherapy [MeSH]
lokal Review criteria
lokal Medulloblastoma/radiotherapy [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal Craniospinal Irradiation/methods [MeSH]
lokal Quality Control [MeSH]
lokal Radiation Oncology [MeSH]
lokal Cohort Studies [MeSH]
lokal Original Article
lokal Male [MeSH]
lokal Brain tumor
lokal Germany [MeSH]
lokal Young Adult [MeSH]
lokal Child [MeSH]
lokal Deviation
lokal Pediatric
lokal Quality assurance
lokal Child, Preschool [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2023-04-26T17:41:28.957+0200
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1000 Zuletzt bearbeitet 2023-10-19T14:13:45.239+0200
1000 Objekt bearb. Thu Oct 19 14:13:45 CEST 2023
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