Accuracy and precision of volumetric bone mineral density assessment using dual-source dual-energy versus quantitative CT: a phantom study

  1. Koch, Vitali
  2. Hokamp, Nils Große
  3. Albrecht, Moritz ORCID logo
  4. Gruenewald, Leon D.
  5. Yel, Ibrahim
  6. Borggrefe, Jan
  7. Wesarg, Stefan
  8. Eichler, Katrin
  9. Burck, Iris
  10. Gruber-Rouh, Tatjana
  11. Lenga, Lukas
  12. Vogl, Thomas J.
  13. Martin, Simon S.
  14. Wichmann, Julian L.
  15. Hammerstingl, Renate M.
  16. Alizadeh, Leona S.
  17. Mader, Christoph
  18. Huizinga, Nicole A.
  19. D’Angelo, Tommaso
  20. Ascenti, Giorgio
  21. Mazziotti, Silvio
  22. Booz, Christian

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1000 Titel
  • Accuracy and precision of volumetric bone mineral density assessment using dual-source dual-energy versus quantitative CT: a phantom study
1000 Autor/in
  1. Koch, Vitali |
  2. Hokamp, Nils Große |
  3. Albrecht, Moritz |
  4. Gruenewald, Leon D. |
  5. Yel, Ibrahim |
  6. Borggrefe, Jan |
  7. Wesarg, Stefan |
  8. Eichler, Katrin |
  9. Burck, Iris |
  10. Gruber-Rouh, Tatjana |
  11. Lenga, Lukas |
  12. Vogl, Thomas J. |
  13. Martin, Simon S. |
  14. Wichmann, Julian L. |
  15. Hammerstingl, Renate M. |
  16. Alizadeh, Leona S. |
  17. Mader, Christoph |
  18. Huizinga, Nicole A. |
  19. D’Angelo, Tommaso |
  20. Ascenti, Giorgio |
  21. Mazziotti, Silvio |
  22. Booz, Christian |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-10-05
1000 Erschienen in
1000 Quellenangabe
  • 5(1):43
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s41747-021-00241-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490583/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Dual-source dual-energy computed tomography (DECT) offers the potential for opportunistic osteoporosis screening by enabling phantomless bone mineral density (BMD) quantification. This study sought to assess the accuracy and precision of volumetric BMD measurement using dual-source DECT in comparison to quantitative CT (QCT).!##!Methods!#!A validated spine phantom consisting of three lumbar vertebra equivalents with 50 (L1), 100 (L2), and 200 mg/cm!##!Results!#!DECT-derived BMD values differed significantly from those obtained by QCT (p < 0.001) and were found to be closer to true HA concentrations. Relative measurement errors were significantly smaller for DECT in comparison to QCT (L1, 0.94% versus 9.68%; L2, 0.28% versus 5.74%; L3, 0.24% versus 3.67%, respectively). DECT demonstrated better BMD measurement repeatability compared to QCT (coefficient of variance < 4.29% for DECT, < 6.74% for QCT). Both methods correlated well to each other (r = 0.9993; 95% confidence interval 0.9984-0.9997; p < 0.001) and revealed substantial agreement in Bland-Altman plots.!##!Conclusions!#!Phantomless dual-source DECT-based BMD assessment of lumbar vertebra equivalents using material decomposition showed higher diagnostic accuracy compared to QCT.
1000 Sacherschließung
lokal Original Article
lokal Tomography, X-Ray Computed [MeSH]
lokal Bone Density [MeSH]
lokal Absorptiometry, Photon [MeSH]
lokal Phantoms, Imaging [MeSH]
lokal Bone density
lokal Dual-energy computed tomography
lokal Tomography (x-ray computed)
lokal Lumbar Vertebrae/diagnostic imaging [MeSH]
lokal Osteoporosis
lokal Phantoms (imaging)
1000 Liste der Beteiligten
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