Genetically determined telomere length and multiple myeloma risk and outcome

  1. Giaccherini, Matteo ORCID logo
  2. Macauda, Angelica
  3. Orciuolo, Enrico
  4. Rymko, Marcin
  5. Gruenpeter, Karolina
  6. Dumontet, Charles
  7. Raźny, Malgorzata
  8. Moreno, Victor ORCID logo
  9. Buda, Gabriele
  10. Beider, Katia
  11. Varkonyi, Judit
  12. Avet-Loiseau, Hervé
  13. Martinez-Lopez, Joaquin ORCID logo
  14. Marques, Herlander
  15. Watek, Marzena
  16. Sarasquete, Maria Eugenia ORCID logo
  17. Andersen, Vibeke
  18. Karlin, Lionel
  19. Suska, Anna
  20. Kruszewski, Marcin
  21. Abildgaard, Niels
  22. Dudziński, Marek
  23. Butrym, Aleksandra
  24. Nagler, Arnold
  25. Vangsted, Annette Juul ORCID logo
  26. Kadar, Katalin
  27. Tomczak, Waldemar ORCID logo
  28. Jamroziak, Krzysztof
  29. Jacobsen, Svend Erik Hove
  30. Ebbesen, Lene Hyldahl
  31. Taszner, Michał ORCID logo
  32. Mazur, Grzegorz ORCID logo
  33. Lesueur, Fabienne
  34. Pelosini, Matteo
  35. Garcia-Sanz, Ramon ORCID logo
  36. Jurczyszyn, Artur ORCID logo
  37. Demangel, Delphine
  38. Reis, Rui Manuel
  39. Iskierka-Jażdżewska, Elżbieta
  40. Markiewicz, Miroslaw ORCID logo
  41. Gemignani, Federica
  42. Subocz, Edyta
  43. Zawirska, Daria
  44. Druzd-Sitek, Agnieszka
  45. Stępień, Anna
  46. Alonso, M. Henar
  47. SAINZ, JUAN ORCID logo
  48. Canzian, Federico ORCID logo
  49. Campa, Daniele

Download
s41408-021-00462-y.pdf 676,37KB
WeightNameValue
1000 Titel
  • Genetically determined telomere length and multiple myeloma risk and outcome
1000 Autor/in
  1. Giaccherini, Matteo |
  2. Macauda, Angelica |
  3. Orciuolo, Enrico |
  4. Rymko, Marcin |
  5. Gruenpeter, Karolina |
  6. Dumontet, Charles |
  7. Raźny, Malgorzata |
  8. Moreno, Victor |
  9. Buda, Gabriele |
  10. Beider, Katia |
  11. Varkonyi, Judit |
  12. Avet-Loiseau, Hervé |
  13. Martinez-Lopez, Joaquin |
  14. Marques, Herlander |
  15. Watek, Marzena |
  16. Sarasquete, Maria Eugenia |
  17. Andersen, Vibeke |
  18. Karlin, Lionel |
  19. Suska, Anna |
  20. Kruszewski, Marcin |
  21. Abildgaard, Niels |
  22. Dudziński, Marek |
  23. Butrym, Aleksandra |
  24. Nagler, Arnold |
  25. Vangsted, Annette Juul |
  26. Kadar, Katalin |
  27. Tomczak, Waldemar |
  28. Jamroziak, Krzysztof |
  29. Jacobsen, Svend Erik Hove |
  30. Ebbesen, Lene Hyldahl |
  31. Taszner, Michał |
  32. Mazur, Grzegorz |
  33. Lesueur, Fabienne |
  34. Pelosini, Matteo |
  35. Garcia-Sanz, Ramon |
  36. Jurczyszyn, Artur |
  37. Demangel, Delphine |
  38. Reis, Rui Manuel |
  39. Iskierka-Jażdżewska, Elżbieta |
  40. Markiewicz, Miroslaw |
  41. Gemignani, Federica |
  42. Subocz, Edyta |
  43. Zawirska, Daria |
  44. Druzd-Sitek, Agnieszka |
  45. Stępień, Anna |
  46. Alonso, M. Henar |
  47. SAINZ, JUAN |
  48. Canzian, Federico |
  49. Campa, Daniele |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-14
1000 Erschienen in
1000 Quellenangabe
  • 11(4):74
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41408-021-00462-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046773/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Telomeres are involved in processes like cellular growth, chromosomal stability, and proper segregation to daughter cells. Telomere length measured in leukocytes (LTL) has been investigated in different cancer types, including multiple myeloma (MM). However, LTL measurement is prone to heterogeneity due to sample handling and study design (retrospective vs. prospective). LTL is genetically determined; genome-wide association studies identified 11 SNPs that, combined in a score, can be used as a genetic instrument to measure LTL and evaluate its association with MM risk. This approach has been already successfully attempted in various cancer types but never in MM. We tested the 'teloscore' in 2407 MM patients and 1741 controls from the International Multiple Myeloma rESEarch (IMMeNSE) consortium. We observed an increased risk for longer genetically determined telomere length (gdTL) (OR = 1.69; 95% CI 1.36-2.11; P = 2.97 × 10
1000 Sacherschließung
lokal Genetic Predisposition to Disease [MeSH]
lokal Female [MeSH]
lokal Aged [MeSH]
lokal Polymorphism, Single Nucleotide [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal Telomere Homeostasis [MeSH]
lokal Retrospective Studies [MeSH]
lokal Middle Aged [MeSH]
lokal Multiple Myeloma/genetics [MeSH]
lokal Risk factors
lokal Genome-Wide Association Study [MeSH]
lokal Article
lokal Male [MeSH]
lokal Prognosis [MeSH]
lokal Myeloma
lokal Telomere/genetics [MeSH]
lokal Multiple Myeloma/diagnosis [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-0363-6632|https://frl.publisso.de/adhoc/uri/TWFjYXVkYSwgQW5nZWxpY2E=|https://frl.publisso.de/adhoc/uri/T3JjaXVvbG8sIEVucmljbw==|https://frl.publisso.de/adhoc/uri/Unlta28sIE1hcmNpbg==|https://frl.publisso.de/adhoc/uri/R3J1ZW5wZXRlciwgS2Fyb2xpbmE=|https://frl.publisso.de/adhoc/uri/RHVtb250ZXQsIENoYXJsZXM=|https://frl.publisso.de/adhoc/uri/UmHFum55LCBNYWxnb3J6YXRh|https://orcid.org/0000-0002-2818-5487|https://frl.publisso.de/adhoc/uri/QnVkYSwgR2FicmllbGU=|https://frl.publisso.de/adhoc/uri/QmVpZGVyLCBLYXRpYQ==|https://frl.publisso.de/adhoc/uri/VmFya29ueWksIEp1ZGl0|https://frl.publisso.de/adhoc/uri/QXZldC1Mb2lzZWF1LCBIZXJ2w6k=|https://orcid.org/0000-0001-7908-0063|https://frl.publisso.de/adhoc/uri/TWFycXVlcywgSGVybGFuZGVy|https://frl.publisso.de/adhoc/uri/V2F0ZWssIE1hcnplbmE=|https://orcid.org/0000-0001-7335-3657|https://frl.publisso.de/adhoc/uri/QW5kZXJzZW4sIFZpYmVrZQ==|https://frl.publisso.de/adhoc/uri/S2FybGluLCBMaW9uZWw=|https://frl.publisso.de/adhoc/uri/U3Vza2EsIEFubmE=|https://frl.publisso.de/adhoc/uri/S3J1c3pld3NraSwgTWFyY2lu|https://frl.publisso.de/adhoc/uri/QWJpbGRnYWFyZCwgTmllbHM=|https://frl.publisso.de/adhoc/uri/RHVkemnFhHNraSwgTWFyZWs=|https://frl.publisso.de/adhoc/uri/QnV0cnltLCBBbGVrc2FuZHJh|https://frl.publisso.de/adhoc/uri/TmFnbGVyLCBBcm5vbGQ=|https://orcid.org/0000-0002-2131-731X|https://frl.publisso.de/adhoc/uri/S2FkYXIsIEthdGFsaW4=|https://orcid.org/0000-0002-3205-5781|https://frl.publisso.de/adhoc/uri/SmFtcm96aWFrLCBLcnp5c3p0b2Y=|https://frl.publisso.de/adhoc/uri/SmFjb2JzZW4sIFN2ZW5kIEVyaWsgSG92ZQ==|https://frl.publisso.de/adhoc/uri/RWJiZXNlbiwgTGVuZSBIeWxkYWhs|https://orcid.org/0000-0002-8437-2797|https://orcid.org/0000-0001-6610-2008|https://frl.publisso.de/adhoc/uri/TGVzdWV1ciwgRmFiaWVubmU=|https://frl.publisso.de/adhoc/uri/UGVsb3NpbmksIE1hdHRlbw==|https://orcid.org/0000-0003-4120-2787|https://orcid.org/0000-0001-9796-8365|https://frl.publisso.de/adhoc/uri/RGVtYW5nZWwsIERlbHBoaW5l|https://frl.publisso.de/adhoc/uri/UmVpcywgUnVpIE1hbnVlbA==|https://frl.publisso.de/adhoc/uri/SXNraWVya2EtSmHFvGTFvGV3c2thLCBFbMW8YmlldGE=|https://orcid.org/0000-0002-8550-8908|https://frl.publisso.de/adhoc/uri/R2VtaWduYW5pLCBGZWRlcmljYQ==|https://frl.publisso.de/adhoc/uri/U3Vib2N6LCBFZHl0YQ==|https://frl.publisso.de/adhoc/uri/WmF3aXJza2EsIERhcmlh|https://frl.publisso.de/adhoc/uri/RHJ1emQtU2l0ZWssIEFnbmllc3prYQ==|https://frl.publisso.de/adhoc/uri/U3TEmXBpZcWELCBBbm5h|https://frl.publisso.de/adhoc/uri/QWxvbnNvLCBNLiBIZW5hcg==|https://orcid.org/0000-0002-9355-2423|https://orcid.org/0000-0002-4261-4583|https://frl.publisso.de/adhoc/uri/Q2FtcGEsIERhbmllbGU=
1000 Hinweis
  • DeepGreen-ID: 1e1c6c3f2a8a419680f3c7602005f36e ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6443590.rdf
1000 Erstellt am 2023-04-27T09:57:19.207+0200
1000 Erstellt von 322
1000 beschreibt frl:6443590
1000 Zuletzt bearbeitet Thu Oct 19 15:09:58 CEST 2023
1000 Objekt bearb. Thu Oct 19 15:09:58 CEST 2023
1000 Vgl. frl:6443590
1000 Oai Id
  1. oai:frl.publisso.de:frl:6443590 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source