Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients

  1. Schubert, Klaus Oliver ORCID logo
  2. Thalamuthu, Anbupalam
  3. Amare, Azmeraw T. ORCID logo
  4. Frank, Josef ORCID logo
  5. Streit, Fabian ORCID logo
  6. Adl, Mazda
  7. Akula, Nirmala
  8. Akiyama, Kazufumi
  9. Ardau, Raffaella
  10. Arias, Bárbara
  11. Aubry, Jean-Michel
  12. Backlund, Lena
  13. Bhattacharjee, Abesh Kumar
  14. Bellivier, Frank
  15. Benabarre, Antonio
  16. Bengesser, Susanne
  17. Biernacka, Joanna ORCID logo
  18. Birner, Armin
  19. Marie-Claire, Cynthia
  20. Cearns, Micah
  21. Cervantes, Pablo
  22. Chen, Hsi-Chung
  23. Chillotti, Caterina
  24. Cichon, Sven
  25. Clark, Scott Richard ORCID logo
  26. Cruceanu, Cristiana ORCID logo
  27. Czerski, Piotr M. ORCID logo
  28. Dalkner, Nina
  29. Dayer, Alexandre
  30. Degenhardt, Franziska
  31. DEL ZOMPO, MARIA ORCID logo
  32. DePaulo, J. Raymond
  33. Étain, Bruno
  34. Falkai, Peter
  35. Forstner, Andreas J ORCID logo
  36. Frisen, Louise
  37. Frye, Mark ORCID logo
  38. Fullerton, Janice ORCID logo
  39. Gard, Sébastien
  40. Garnham, Julie ORCID logo
  41. Goes, Fernando S.
  42. Grigoroiu-Serbanescu, Maria ORCID logo
  43. Grof, Paul
  44. Hashimoto, Ryota
  45. Hauser, Joanna ORCID logo
  46. Heilbronner, Urs ORCID logo
  47. Herms, Stefan ORCID logo
  48. Hoffmann, Per
  49. Hou, Liping ORCID logo
  50. Hsu, Yi-Hsiang
  51. Jamain, Stéphane ORCID logo
  52. Jiménez, Esther
  53. Kahn, Jean-Pierre
  54. Kassem, Layla
  55. Kuo, Po-Hsiu
  56. Kato, Tadafumi
  57. Kelsoe, John ORCID logo
  58. Kittel-Schneider, Sarah
  59. Ferensztajn-Rochowiak, Ewa
  60. König, Barbara
  61. Kusumi, Ichiro ORCID logo
  62. Laje, Gonzalo
  63. Landén, Mikael ORCID logo
  64. Lavebratt, Catharina ORCID logo
  65. LEBOYER, Marion ORCID logo
  66. Leckband, Susan G.
  67. Maj, Mario
  68. Manchia, Mirko
  69. Martinsson, Lina
  70. McCarthy, Michael J.
  71. McElroy, Susan
  72. Colom, Francesc
  73. Mitjans, Marina
  74. Mondimore, Francis M.
  75. Monteleone, Palmiero
  76. Nievergelt, Caroline ORCID logo
  77. Nöthen, Markus ORCID logo
  78. Novák, Tomáš ORCID logo
  79. O’Donovan, Claire
  80. Ozaki, Norio ORCID logo
  81. Ösby, Urban
  82. Papiol, Sergi ORCID logo
  83. Pfennig, Andrea
  84. Pisanu, Claudia ORCID logo
  85. Potash, James B.
  86. Reif, Andreas ORCID logo
  87. Reininghaus, Eva
  88. Rouleau, Guy ORCID logo
  89. Rybakowski, Janusz K.
  90. Schalling, Martin
  91. Schofield, Peter ORCID logo
  92. Schweizer, Barbara W.
  93. SEVERINO, GIOVANNI ORCID logo
  94. Shekhtman, Tatyana
  95. Shilling, Paul ORCID logo
  96. SHIMODA, KAZUTAKA ORCID logo
  97. Simhandl, Christian
  98. Slaney, Claire M.
  99. Squassina, Alessio ORCID logo
  100. Stamm, Thomas
  101. Stopkova, Pavla
  102. Tekola-Ayele, Fasil
  103. Tortorella, Alfonso
  104. Turecki, Gustavo ORCID logo
  105. Veeh, Julia
  106. Vieta, Eduard
  107. Witt, Stephanie ORCID logo
  108. Roberts, Gloria
  109. Zandi, Peter P.
  110. Alda, Martin ORCID logo
  111. Bauer, Michael ORCID logo
  112. McMahon, Francis ORCID logo
  113. Mitchell, Philip ORCID logo
  114. Schulze, Thomas G. ORCID logo
  115. Rietschel, Marcella ORCID logo
  116. Baune, Bernhard T ORCID logo

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1000 Titel
  • Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
1000 Autor/in
  1. Schubert, Klaus Oliver |
  2. Thalamuthu, Anbupalam |
  3. Amare, Azmeraw T. |
  4. Frank, Josef |
  5. Streit, Fabian |
  6. Adl, Mazda |
  7. Akula, Nirmala |
  8. Akiyama, Kazufumi |
  9. Ardau, Raffaella |
  10. Arias, Bárbara |
  11. Aubry, Jean-Michel |
  12. Backlund, Lena |
  13. Bhattacharjee, Abesh Kumar |
  14. Bellivier, Frank |
  15. Benabarre, Antonio |
  16. Bengesser, Susanne |
  17. Biernacka, Joanna |
  18. Birner, Armin |
  19. Marie-Claire, Cynthia |
  20. Cearns, Micah |
  21. Cervantes, Pablo |
  22. Chen, Hsi-Chung |
  23. Chillotti, Caterina |
  24. Cichon, Sven |
  25. Clark, Scott Richard |
  26. Cruceanu, Cristiana |
  27. Czerski, Piotr M. |
  28. Dalkner, Nina |
  29. Dayer, Alexandre |
  30. Degenhardt, Franziska |
  31. DEL ZOMPO, MARIA |
  32. DePaulo, J. Raymond |
  33. Étain, Bruno |
  34. Falkai, Peter |
  35. Forstner, Andreas J |
  36. Frisen, Louise |
  37. Frye, Mark |
  38. Fullerton, Janice |
  39. Gard, Sébastien |
  40. Garnham, Julie |
  41. Goes, Fernando S. |
  42. Grigoroiu-Serbanescu, Maria |
  43. Grof, Paul |
  44. Hashimoto, Ryota |
  45. Hauser, Joanna |
  46. Heilbronner, Urs |
  47. Herms, Stefan |
  48. Hoffmann, Per |
  49. Hou, Liping |
  50. Hsu, Yi-Hsiang |
  51. Jamain, Stéphane |
  52. Jiménez, Esther |
  53. Kahn, Jean-Pierre |
  54. Kassem, Layla |
  55. Kuo, Po-Hsiu |
  56. Kato, Tadafumi |
  57. Kelsoe, John |
  58. Kittel-Schneider, Sarah |
  59. Ferensztajn-Rochowiak, Ewa |
  60. König, Barbara |
  61. Kusumi, Ichiro |
  62. Laje, Gonzalo |
  63. Landén, Mikael |
  64. Lavebratt, Catharina |
  65. LEBOYER, Marion |
  66. Leckband, Susan G. |
  67. Maj, Mario |
  68. Manchia, Mirko |
  69. Martinsson, Lina |
  70. McCarthy, Michael J. |
  71. McElroy, Susan |
  72. Colom, Francesc |
  73. Mitjans, Marina |
  74. Mondimore, Francis M. |
  75. Monteleone, Palmiero |
  76. Nievergelt, Caroline |
  77. Nöthen, Markus |
  78. Novák, Tomáš |
  79. O’Donovan, Claire |
  80. Ozaki, Norio |
  81. Ösby, Urban |
  82. Papiol, Sergi |
  83. Pfennig, Andrea |
  84. Pisanu, Claudia |
  85. Potash, James B. |
  86. Reif, Andreas |
  87. Reininghaus, Eva |
  88. Rouleau, Guy |
  89. Rybakowski, Janusz K. |
  90. Schalling, Martin |
  91. Schofield, Peter |
  92. Schweizer, Barbara W. |
  93. SEVERINO, GIOVANNI |
  94. Shekhtman, Tatyana |
  95. Shilling, Paul |
  96. SHIMODA, KAZUTAKA |
  97. Simhandl, Christian |
  98. Slaney, Claire M. |
  99. Squassina, Alessio |
  100. Stamm, Thomas |
  101. Stopkova, Pavla |
  102. Tekola-Ayele, Fasil |
  103. Tortorella, Alfonso |
  104. Turecki, Gustavo |
  105. Veeh, Julia |
  106. Vieta, Eduard |
  107. Witt, Stephanie |
  108. Roberts, Gloria |
  109. Zandi, Peter P. |
  110. Alda, Martin |
  111. Bauer, Michael |
  112. McMahon, Francis |
  113. Mitchell, Philip |
  114. Schulze, Thomas G. |
  115. Rietschel, Marcella |
  116. Baune, Bernhard T |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-11-29
1000 Erschienen in
1000 Quellenangabe
  • 11(1):606
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-021-01702-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630000/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Lithium is the gold standard therapy for Bipolar Disorder (BD) but its effectiveness differs widely between individuals. The molecular mechanisms underlying treatment response heterogeneity are not well understood, and personalized treatment in BD remains elusive. Genetic analyses of the lithium treatment response phenotype may generate novel molecular insights into lithium's therapeutic mechanisms and lead to testable hypotheses to improve BD management and outcomes. We used fixed effect meta-analysis techniques to develop meta-analytic polygenic risk scores (MET-PRS) from combinations of highly correlated psychiatric traits, namely schizophrenia (SCZ), major depression (MD) and bipolar disorder (BD). We compared the effects of cross-disorder MET-PRS and single genetic trait PRS on lithium response. For the PRS analyses, we included clinical data on lithium treatment response and genetic information for n = 2283 BD cases from the International Consortium on Lithium Genetics (ConLi
1000 Sacherschließung
lokal Genetic Predisposition to Disease [MeSH]
lokal Humans [MeSH]
lokal Depressive Disorder, Major/drug therapy [MeSH]
lokal Pharmacogenomics
lokal Bipolar disorder
lokal Bipolar Disorder/drug therapy [MeSH]
lokal Depressive Disorder, Major/genetics [MeSH]
lokal Schizophrenia/drug therapy [MeSH]
lokal Risk Factors [MeSH]
lokal Multifactorial Inheritance [MeSH]
lokal Bipolar Disorder/genetics [MeSH]
lokal Depression [MeSH]
lokal Schizophrenia/genetics [MeSH]
lokal Article
lokal Lithium/therapeutic use [MeSH]
1000 Liste der Beteiligten
  1. 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