Download
s41398-021-01627-w.pdf 8,01MB
WeightNameValue
1000 Titel
  • Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501
1000 Autor/in
  1. Goldberg, Maria |
  2. Islam, Md. Rezaul |
  3. Kerimoglu, Cemil |
  4. Lancelin, Camille |
  5. Gisa, Verena |
  6. Burkhardt, Susanne |
  7. Krüger, Dennis M. |
  8. Marquardt, Till |
  9. Malchow, Berend |
  10. Schmitt, Andrea |
  11. Falkai, Peter |
  12. Sananbenesi, Farahnaz |
  13. Fischer, Andre |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-10-08
1000 Erschienen in
1000 Quellenangabe
  • 11(1):514
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-021-01627-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501071/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • MicroRNAs have been linked to synaptic plasticity and memory function and are emerging as potential biomarkers and therapeutic targets for cognitive diseases. Most of these data stem from the analysis of model systems or postmortem tissue from patients which mainly represents an advanced stage of pathology. Due to the in-accessibility of human brain tissue upon experimental manipulation, it is still challenging to identify microRNAs relevant to human cognition, which is however a key step for future translational studies. Here, we employ exercise as an experimental model for memory enhancement in healthy humans with the aim to identify microRNAs linked to memory function. By analyzing the circulating smallRNAome we find a cluster of 18 microRNAs that are highly correlated to cognition. MicroRNA-409-5p and microRNA-501-3p were the most significantly regulated candidates. Functional analysis revealed that the two microRNAs are important for neuronal integrity, synaptic plasticity, and morphology. In conclusion, we provide a novel approach to identify microRNAs linked to human memory function.
1000 Sacherschließung
lokal Article
lokal Humans [MeSH]
lokal Molecular neuroscience
lokal Neuronal Plasticity [MeSH]
lokal Biomarkers [MeSH]
lokal MicroRNAs/genetics [MeSH]
lokal Cognition [MeSH]
lokal Epigenetics and behaviour
lokal Exercise [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/R29sZGJlcmcsIE1hcmlh|https://orcid.org/0000-0003-4037-3293|https://frl.publisso.de/adhoc/uri/S2VyaW1vZ2x1LCBDZW1pbA==|https://orcid.org/0000-0003-1954-4086|https://frl.publisso.de/adhoc/uri/R2lzYSwgVmVyZW5h|https://frl.publisso.de/adhoc/uri/QnVya2hhcmR0LCBTdXNhbm5l|https://frl.publisso.de/adhoc/uri/S3LDvGdlciwgRGVubmlzIE0u|https://frl.publisso.de/adhoc/uri/TWFycXVhcmR0LCBUaWxs|https://frl.publisso.de/adhoc/uri/TWFsY2hvdywgQmVyZW5k|https://frl.publisso.de/adhoc/uri/U2NobWl0dCwgQW5kcmVh|https://frl.publisso.de/adhoc/uri/RmFsa2FpLCBQZXRlcg==|https://frl.publisso.de/adhoc/uri/U2FuYW5iZW5lc2ksIEZhcmFobmF6|https://orcid.org/0000-0001-8546-1161
1000 Hinweis
  • DeepGreen-ID: 7f2ce82ca8074f7e8a3d9cdd1a50a7c8 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6443614.rdf
1000 Erstellt am 2023-04-27T10:04:26.965+0200
1000 Erstellt von 322
1000 beschreibt frl:6443614
1000 Zuletzt bearbeitet 2023-10-19T15:13:13.883+0200
1000 Objekt bearb. Thu Oct 19 15:13:13 CEST 2023
1000 Vgl. frl:6443614
1000 Oai Id
  1. oai:frl.publisso.de:frl:6443614 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source