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1000 Titel
  • Structure-function relationships of the disease-linked A218T oxytocin receptor variant
1000 Autor/in
  1. Meyer, Magdalena |
  2. Jurek, Benjamin |
  3. Alfonso-Prieto, Mercedes |
  4. Ribeiro, Rui |
  5. Milenkovic, Vladimir M. |
  6. Winter, Julia J |
  7. Hoffmann, Petra |
  8. Wetzel, Christian |
  9. Giorgetti, Alejandro |
  10. Carloni, Paolo |
  11. Neumann, Inga D |
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-01-04
1000 Erschienen in
1000 Quellenangabe
  • 27(2):907-917
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41380-021-01241-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054668/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Various single nucleotide polymorphisms (SNPs) in the oxytocin receptor (OXTR) gene have been associated with behavioral traits, autism spectrum disorder (ASD) and other diseases. The non-synonymous SNP rs4686302 results in the OXTR variant A218T and has been linked to core characteristics of ASD, trait empathy and preterm birth. However, the molecular and intracellular mechanisms underlying those associations are still elusive. Here, we uncovered the molecular and intracellular consequences of this mutation that may affect the psychological or behavioral outcome of oxytocin (OXT)-treatment regimens in clinical studies, and provide a mechanistic explanation for an altered receptor function. We created two monoclonal HEK293 cell lines, stably expressing either the wild-type or A218T OXTR. We detected an increased OXTR protein stability, accompanied by a shift in Ca
1000 Sacherschließung
lokal ADHD
lokal Infant, Newborn [MeSH]
lokal Female [MeSH]
lokal Autism Spectrum Disorder/drug therapy [MeSH]
lokal Neuroscience
lokal Receptors, Oxytocin/genetics [MeSH]
lokal Humans [MeSH]
lokal Structure-Activity Relationship [MeSH]
lokal Receptors, Oxytocin/metabolism [MeSH]
lokal Autism spectrum disorders
lokal Molecular biology
lokal Article
lokal HEK293 Cells [MeSH]
lokal Psychology
lokal Oxytocin/metabolism [MeSH]
lokal Pregnancy [MeSH]
lokal Premature Birth/drug therapy [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-5388-3850|https://orcid.org/0000-0001-7124-510X|https://orcid.org/0000-0003-4509-4517|https://frl.publisso.de/adhoc/uri/UmliZWlybywgUnVp|https://frl.publisso.de/adhoc/uri/TWlsZW5rb3ZpYywgVmxhZGltaXIgTS4=|https://orcid.org/0000-0001-8518-0167|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIFBldHJh|https://orcid.org/0000-0002-5762-0003|https://frl.publisso.de/adhoc/uri/R2lvcmdldHRpLCBBbGVqYW5kcm8=|https://frl.publisso.de/adhoc/uri/Q2FybG9uaSwgUGFvbG8=|https://orcid.org/0000-0002-3911-5062
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  • DeepGreen-ID: cbff3a2cc22d46abbadb15b3c7c8417f ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-04-27T10:35:42.296+0200
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1000 Zuletzt bearbeitet Fri Oct 20 07:57:34 CEST 2023
1000 Objekt bearb. Fri Oct 20 07:57:34 CEST 2023
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