Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization

  1. Sha, Zhiqiang
  2. Schijven, Dick ORCID logo
  3. Francks, Clyde ORCID logo

Download
s41380-021-01204-z.pdf 1,65MB
WeightNameValue
1000 Titel
  • Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization
1000 Autor/in
  1. Sha, Zhiqiang |
  2. Schijven, Dick |
  3. Francks, Clyde |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-01
1000 Erschienen in
1000 Quellenangabe
  • 26(12):7652-7660
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41380-021-01204-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872997/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Autism spectrum disorder (ASD) and schizophrenia have been conceived as partly opposing disorders in terms of systemizing vs. empathizing cognitive styles, with resemblances to male vs. female average sex differences. Left-right asymmetry of the brain is an important aspect of its organization that shows average differences between the sexes and can be altered in both ASD and schizophrenia. Here we mapped multivariate associations of polygenic risk scores for ASD and schizophrenia with asymmetries of regional cerebral cortical surface area, thickness, and subcortical volume measures in 32,256 participants from the UK Biobank. Polygenic risks for the two disorders were positively correlated (r = 0.08, p = 7.13 × 10
1000 Sacherschließung
lokal Female [MeSH]
lokal Executive Function [MeSH]
lokal Neuroscience
lokal Language [MeSH]
lokal Humans [MeSH]
lokal Schizophrenia
lokal Brain [MeSH]
lokal Autism Spectrum Disorder [MeSH]
lokal Autistic Disorder/complications [MeSH]
lokal Autism spectrum disorders
lokal Magnetic Resonance Imaging [MeSH]
lokal Schizophrenia/genetics [MeSH]
lokal Article
lokal Male [MeSH]
lokal Genetics
lokal Schizophrenia/complications [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2hhLCBaaGlxaWFuZw==|https://orcid.org/0000-0001-5190-7241|https://orcid.org/0000-0002-9098-890X
1000 Hinweis
  • DeepGreen-ID: 58edb4813aa74ed4bca5b4909f6ecf30 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6443746.rdf
1000 Erstellt am 2023-04-27T10:37:19.941+0200
1000 Erstellt von 322
1000 beschreibt frl:6443746
1000 Zuletzt bearbeitet 2023-10-20T07:58:24.480+0200
1000 Objekt bearb. Fri Oct 20 07:58:24 CEST 2023
1000 Vgl. frl:6443746
1000 Oai Id
  1. oai:frl.publisso.de:frl:6443746 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source