Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity

  1. Kruyer, Anna ORCID logo
  2. Parrilla-Carrero, Jeffrey
  3. Powell, Courtney
  4. Brandt, Lasse
  5. Gutwinski, Stefan
  6. Angelis, Ariana
  7. Chalhoub, Reda M.
  8. Jhou, Thomas C.
  9. Kalivas, Peter ORCID logo
  10. Amato, Davide ORCID logo

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1000 Titel
  • Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity
1000 Autor/in
  1. Kruyer, Anna |
  2. Parrilla-Carrero, Jeffrey |
  3. Powell, Courtney |
  4. Brandt, Lasse |
  5. Gutwinski, Stefan |
  6. Angelis, Ariana |
  7. Chalhoub, Reda M. |
  8. Jhou, Thomas C. |
  9. Kalivas, Peter |
  10. Amato, Davide |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-08-04
1000 Erschienen in
1000 Quellenangabe
  • 26(11):6159-6169
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41380-021-01235-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760070/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Antipsychotic-induced dopamine supersensitivity, or behavioral supersensitivity, is a problematic consequence of long-term antipsychotic treatment characterized by the emergence of motor abnormalities, refractory symptoms, and rebound psychosis. The underlying mechanisms are unclear and no approaches exist to prevent or reverse these unwanted effects of antipsychotic treatment. Here we demonstrate that behavioral supersensitivity stems from long-lasting pre, post and perisynaptic plasticity, including insertion of Ca
1000 Sacherschließung
lokal Cocaine/pharmacology [MeSH]
lokal Neuroscience
lokal Nucleus Accumbens/metabolism [MeSH]
lokal Antipsychotic Agents/pharmacology [MeSH]
lokal Receptors, Dopamine D2/metabolism [MeSH]
lokal Immediate Communication
lokal Psychiatric disorders
lokal Receptors, Dopamine D1/metabolism [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-9267-9492|https://frl.publisso.de/adhoc/uri/UGFycmlsbGEtQ2FycmVybywgSmVmZnJleQ==|https://frl.publisso.de/adhoc/uri/UG93ZWxsLCBDb3VydG5leQ==|https://frl.publisso.de/adhoc/uri/QnJhbmR0LCBMYXNzZQ==|https://frl.publisso.de/adhoc/uri/R3V0d2luc2tpLCBTdGVmYW4=|https://frl.publisso.de/adhoc/uri/QW5nZWxpcywgQXJpYW5h|https://frl.publisso.de/adhoc/uri/Q2hhbGhvdWIsIFJlZGEgTS4=|https://frl.publisso.de/adhoc/uri/SmhvdSwgVGhvbWFzIEMu|https://orcid.org/0000-0001-9487-0119|https://orcid.org/0000-0003-3630-0147
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1000 Erstellt am 2023-04-27T10:38:26.389+0200
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1000 Zuletzt bearbeitet 2023-10-20T07:59:02.715+0200
1000 Objekt bearb. Fri Oct 20 07:59:02 CEST 2023
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