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1000 Titel
  • Evaluation of a multiplex PCR screening approach to identify community-acquired bacterial co-infections in COVID-19: a multicenter prospective cohort study of the German competence network of community-acquired pneumonia (CAPNETZ)
1000 Autor/in
  1. Rothe, Kathrin |
  2. Spinner, Christoph D. |
  3. Panning, Marcus |
  4. Pletz, Mathias W. |
  5. Rohde, Gernot |
  6. Rupp, Jan |
  7. Witzenrath, Martin |
  8. Erber, Johanna |
  9. Eberhardt, Frank |
  10. Essig, Andreas |
  11. Schneider, Jochen |
  12. Dreher, M. |
  13. Cornelissen, C |
  14. Knüppel, W. |
  15. Stolz, D. |
  16. Suttorp, N. |
  17. Creutz, P. |
  18. Mikolajewska, A. |
  19. le Claire, A. |
  20. Benzke, M. |
  21. Bauer, T. |
  22. Krieger, D. |
  23. Prediger, M. |
  24. Schmager, S. |
  25. Kolditz, M. |
  26. Schulte-Hubbert, B. |
  27. Langner, S. |
  28. Degen, O. |
  29. Hüfner, A. |
  30. Hoffmann, C. |
  31. Welte, T. |
  32. Freise, J. |
  33. Barten-Neiner, G. |
  34. Nawrocki, M. |
  35. Fuge, I. |
  36. Naim, J. |
  37. Kröner, W. |
  38. Illig, T. |
  39. Klopp, N. |
  40. Kroegel, C. |
  41. Moeser, A. |
  42. Schleenvoigt, B. |
  43. Forstner, C. |
  44. Drömann, D. |
  45. Parschke, P. |
  46. Franzen, K. |
  47. Rupp, J. |
  48. Käding, N. |
  49. Wouters, E. |
  50. Walraven, K. |
  51. Braeken, D. |
  52. Spinner, C. |
  53. Buschmann, H. |
  54. Zaruchas, A. |
  55. Schaberg, T. |
  56. Hering, I. |
  57. Albrich, W. |
  58. Waldeck, F. |
  59. Rassouli, F. |
  60. Baldesberger, S |
  61. Panning, M. |
  62. Wallner, M. |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-10-23
1000 Erschienen in
1000 Quellenangabe
  • 49(6):1299-1306
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s15010-021-01720-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536912/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!Thorough knowledge of the nature and frequency of co-infections is essential to optimize treatment strategies and risk assessment in cases of coronavirus disease 2019 (COVID-19). This study aimed to evaluate the multiplex polymerase chain reaction (PCR) screening approach for community-acquired bacterial pathogens (CABPs) at hospital admission, which could facilitate identification of bacterial co-infections in hospitalized COVID-19 patients.!##!Methods!#!Clinical data and biomaterials from 200 hospitalized COVID-19 patients from the observational cohort of the Competence Network for community-acquired pneumonia (CAPNETZ) prospectively recruited between March 17, 2020, and March 12, 2021 in 12 centers in Germany and Switzerland, were included in this study. Nasopharyngeal swab samples were analyzed on hospital admission using multiplex real-time reverse transcription (RT)-PCR for a broad range of CABPs.!##!Results!#!In total of 200 patients Staphylococcus aureus (27.0%), Haemophilus influenzae (13.5%), Streptococcus pneumoniae (5.5%), Moraxella catarrhalis (2.5%), and Legionella pneumophila (1.5%) were the most frequently detected bacterial pathogens. PCR detection of bacterial pathogens correlated with purulent sputum, and showed no correlation with ICU admission, mortality, and inflammation markers. Although patients who received antimicrobial treatment were more often admitted to the ICU and had a higher mortality rate, PCR pathogen detection was not significantly related to antimicrobial treatment.!##!Conclusion!#!General CABP screening using multiplex PCR with nasopharyngeal swabs may not facilitate prediction or identification of bacterial co-infections in the early phase of COVID-19-related hospitalization. Most patients with positive PCR results appear to be colonized rather than infected at that time, questioning the value of routine antibiotic treatment on admission in COVID-19 patients.
1000 Sacherschließung
lokal Legionella pneumophila [MeSH]
lokal Rapid multiplex PCR diagnostic
gnd 1206347392 COVID-19
lokal Coinfection/epidemiology [MeSH]
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal COVID-19
lokal Multiplex Polymerase Chain Reaction [MeSH]
lokal COVID-19 / SARS-CoV-2
lokal Cohort Studies [MeSH]
lokal Antibiotic stewardship
lokal Pneumonia [MeSH]
lokal Community-acquired co-infection
lokal COVID-19 [MeSH]
lokal Original Paper
lokal Community-Acquired Infections/diagnosis [MeSH]
lokal Coinfection/diagnosis [MeSH]
lokal Bacterial pathogens
lokal SARS-CoV-2 [MeSH]
1000 Liste der Beteiligten
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