In-depth profiling of COVID-19 risk factors and preventive measures in healthcare workers

  1. Wratil, Paul R ORCID logo
  2. Schmacke, Niklas ORCID logo
  3. Osterman, Andreas
  4. Weinberger, Tobias
  5. Rech, Jochen
  6. Karakoc, Burak
  7. Zeilberger, Mira
  8. Steffen, Julius
  9. Mueller, Tonina T.
  10. Spaeth, Patricia M.
  11. Stern, Marcel
  12. Albanese, Manuel
  13. Thun, Hella
  14. Reinbold, Julia
  15. Sandmeyer, Benedikt
  16. Kressirer, Philipp
  17. Grabein, Béatrice
  18. Falkai, Peter
  19. Adorjan, Kristina
  20. Hornung, Veit
  21. Kaderali, Lars
  22. Klein, Matthias
  23. Keppler, Oliver T ORCID logo

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1000 Titel
  • In-depth profiling of COVID-19 risk factors and preventive measures in healthcare workers
1000 Autor/in
  1. Wratil, Paul R |
  2. Schmacke, Niklas |
  3. Osterman, Andreas |
  4. Weinberger, Tobias |
  5. Rech, Jochen |
  6. Karakoc, Burak |
  7. Zeilberger, Mira |
  8. Steffen, Julius |
  9. Mueller, Tonina T. |
  10. Spaeth, Patricia M. |
  11. Stern, Marcel |
  12. Albanese, Manuel |
  13. Thun, Hella |
  14. Reinbold, Julia |
  15. Sandmeyer, Benedikt |
  16. Kressirer, Philipp |
  17. Grabein, Béatrice |
  18. Falkai, Peter |
  19. Adorjan, Kristina |
  20. Hornung, Veit |
  21. Kaderali, Lars |
  22. Klein, Matthias |
  23. Keppler, Oliver T |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-08-11
1000 Erschienen in
1000 Quellenangabe
  • 50(2):381-394
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s15010-021-01672-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354838/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!To determine risk factors for coronavirus disease 2019 (COVID-19) in healthcare workers (HCWs), characterize symptoms, and evaluate preventive measures against SARS-CoV-2 spread in hospitals.!##!Methods!#!In a cross-sectional study conducted between May 27 and August 12, 2020, after the first wave of the COVID-19 pandemic, we obtained serological, epidemiological, occupational as well as COVID-19-related data at a quaternary care, multicenter hospital in Munich, Germany.!##!Results!#!7554 HCWs participated, 2.2% of whom tested positive for anti-SARS-CoV-2 antibodies. Multivariate analysis revealed increased COVID-19 risk for nurses (3.1% seropositivity, 95% CI 2.5-3.9%, p = 0.012), staff working on COVID-19 units (4.6% seropositivity, 95% CI 3.2-6.5%, p = 0.032), males (2.4% seropositivity, 95% CI 1.8-3.2%, p = 0.019), and HCWs reporting high-risk exposures to infected patients (5.5% seropositivity, 95% CI 4.0-7.5%, p = 0.0022) or outside of work (12.0% seropositivity, 95% CI 8.0-17.4%, p < 0.0001). Smoking was a protective factor (1.1% seropositivity, 95% CI 0.7-1.8% p = 0.00018) and the symptom taste disorder was strongly associated with COVID-19 (29.8% seropositivity, 95% CI 24.3-35.8%, p < 0.0001). An unbiased decision tree identified subgroups with different risk profiles. Working from home as a preventive measure did not protect against SARS-CoV-2 infection. A PCR-testing strategy focused on symptoms and high-risk exposures detected all larger COVID-19 outbreaks.!##!Conclusion!#!Awareness of the identified COVID-19 risk factors and successful surveillance strategies are key to protecting HCWs against SARS-CoV-2, especially in settings with limited vaccination capacities or reduced vaccine efficacy.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Pandemics/prevention
lokal Humans [MeSH]
lokal Prevention
lokal Risk Factors [MeSH]
lokal COVID-19
lokal Cross-Sectional Studies [MeSH]
lokal COVID-19 / SARS-CoV-2
lokal Risk factors
lokal Male [MeSH]
lokal COVID-19/prevention
lokal Original Paper
lokal Healthcare workers
lokal COVID-19/epidemiology [MeSH]
lokal SARS-CoV-2 [MeSH]
lokal SARS-CoV-2
lokal Health Personnel [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-0942-0637|https://orcid.org/0000-0002-3998-1139|https://frl.publisso.de/adhoc/uri/T3N0ZXJtYW4sIEFuZHJlYXM=|https://frl.publisso.de/adhoc/uri/V2VpbmJlcmdlciwgVG9iaWFz|https://frl.publisso.de/adhoc/uri/UmVjaCwgSm9jaGVu|https://frl.publisso.de/adhoc/uri/S2FyYWtvYywgQnVyYWs=|https://frl.publisso.de/adhoc/uri/WmVpbGJlcmdlciwgTWlyYQ==|https://frl.publisso.de/adhoc/uri/U3RlZmZlbiwgSnVsaXVz|https://frl.publisso.de/adhoc/uri/TXVlbGxlciwgVG9uaW5hIFQu|https://frl.publisso.de/adhoc/uri/U3BhZXRoLCBQYXRyaWNpYSBNLg==|https://frl.publisso.de/adhoc/uri/U3Rlcm4sIE1hcmNlbA==|https://frl.publisso.de/adhoc/uri/QWxiYW5lc2UsIE1hbnVlbA==|https://frl.publisso.de/adhoc/uri/VGh1biwgSGVsbGE=|https://frl.publisso.de/adhoc/uri/UmVpbmJvbGQsIEp1bGlh|https://frl.publisso.de/adhoc/uri/U2FuZG1leWVyLCBCZW5lZGlrdA==|https://frl.publisso.de/adhoc/uri/S3Jlc3NpcmVyLCBQaGlsaXBw|https://frl.publisso.de/adhoc/uri/R3JhYmVpbiwgQsOpYXRyaWNl|https://frl.publisso.de/adhoc/uri/RmFsa2FpLCBQZXRlcg==|https://frl.publisso.de/adhoc/uri/QWRvcmphbiwgS3Jpc3RpbmE=|https://frl.publisso.de/adhoc/uri/SG9ybnVuZywgVmVpdA==|https://frl.publisso.de/adhoc/uri/S2FkZXJhbGksIExhcnM=|https://frl.publisso.de/adhoc/uri/S2xlaW4sIE1hdHRoaWFz|https://orcid.org/0000-0002-1384-8946
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1000 Erstellt am 2023-04-27T11:43:40.437+0200
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