Simultaneous Brg1 Knockout and MYCN Overexpression in Cerebellar Granule Neuron Precursors Is Insufficient to Drive Tumor Formation but Temporarily Enhances their Proliferation and Delays their Migration

  1. Holdhof, Dörthe ORCID logo
  2. On, Ji Hoon
  3. Schoof, Melanie ORCID logo
  4. Göbel, Carolin
  5. Schüller, Ulrich ORCID logo

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1000 Titel
  • Simultaneous Brg1 Knockout and MYCN Overexpression in Cerebellar Granule Neuron Precursors Is Insufficient to Drive Tumor Formation but Temporarily Enhances their Proliferation and Delays their Migration
1000 Autor/in
  1. Holdhof, Dörthe |
  2. On, Ji Hoon |
  3. Schoof, Melanie |
  4. Göbel, Carolin |
  5. Schüller, Ulrich |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-02
1000 Erschienen in
1000 Quellenangabe
  • 20(3):410-419
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s12311-020-01219-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213679/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Medulloblastoma (MB) is the most common malignant brain tumor in childhood. According to the World Health Organization (WHO) classification of central nervous system (CNS) tumors, this embryonal tumor is divided into a wingless (WNT)-activated, Sonic hedgehog (SHH)-activated, and non-WNT/non-SHH entity. The latter is poorly defined but frequently carries mutations in Brahma-related gene 1 (BRG1) or amplifications of MYCN. Here, we investigated whether a combination of a Brg1 knockout and an overexpression of MYCN in cerebellar granule neuron precursors or multipotent neural stem cells is sufficient to drive brain tumor formation in mice. To this end, we generated Math1-creER
1000 Sacherschließung
lokal Female [MeSH]
lokal Cell Proliferation [MeSH]
lokal Cell Movement/genetics [MeSH]
lokal MYCN
lokal Brain Neoplasms/genetics [MeSH]
lokal Neural Stem Cells/metabolism [MeSH]
lokal Medulloblastoma
lokal N-Myc Proto-Oncogene Protein/genetics [MeSH]
lokal Transcription Factors/genetics [MeSH]
lokal BRG1
lokal Animals [MeSH]
lokal Cerebellum/cytology [MeSH]
lokal Mouse
lokal Mice, Knockout [MeSH]
lokal Immunohistochemistry [MeSH]
lokal Original Article
lokal Nuclear Proteins/genetics [MeSH]
lokal DNA Helicases/genetics [MeSH]
lokal Mice [MeSH]
lokal Basic Helix-Loop-Helix Transcription Factors/genetics [MeSH]
lokal Male [MeSH]
lokal Cytoplasmic Granules/metabolism [MeSH]
lokal Migration deficit
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-4664-3848|https://frl.publisso.de/adhoc/uri/T24sIEppIEhvb24=|https://orcid.org/0000-0002-1373-8130|https://frl.publisso.de/adhoc/uri/R8O2YmVsLCBDYXJvbGlu|https://orcid.org/0000-0002-8731-1121
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  • DeepGreen-ID: 4f56bfa5c43b424e98275b452d48c6d1 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-04-27T12:30:45.437+0200
1000 Erstellt von 322
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1000 Zuletzt bearbeitet 2023-10-20T12:15:56.582+0200
1000 Objekt bearb. Fri Oct 20 12:15:56 CEST 2023
1000 Vgl. frl:6444240
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