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1000 Titel
  • OXTR-Related Markers in Clinical Depression: a Longitudinal Case–Control Psychotherapy Study
1000 Autor/in
  1. Reiner, Iris |
  2. Gimpl, Gerald |
  3. Beutel, Manfred E. |
  4. Bakermans-Kranenburg, Marian J. |
  5. Frieling, Helge |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-11-25
1000 Erschienen in
1000 Quellenangabe
  • 72(4):695-707
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s12031-021-01930-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986708/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • We investigated stability and change of plasma and urinary oxytocin as well as OXTR DNA methylation patterns through psychotherapy. Furthermore, we explore the potential impact of inpatient psychotherapy on oxytocin-related biomarkers and vice versa by differentiating patients who remitted from depression versus non-remitters. Blood and urine samples were taken from 85 premenopausal women (aged 19-52), 43 clinically depressed patients from a psychosomatic inpatient unit, and 42 healthy control subjects matched for age and education at two points of time. Serum and urine oxytocin was measured using standard ELISA, and DNA methylation of the OXTR gene was assessed using bisulfite sequencing at the time of admission (baseline) and at discharge and from controls at matched time points. Oxytocin plasma levels were not associated with depression and were influenced by neither time in healthy controls nor psychotherapy in patients. Non-remitting depressed patients had significantly lower oxytocin urine levels before and after psychotherapy treatment. We found significantly lower exon 1 OTXR methylation in depressed patients over time and these differences were driven by patients remitting due to psychotherapy. A reverse pattern - higher levels of methylation in remitters - was found for exon 2 OXTR DNA methylation. Plasma oxytocin, urinary oxytocin, and OXTR DNA methylation patterns were intrapersonally relatively stable. OXTR-related factors were seemingly unaffected by inpatient psychotherapeutic treatment, but we found significant differences between remitting and non-remitting patients in urinary oxytocin and OXTR DNA methylation. If replicated, this suggests that OXTR-related markers may predict inpatient treatment outcomes of clinically depressed patients.
1000 Sacherschließung
lokal Female [MeSH]
lokal Oxytocin
lokal Adult [MeSH]
lokal Receptors, Oxytocin/genetics [MeSH]
lokal Humans [MeSH]
lokal Psychotherapy
lokal Oxytocin/genetics [MeSH]
lokal OXTR methylation
lokal Middle Aged [MeSH]
lokal Psychotherapy [MeSH]
lokal Receptors, Oxytocin/metabolism [MeSH]
lokal Depression/genetics [MeSH]
lokal Article
lokal Depression
lokal DNA Methylation [MeSH]
lokal Depression/therapy [MeSH]
lokal Young Adult [MeSH]
lokal Case-Control Studies [MeSH]
lokal Oxytocin/metabolism [MeSH]
lokal Biomarkers [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-7393-0335|https://frl.publisso.de/adhoc/uri/R2ltcGwsIEdlcmFsZA==|https://frl.publisso.de/adhoc/uri/QmV1dGVsLCBNYW5mcmVkIEUu|https://frl.publisso.de/adhoc/uri/QmFrZXJtYW5zLUtyYW5lbmJ1cmcsIE1hcmlhbiBKLg==|https://frl.publisso.de/adhoc/uri/RnJpZWxpbmcsIEhlbGdl
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1000 Erstellt am 2023-04-28T10:53:41.975+0200
1000 Erstellt von 322
1000 beschreibt frl:6445638
1000 Zuletzt bearbeitet Fri Oct 20 15:59:14 CEST 2023
1000 Objekt bearb. Fri Oct 20 15:59:14 CEST 2023
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