Extended Coagulation Profiling in Isolated Traumatic Brain Injury: A CENTER-TBI Analysis

  1. Böhm, Julia K.
  2. Schaeben, Victoria
  3. Güting, Helge
  4. Thorn, Sophie
  5. Schöchl, Herbert
  6. Zipperle, Johannes
  7. Grottke, Oliver
  8. Åkerlund, Cecilia
  9. Amrein, Krisztina
  10. Andelic, Nada
  11. Andreassen, Lasse
  12. Anke, Audny
  13. Antoni, Anna
  14. Audibert, Gérard
  15. Azouvi, Philippe
  16. Azzolini, Maria Luisa
  17. Bartels, Ronald
  18. Barzó, Pál
  19. Beauvais, Romuald
  20. Beer, Ronny
  21. Bellander, Bo-Michael
  22. Belli, Antonio
  23. Benali, Habib
  24. Berardino, Maurizio
  25. Beretta, Luigi
  26. Blaabjerg, Morten
  27. Bragge, Peter
  28. Brazinova, Alexandra
  29. Brinck, Vibeke
  30. Brooker, Joanne
  31. Brorsson, Camilla
  32. Buki, Andras
  33. Bullinger, Monika
  34. Cabeleira, Manuel
  35. Caccioppola, Alessio
  36. Calappi, Emiliana
  37. Calvi, Maria Rosa
  38. Cameron, Peter
  39. Lozano, Guillermo Carbayo
  40. Carbonara, Marco
  41. Cavallo, Simona
  42. Chevallard, Giorgio
  43. Chieregato, Arturo
  44. Citerio, Giuseppe
  45. Ceyisakar, Iris
  46. Clusmann, Hans
  47. Coburn, Mark
  48. Coles, Jonathan
  49. Cooper, Jamie D.
  50. Correia, Marta
  51. Čović, Amra
  52. Curry, Nicola
  53. Czeiter, Endre
  54. Czosnyka, Marek
  55. Dahyot-Fizelier, Claire
  56. Dark, Paul
  57. Dawes, Helen
  58. De Keyser, Véronique
  59. Degos, Vincent
  60. Corte, Francesco Della
  61. Boogert, Hugo den
  62. Depreitere, Bart
  63. Đilvesi, Đula
  64. Dixit, Abhishek
  65. Donoghue, Emma
  66. Dreier, Jens
  67. Dulière, Guy-Loup
  68. Ercole, Ari
  69. Esser, Patrick
  70. Ezer, Erzsébet
  71. Fabricius, Martin
  72. Feigin, Valery L.
  73. Foks, Kelly
  74. Frisvold, Shirin
  75. Furmanov, Alex
  76. Gagliardo, Pablo
  77. Galanaud, Damien
  78. Gantner, Dashiell
  79. Gao, Guoyi
  80. George, Pradeep
  81. Ghuysen, Alexandre
  82. Giga, Lelde
  83. Glocker, Ben
  84. Golubovic, Jagoš
  85. Gomez, Pedro A.
  86. Gratz, Johannes
  87. Gravesteijn, Benjamin
  88. Grossi, Francesca
  89. Gruen, Russell L.
  90. Gupta, Deepak
  91. Haagsma, Juanita A.
  92. Haitsma, Iain
  93. Helbok, Raimund
  94. Helseth, Eirik
  95. Horton, Lindsay
  96. Huijben, Jilske
  97. Hutchinson, Peter J.
  98. Jacobs, Bram
  99. Jankowski, Stefan
  100. Jarrett, Mike
  101. Jiang, Ji-yao
  102. Johnson, Faye
  103. Jones, Kelly
  104. Karan, Mladen
  105. Kolias, Angelos G.
  106. Kompanje, Erwin
  107. Kondziella, Daniel
  108. Koraropoulos, Evgenios
  109. Koskinen, Lars-Owe
  110. Kovács, Noémi
  111. Kowark, Ana
  112. Lagares, Alfonso
  113. Lanyon, Linda
  114. Laureys, Steven
  115. Lecky, Fiona
  116. Ledoux, Didier
  117. Lefering, Rolf
  118. Legrand, Valerie
  119. Lejeune, Aurelie
  120. Levi, Leon
  121. Lightfoot, Roger
  122. Lingsma, Hester
  123. Maas, Andrew I. R.
  124. Castaño-León, Ana M.
  125. Maegele, Marc
  126. Majdan, Marek
  127. Manara, Alex
  128. Manley, Geoffrey
  129. Martino, Costanza
  130. Maréchal, Hugues
  131. Mattern, Julia
  132. McMahon, Catherine
  133. Melegh, Béla
  134. Menon, David
  135. Menovsky, Tomas
  136. Mikolic, Ana
  137. Misset, Benoit
  138. Muraleedharan, Visakh
  139. Murray, Lynnette
  140. Negru, Ancuta
  141. Nelson, David
  142. Newcombe, Virginia
  143. Nieboer, Daan
  144. Nyirádi, József
  145. Olubukola, Otesile
  146. Oresic, Matej
  147. Ortolano, Fabrizio
  148. Palotie, Aarno
  149. Parizel, Paul M.
  150. Payen, Jean-François
  151. Perera, Natascha
  152. Perlbarg, Vincent
  153. Persona, Paolo
  154. Peul, Wilco
  155. Piippo-Karjalainen, Anna
  156. Pirinen, Matti
  157. Ples, Horia
  158. Polinder, Suzanne
  159. Pomposo, Inigo
  160. Posti, Jussi P.
  161. Puybasset, Louis
  162. Radoi, Andreea
  163. Ragauskas, Arminas
  164. Raj, Rahul
  165. Rambadagalla, Malinka
  166. Rhodes, Jonathan
  167. Richardson, Sylvia
  168. Richter, Sophie
  169. Ripatti, Samuli
  170. Rocka, Saulius
  171. Roe, Cecilie
  172. Roise, Olav
  173. Rosand, Jonathan
  174. Rosenfeld, Jeffrey V.
  175. Rosenlund, Christina
  176. Rosenthal, Guy
  177. Rossaint, Rolf
  178. Rossi, Sandra
  179. Rueckert, Daniel
  180. Rusnák, Martin
  181. Sahuquillo, Juan
  182. Sakowitz, Oliver
  183. Sanchez-Porras, Renan
  184. Sandor, Janos
  185. Schäfer, Nadine
  186. Schmidt, Silke
  187. Schoechl, Herbert
  188. Schoonman, Guus
  189. Schou, Rico Frederik
  190. Schwendenwein, Elisabeth
  191. Sewalt, Charlie
  192. Skandsen, Toril
  193. Smielewski, Peter
  194. Sorinola, Abayomi
  195. Stamatakis, Emmanuel
  196. Stanworth, Simon
  197. Stevens, Robert
  198. Stewart, William
  199. Steyerberg, Ewout W.
  200. Stocchetti, Nino
  201. Sundström, Nina
  202. Synnot, Anneliese
  203. Takala, Riikka
  204. Tamás, Viktória
  205. Tamosuitis, Tomas
  206. Taylor, Mark Steven
  207. Ao, Braden Te
  208. Tenovuo, Olli
  209. Theadom, Alice
  210. Thomas, Matt
  211. Tibboel, Dick
  212. Timmers, Marjolein
  213. Tolias, Christos
  214. Trapani, Tony
  215. Tudora, Cristina Maria
  216. Unterberg, Andreas
  217. Vajkoczy, Peter
  218. Vallance, Shirley
  219. Valeinis, Egils
  220. Vámos, Zoltán
  221. van der Jagt, Mathieu
  222. Van der Steen, Gregory
  223. Naalt, Joukje van der
  224. van Dijck, Jeroen T. J. M.
  225. van Essen, Thomas A.
  226. Van Hecke, Wim
  227. van Heugten, Caroline
  228. Van Praag, Dominique
  229. Vyvere, Thijs Vande
  230. van Wijk, Roel P. J.
  231. Vargiolu, Alessia
  232. Vega, Emmanuel
  233. Velt, Kimberley
  234. Verheyden, Jan
  235. Vespa, Paul M.
  236. Vik, Anne
  237. Vilcinis, Rimantas
  238. Volovici, Victor
  239. von Steinbüchel, Nicole
  240. Voormolen, Daphne
  241. Vulekovic, Petar
  242. Wang, Kevin K. W.
  243. Wiegers, Eveline
  244. Williams, Guy
  245. Wilson, Lindsay
  246. Winzeck, Stefan
  247. Wolf, Stefan
  248. Yang, Zhihui
  249. Ylén, Peter
  250. Younsi, Alexander
  251. Zeiler, Frederick A.
  252. Zelinkova, Veronika
  253. Ziverte, Agate
  254. Zoerle, Tommaso

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1000 Titel
  • Extended Coagulation Profiling in Isolated Traumatic Brain Injury: A CENTER-TBI Analysis
1000 Autor/in
  1. Böhm, Julia K. |
  2. Schaeben, Victoria |
  3. Güting, Helge |
  4. Thorn, Sophie |
  5. Schöchl, Herbert |
  6. Zipperle, Johannes |
  7. Grottke, Oliver |
  8. Åkerlund, Cecilia |
  9. Amrein, Krisztina |
  10. Andelic, Nada |
  11. Andreassen, Lasse |
  12. Anke, Audny |
  13. Antoni, Anna |
  14. Audibert, Gérard |
  15. Azouvi, Philippe |
  16. Azzolini, Maria Luisa |
  17. Bartels, Ronald |
  18. Barzó, Pál |
  19. Beauvais, Romuald |
  20. Beer, Ronny |
  21. Bellander, Bo-Michael |
  22. Belli, Antonio |
  23. Benali, Habib |
  24. Berardino, Maurizio |
  25. Beretta, Luigi |
  26. Blaabjerg, Morten |
  27. Bragge, Peter |
  28. Brazinova, Alexandra |
  29. Brinck, Vibeke |
  30. Brooker, Joanne |
  31. Brorsson, Camilla |
  32. Buki, Andras |
  33. Bullinger, Monika |
  34. Cabeleira, Manuel |
  35. Caccioppola, Alessio |
  36. Calappi, Emiliana |
  37. Calvi, Maria Rosa |
  38. Cameron, Peter |
  39. Lozano, Guillermo Carbayo |
  40. Carbonara, Marco |
  41. Cavallo, Simona |
  42. Chevallard, Giorgio |
  43. Chieregato, Arturo |
  44. Citerio, Giuseppe |
  45. Ceyisakar, Iris |
  46. Clusmann, Hans |
  47. Coburn, Mark |
  48. Coles, Jonathan |
  49. Cooper, Jamie D. |
  50. Correia, Marta |
  51. Čović, Amra |
  52. Curry, Nicola |
  53. Czeiter, Endre |
  54. Czosnyka, Marek |
  55. Dahyot-Fizelier, Claire |
  56. Dark, Paul |
  57. Dawes, Helen |
  58. De Keyser, Véronique |
  59. Degos, Vincent |
  60. Corte, Francesco Della |
  61. Boogert, Hugo den |
  62. Depreitere, Bart |
  63. Đilvesi, Đula |
  64. Dixit, Abhishek |
  65. Donoghue, Emma |
  66. Dreier, Jens |
  67. Dulière, Guy-Loup |
  68. Ercole, Ari |
  69. Esser, Patrick |
  70. Ezer, Erzsébet |
  71. Fabricius, Martin |
  72. Feigin, Valery L. |
  73. Foks, Kelly |
  74. Frisvold, Shirin |
  75. Furmanov, Alex |
  76. Gagliardo, Pablo |
  77. Galanaud, Damien |
  78. Gantner, Dashiell |
  79. Gao, Guoyi |
  80. George, Pradeep |
  81. Ghuysen, Alexandre |
  82. Giga, Lelde |
  83. Glocker, Ben |
  84. Golubovic, Jagoš |
  85. Gomez, Pedro A. |
  86. Gratz, Johannes |
  87. Gravesteijn, Benjamin |
  88. Grossi, Francesca |
  89. Gruen, Russell L. |
  90. Gupta, Deepak |
  91. Haagsma, Juanita A. |
  92. Haitsma, Iain |
  93. Helbok, Raimund |
  94. Helseth, Eirik |
  95. Horton, Lindsay |
  96. Huijben, Jilske |
  97. Hutchinson, Peter J. |
  98. Jacobs, Bram |
  99. Jankowski, Stefan |
  100. Jarrett, Mike |
  101. Jiang, Ji-yao |
  102. Johnson, Faye |
  103. Jones, Kelly |
  104. Karan, Mladen |
  105. Kolias, Angelos G. |
  106. Kompanje, Erwin |
  107. Kondziella, Daniel |
  108. Koraropoulos, Evgenios |
  109. Koskinen, Lars-Owe |
  110. Kovács, Noémi |
  111. Kowark, Ana |
  112. Lagares, Alfonso |
  113. Lanyon, Linda |
  114. Laureys, Steven |
  115. Lecky, Fiona |
  116. Ledoux, Didier |
  117. Lefering, Rolf |
  118. Legrand, Valerie |
  119. Lejeune, Aurelie |
  120. Levi, Leon |
  121. Lightfoot, Roger |
  122. Lingsma, Hester |
  123. Maas, Andrew I. R. |
  124. Castaño-León, Ana M. |
  125. Maegele, Marc |
  126. Majdan, Marek |
  127. Manara, Alex |
  128. Manley, Geoffrey |
  129. Martino, Costanza |
  130. Maréchal, Hugues |
  131. Mattern, Julia |
  132. McMahon, Catherine |
  133. Melegh, Béla |
  134. Menon, David |
  135. Menovsky, Tomas |
  136. Mikolic, Ana |
  137. Misset, Benoit |
  138. Muraleedharan, Visakh |
  139. Murray, Lynnette |
  140. Negru, Ancuta |
  141. Nelson, David |
  142. Newcombe, Virginia |
  143. Nieboer, Daan |
  144. Nyirádi, József |
  145. Olubukola, Otesile |
  146. Oresic, Matej |
  147. Ortolano, Fabrizio |
  148. Palotie, Aarno |
  149. Parizel, Paul M. |
  150. Payen, Jean-François |
  151. Perera, Natascha |
  152. Perlbarg, Vincent |
  153. Persona, Paolo |
  154. Peul, Wilco |
  155. Piippo-Karjalainen, Anna |
  156. Pirinen, Matti |
  157. Ples, Horia |
  158. Polinder, Suzanne |
  159. Pomposo, Inigo |
  160. Posti, Jussi P. |
  161. Puybasset, Louis |
  162. Radoi, Andreea |
  163. Ragauskas, Arminas |
  164. Raj, Rahul |
  165. Rambadagalla, Malinka |
  166. Rhodes, Jonathan |
  167. Richardson, Sylvia |
  168. Richter, Sophie |
  169. Ripatti, Samuli |
  170. Rocka, Saulius |
  171. Roe, Cecilie |
  172. Roise, Olav |
  173. Rosand, Jonathan |
  174. Rosenfeld, Jeffrey V. |
  175. Rosenlund, Christina |
  176. Rosenthal, Guy |
  177. Rossaint, Rolf |
  178. Rossi, Sandra |
  179. Rueckert, Daniel |
  180. Rusnák, Martin |
  181. Sahuquillo, Juan |
  182. Sakowitz, Oliver |
  183. Sanchez-Porras, Renan |
  184. Sandor, Janos |
  185. Schäfer, Nadine |
  186. Schmidt, Silke |
  187. Schoechl, Herbert |
  188. Schoonman, Guus |
  189. Schou, Rico Frederik |
  190. Schwendenwein, Elisabeth |
  191. Sewalt, Charlie |
  192. Skandsen, Toril |
  193. Smielewski, Peter |
  194. Sorinola, Abayomi |
  195. Stamatakis, Emmanuel |
  196. Stanworth, Simon |
  197. Stevens, Robert |
  198. Stewart, William |
  199. Steyerberg, Ewout W. |
  200. Stocchetti, Nino |
  201. Sundström, Nina |
  202. Synnot, Anneliese |
  203. Takala, Riikka |
  204. Tamás, Viktória |
  205. Tamosuitis, Tomas |
  206. Taylor, Mark Steven |
  207. Ao, Braden Te |
  208. Tenovuo, Olli |
  209. Theadom, Alice |
  210. Thomas, Matt |
  211. Tibboel, Dick |
  212. Timmers, Marjolein |
  213. Tolias, Christos |
  214. Trapani, Tony |
  215. Tudora, Cristina Maria |
  216. Unterberg, Andreas |
  217. Vajkoczy, Peter |
  218. Vallance, Shirley |
  219. Valeinis, Egils |
  220. Vámos, Zoltán |
  221. van der Jagt, Mathieu |
  222. Van der Steen, Gregory |
  223. Naalt, Joukje van der |
  224. van Dijck, Jeroen T. J. M. |
  225. van Essen, Thomas A. |
  226. Van Hecke, Wim |
  227. van Heugten, Caroline |
  228. Van Praag, Dominique |
  229. Vyvere, Thijs Vande |
  230. van Wijk, Roel P. J. |
  231. Vargiolu, Alessia |
  232. Vega, Emmanuel |
  233. Velt, Kimberley |
  234. Verheyden, Jan |
  235. Vespa, Paul M. |
  236. Vik, Anne |
  237. Vilcinis, Rimantas |
  238. Volovici, Victor |
  239. von Steinbüchel, Nicole |
  240. Voormolen, Daphne |
  241. Vulekovic, Petar |
  242. Wang, Kevin K. W. |
  243. Wiegers, Eveline |
  244. Williams, Guy |
  245. Wilson, Lindsay |
  246. Winzeck, Stefan |
  247. Wolf, Stefan |
  248. Yang, Zhihui |
  249. Ylén, Peter |
  250. Younsi, Alexander |
  251. Zeiler, Frederick A. |
  252. Zelinkova, Veronika |
  253. Ziverte, Agate |
  254. Zoerle, Tommaso |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-16
1000 Erschienen in
1000 Quellenangabe
  • 36(3):927-941
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s12028-021-01400-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110502/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Trauma-induced coagulopathy in traumatic brain injury (TBI) remains associated with high rates of complications, unfavorable outcomes, and mortality. The underlying mechanisms are largely unknown. Embedded in the prospective multinational Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, coagulation profiles beyond standard conventional coagulation assays were assessed in patients with isolated TBI within the very early hours of injury.!##!Methods!#!Results from blood samples (citrate/EDTA) obtained on hospital admission were matched with clinical and routine laboratory data of patients with TBI captured in the CENTER-TBI central database. To minimize confounding factors, patients with strictly isolated TBI (iTBI) (n = 88) were selected and stratified for coagulopathy by routine international normalized ratio (INR): (1) INR < 1.2 and (2) INR ≥ 1.2. An INR > 1.2 has been well adopted over time as a threshold to define trauma-related coagulopathy in general trauma populations. The following parameters were evaluated: quick's value, activated partial thromboplastin time, fibrinogen, thrombin time, antithrombin, coagulation factor activity of factors V, VIII, IX, and XIII, protein C and S, plasminogen, D-dimer, fibrinolysis-regulating parameters (thrombin activatable fibrinolysis inhibitor, plasminogen activator inhibitor 1, antiplasmin), thrombin generation, and fibrin monomers.!##!Results!#!Patients with iTBI with INR ≥ 1.2 (n = 16) had a high incidence of progressive intracranial hemorrhage associated with increased mortality and unfavorable outcome compared with patients with INR < 1.2 (n = 72). Activity of coagulation factors V, VIII, IX, and XIII dropped on average by 15-20% between the groups whereas protein C and S levels dropped by 20%. With an elevated INR, thrombin generation decreased, as reflected by lower peak height and endogenous thrombin potential (ETP), whereas the amount of fibrin monomers increased. Plasminogen activity significantly decreased from 89% in patients with INR < 1.2 to 76% in patients with INR ≥ 1.2. Moreover, D-dimer levels significantly increased from a mean of 943 mg/L in patients with INR < 1.2 to 1,301 mg/L in patients with INR ≥ 1.2.!##!Conclusions!#!This more in-depth analysis beyond routine conventional coagulation assays suggests a counterbalanced regulation of coagulation and fibrinolysis in patients with iTBI with hemostatic abnormalities. We observed distinct patterns involving key pathways of the highly complex and dynamic coagulation system that offer windows of opportunity for further research. Whether the changes observed on factor levels may be relevant and explain the worse outcome or the more severe brain injuries by themselves remains speculative.
1000 Sacherschließung
lokal Traumatic brain injury
lokal CENTER-TBI
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal Fibrin monomers
lokal Progressive intracranial hemorrhage
lokal Original Work
lokal Thrombin [MeSH]
lokal Coagulopathy
lokal Plasminogen [MeSH]
lokal Blood Coagulation Disorders [MeSH]
lokal Brain Injuries, Traumatic/epidemiology [MeSH]
lokal Thrombin generation
lokal Protein C [MeSH]
1000 Liste der Beteiligten
  1. 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1000 Hinweis
  • DeepGreen-ID: b44bede4b1b9431fa8e2ed8fd51fd2cc ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Dateien
1000 Objektart article
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1000 @id frl:6445644.rdf
1000 Erstellt am 2023-04-28T10:54:44.174+0200
1000 Erstellt von 322
1000 beschreibt frl:6445644
1000 Zuletzt bearbeitet 2023-10-20T16:00:06.762+0200
1000 Objekt bearb. Fri Oct 20 16:00:06 CEST 2023
1000 Vgl. frl:6445644
1000 Oai Id
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