Tumor cell PD-L1 expression is a strong predictor of unfavorable prognosis in immune checkpoint therapy-naive clear cell renal cell cancer

  1. Möller, Katharina
  2. Fraune, Christoph
  3. Blessin, Niclas C.
  4. Lennartz, Maximilian
  5. Kluth, Martina
  6. Hube-Magg, Claudia
  7. Lindhorst, Linnea
  8. Dahlem, Roland
  9. Fisch, Margit
  10. Eichenauer, Till
  11. Riechardt, Silke
  12. Simon, Ronald ORCID logo
  13. Sauter, Guido
  14. Büscheck, Franziska
  15. Höppner, Wolfgang
  16. Matthies, Cord
  17. Doh, Ousman
  18. Krech, Till
  19. Marx, Andreas H.
  20. Zecha, Henrik
  21. Rink, Michael
  22. Steurer, Stefan
  23. Clauditz, Till S.

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1000 Titel
  • Tumor cell PD-L1 expression is a strong predictor of unfavorable prognosis in immune checkpoint therapy-naive clear cell renal cell cancer
1000 Autor/in
  1. Möller, Katharina |
  2. Fraune, Christoph |
  3. Blessin, Niclas C. |
  4. Lennartz, Maximilian |
  5. Kluth, Martina |
  6. Hube-Magg, Claudia |
  7. Lindhorst, Linnea |
  8. Dahlem, Roland |
  9. Fisch, Margit |
  10. Eichenauer, Till |
  11. Riechardt, Silke |
  12. Simon, Ronald |
  13. Sauter, Guido |
  14. Büscheck, Franziska |
  15. Höppner, Wolfgang |
  16. Matthies, Cord |
  17. Doh, Ousman |
  18. Krech, Till |
  19. Marx, Andreas H. |
  20. Zecha, Henrik |
  21. Rink, Michael |
  22. Steurer, Stefan |
  23. Clauditz, Till S. |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-01
1000 Erschienen in
1000 Quellenangabe
  • 53(12):2493-2503
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11255-021-02841-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599390/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!PD-L1 expression predicts response to immune checkpoint inhibitors in renal cell carcinomas (RCC), but has also been suggested to be linked to poor patient outcome.!##!Methods!#!We analyzed PD-L1 in > 1400 RCC in a tissue microarray format by immunohistochemistry. Results were compared with histological tumor type, parameters of cancer aggressiveness, and intratumoral CD8!##!Result!#!At a cut-off level of 5% PD-L1 positive tumor cells, PD-L1 positivity was seen in 6.3% of 633 clear cell RCC (ccRCC), 18.2% of 165 papillary RCC, 18.8% of 64 chromophobe RCC, and 41.7% of 103 oncocytomas. In ccRCC, PD-L1 positivity was significantly linked to high ISUP (p < 0.0001), Fuhrman (p < 0.0001), Thoenes grade (p < 0.0001), distant metastasis (p = 0.0042), short recurrence-free (p < 0.0001), and overall survival (p = 0.0002). Intratumoral CD8!##!Conclusions!#!These data suggest that PD-L1 expression in highly immunogenic RCCs facilitates immune evasion and contributes to cancer aggressiveness.
1000 Sacherschließung
lokal Female [MeSH]
lokal Aged, 80 and over [MeSH]
lokal Neoplasm Grading [MeSH]
lokal PD-L1
lokal Aged [MeSH]
lokal UROLOGY - Original Paper
lokal Humans [MeSH]
lokal Kidney Neoplasms/metabolism [MeSH]
lokal Kidney Neoplasms/pathology [MeSH]
lokal Middle Aged [MeSH]
lokal Prognosis
lokal B7-H1 Antigen/metabolism [MeSH]
lokal Immune Checkpoint Inhibitors/therapeutic use [MeSH]
lokal Carcinoma, Renal Cell/metabolism [MeSH]
lokal Kidney Neoplasms/drug therapy [MeSH]
lokal Immune checkpoint therapy
lokal Carcinoma, Renal Cell/drug therapy [MeSH]
lokal Male [MeSH]
lokal Biomarkers, Tumor/metabolism [MeSH]
lokal Renal cell carcinoma
lokal Germany [MeSH]
lokal Prognosis [MeSH]
lokal Carcinoma, Renal Cell/pathology [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2023-04-28T11:37:11.079+0200
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1000 Zuletzt bearbeitet 2023-10-20T17:08:53.097+0200
1000 Objekt bearb. Fri Oct 20 17:08:53 CEST 2023
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