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1000 Titel
  • Elevated baseline C-reactive protein levels predict poor progression-free survival in sporadic vestibular schwannoma
1000 Autor/in
  1. Wach, Johannes |
  2. Güresir, Ági |
  3. Borger, Valeri |
  4. Schuss, Patrick |
  5. Becker, Albert |
  6. Coch, Christoph |
  7. Schmitz, Marie-Therese |
  8. Hölzel, Michael |
  9. Toma, Marieta |
  10. Herrlinger, Ulrich |
  11. Vatter, Hartmut |
  12. Güresir, Erdem |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-09
1000 Erschienen in
1000 Quellenangabe
  • 156(2):365-375
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11060-021-03918-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816751/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Recent investigations showed emerging evidence of the role of inflammation in the growth of sporadic vestibular schwannoma (VS). The present retrospective study investigated the impact of systemic inflammation on tumor progression using serum C-reactive protein (CRP) levels in a series of 87 surgically treated sporadic VS patients.!##!Methods!#!The optimal cut-off value for CRP was defined as 3.14 mg/dl according to the receiver operating characteristic curve (AUC: 0.70, 95% CI 0.47-0.92). Patient cohort was dichotomized into normal (n = 66; < 3.14 mg/dl) and high baseline (n = 21; ≥ 3.14 mg/dl) CRP groups.!##!Results!#!No significant differences in age, sex, comorbidities influencing the systemic inflammatory state, Karnofsky performance status (KPS), tumor size, extent of resection, or MIB-1 index were identified between the two groups defined by the baseline CRP levels. Univariable analysis demonstrated that a high CRP level (≥ 3.14 mg/dl) is significantly associated with a shortened progression-free survival (PFS) (hazard ratio (HR): 6.05, 95% CI 1.15-31.95, p = 0.03). Multivariable Cox regression analysis considering age, extent of resection, KPS, tumor size, and baseline CRP confirmed that an elevated CRP level (≥ 3.14 mg/dl) is an independent predictor of shortened PFS (HR: 7.20, 95% CI 1.08-48.14, p = 0.04).!##!Conclusions!#!The baseline CRP level thus serves as an independent predictor of PFS. Further investigations of the role of inflammation and tumor inflammatory microenvironment in the prediction of prognosis in sporadic VS are needed.
1000 Sacherschließung
lokal Vestibular schwannoma
lokal Humans [MeSH]
lokal Inflammation
lokal Inflammation [MeSH]
lokal Progression-Free Survival [MeSH]
lokal Progression
lokal Clinical Study
lokal Retrospective Studies [MeSH]
lokal Neuroma, Acoustic/pathology [MeSH]
lokal C-reactive protein
lokal C-Reactive Protein/metabolism [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-4680-0412|https://frl.publisso.de/adhoc/uri/R8O8cmVzaXIsIMOBZ2k=|https://frl.publisso.de/adhoc/uri/Qm9yZ2VyLCBWYWxlcmk=|https://frl.publisso.de/adhoc/uri/U2NodXNzLCBQYXRyaWNr|https://frl.publisso.de/adhoc/uri/QmVja2VyLCBBbGJlcnQ=|https://frl.publisso.de/adhoc/uri/Q29jaCwgQ2hyaXN0b3Bo|https://frl.publisso.de/adhoc/uri/U2NobWl0eiwgTWFyaWUtVGhlcmVzZQ==|https://frl.publisso.de/adhoc/uri/SMO2bHplbCwgTWljaGFlbA==|https://frl.publisso.de/adhoc/uri/VG9tYSwgTWFyaWV0YQ==|https://frl.publisso.de/adhoc/uri/SGVycmxpbmdlciwgVWxyaWNo|https://frl.publisso.de/adhoc/uri/VmF0dGVyLCBIYXJ0bXV0|https://frl.publisso.de/adhoc/uri/R8O8cmVzaXIsIEVyZGVt
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1000 Erstellt am 2023-04-28T11:47:45.019+0200
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