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1000 Titel
  • The Innate Immune Response Characterizes Posterior Reversible Encephalopathy Syndrome
1000 Autor/in
  1. Nelke, Christopher |
  2. Schulte-Mecklenbeck, Andreas |
  3. Pawlitzki, Marc |
  4. Rolfes, Leoni |
  5. Räuber, Saskia |
  6. Gross, Catharina C. |
  7. Minnerup, Jens |
  8. Meuth, Sven G. |
  9. Wiendl, Heinz |
  10. Ruck, Tobias |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-12
1000 Erschienen in
1000 Quellenangabe
  • 41(6):1229-1240
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s10875-021-01033-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310851/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • While posterior reversible encephalopathy syndrome (PRES) is often characterized by an inflammatory cerebrospinal-fluid (CSF) profile, knowledge of immune cell patterns in PRES is lacking. Thus, we retrospectively characterized CSF and peripheral blood (PB) from 15 PRES patients, which we analyzed by multidimensional flow cytometry (FC). Results were compared to 72 controls, as well as to 9 patients with progressive multifocal leukoencephalopathy (PML, as a relevant differential diagnosis) and 15 multiple sclerosis patients (MS, as a classical neuroinflammatory disorder), respectively. Total protein level in CSF from PRES patients was elevated compared to that in controls, but not to MS and PML. In-depth FC analysis revealed no differences for adaptive immune cells (B cells, plasma cells, CD4
1000 Sacherschließung
lokal Female [MeSH]
lokal Leukoencephalopathy, Progressive Multifocal/immunology [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Monocytes/immunology [MeSH]
lokal Retrospective Studies [MeSH]
lokal posterior reversible encephalopathy syndrome
lokal Middle Aged [MeSH]
lokal Leukoencephalopathy, Progressive Multifocal/diagnosis [MeSH]
lokal Posterior Leukoencephalopathy Syndrome/immunology [MeSH]
lokal Original Article
lokal Lipopolysaccharide Receptors/immunology [MeSH]
lokal CD4-Positive T-Lymphocytes/immunology [MeSH]
lokal Receptors, IgG/immunology [MeSH]
lokal Immunity, Innate/immunology [MeSH]
lokal Male [MeSH]
lokal flow cytometry
lokal Adaptive Immunity/immunology [MeSH]
lokal Posterior Leukoencephalopathy Syndrome/diagnosis [MeSH]
lokal immune cells
lokal CD8-Positive T-Lymphocytes/immunology [MeSH]
lokal PRES
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-6048-7143|https://frl.publisso.de/adhoc/uri/U2NodWx0ZS1NZWNrbGVuYmVjaywgQW5kcmVhcw==|https://frl.publisso.de/adhoc/uri/UGF3bGl0emtpLCBNYXJj|https://frl.publisso.de/adhoc/uri/Um9sZmVzLCBMZW9uaQ==|https://frl.publisso.de/adhoc/uri/UsOkdWJlciwgU2Fza2lh|https://frl.publisso.de/adhoc/uri/R3Jvc3MsIENhdGhhcmluYSBDLg==|https://frl.publisso.de/adhoc/uri/TWlubmVydXAsIEplbnM=|https://frl.publisso.de/adhoc/uri/TWV1dGgsIFN2ZW4gRy4=|https://frl.publisso.de/adhoc/uri/V2llbmRsLCBIZWlueg==|https://frl.publisso.de/adhoc/uri/UnVjaywgVG9iaWFz
1000 Hinweis
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1000 Erstellt am 2023-04-28T12:00:49.219+0200
1000 Erstellt von 322
1000 beschreibt frl:6446041
1000 Zuletzt bearbeitet Fri Oct 20 17:26:45 CEST 2023
1000 Objekt bearb. Fri Oct 20 17:26:45 CEST 2023
1000 Vgl. frl:6446041
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  1. oai:frl.publisso.de:frl:6446041 |
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