Download
s10661-021-09254-0.pdf 897,50KB
WeightNameValue
1000 Titel
  • Implementation of mercury biomonitoring in German adults using dried blood spot sampling in combination with direct mercury analysis
1000 Autor/in
  1. Schweizer, Ann-Kathrin |
  2. Kabesch, Michael |
  3. Quartucci, Caroline |
  4. Bose-O’Reilly, Stephan |
  5. Rakete, Stefan |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-10
1000 Erschienen in
1000 Quellenangabe
  • 193(8):488
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s10661-021-09254-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272700/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Venous blood is a preferred matrix for the determination of total mercury (Hg) in human biomonitoring but has some drawbacks such as the requirement for an uninterrupted cold chain for transport and storage and the need of medical personnel for sample collection. Therefore, we tested and implemented a simpler and less expensive method for measuring Hg in human blood using dried blood spots (DBS). For method development, we investigated the influence of different storage conditions (temperature, storage vessel, time) on DBS samples. For method validation, we compared DBS and venous blood and investigated whether DBS sampling is suitable for measuring Hg in the general population in countries with low Hg exposure such as Germany. Based on our results, we found that pre-cleaned glass tubes were most suitable for storage of DBS samples, as this allowed the samples to remain stable for at least 4 weeks even at high temperatures (40 °C). When comparing venous blood and DBS, a very good correlation (r = 0.95, p < 0.01, Spearman-Rho) and high precision of DBS (mean relative standard deviation 8.2% vs. 7.2% in venous blood samples) were observed. Comparing the recoveries of both matrices in different concentration ranges, the variation of the recoveries decreases with increasing Hg concentration. The mean recoveries also decreased with increasing Hg concentration. Overall, we found comparable results for DBS and venous blood using direct Hg analysis. Furthermore, we demonstrated that DBS are suitable for Hg biomonitoring in the general population in Germany and improved the storage conditions for the DBS.
1000 Sacherschließung
lokal Mercury [MeSH]
lokal Article
lokal Biomonitoring
lokal Biological Monitoring [MeSH]
lokal Mercury
lokal Microsampling
lokal Adult [MeSH]
lokal Germany [MeSH]
lokal Humans [MeSH]
lokal Dried Blood Spot Testing [MeSH]
lokal Environmental Monitoring [MeSH]
lokal Dried blood spots
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2Nod2VpemVyLCBBbm4tS2F0aHJpbg==|https://frl.publisso.de/adhoc/uri/S2FiZXNjaCwgTWljaGFlbA==|https://frl.publisso.de/adhoc/uri/UXVhcnR1Y2NpLCBDYXJvbGluZQ==|https://frl.publisso.de/adhoc/uri/Qm9zZS1P4oCZUmVpbGx5LCBTdGVwaGFu|https://orcid.org/0000-0002-4851-513X
1000 Hinweis
  • DeepGreen-ID: c4c85a701e974056aa27fe3ee65ec11c ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6446105.rdf
1000 Erstellt am 2023-04-28T12:12:24.534+0200
1000 Erstellt von 322
1000 beschreibt frl:6446105
1000 Zuletzt bearbeitet 2023-10-20T17:33:43.464+0200
1000 Objekt bearb. Fri Oct 20 17:33:43 CEST 2023
1000 Vgl. frl:6446105
1000 Oai Id
  1. oai:frl.publisso.de:frl:6446105 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source