The transplant cohort of the German center for infection research (DZIF Tx-Cohort): study design and baseline characteristics

  1. Karch, André
  2. Schindler, Daniela
  3. Kühn-Steven, Andrea
  4. Blaser, Rainer
  5. Kuhn, Klaus A.
  6. Sandmann, Lisa
  7. Sommerer, Claudia
  8. Guba, Markus
  9. Heemann, Uwe
  10. Strohäker, Jens
  11. Glöckner, Stephan
  12. Mikolajczyk, Rafael
  13. Busch, Dirk H.
  14. Schulz, Thomas F.
  15. Lehmann, Andreas
  16. Ganser, Arnold
  17. Lange, Berit
  18. Maecker-Kolhoff, Britta
  19. Tönshoff, Burkhard
  20. Morath, Christian
  21. Rieger, Christina
  22. Falk, Christine
  23. Schmaderer, Christoph
  24. Pohle, Diana
  25. Sturm, Ekkehard
  26. Jäckel, Elmar
  27. Kohlmayer, Florian
  28. Anton, Gabriele
  29. Krause, Gérard
  30. Wichmann, H.-Erich
  31. Mix, Heiko
  32. Vehreschild, Jörg Janne
  33. Bucher, Julian
  34. Hädicke-Jarboui, Juliane
  35. Weiss, Karl-Heinz
  36. Wagner, Katrin
  37. Pape, Lars
  38. Frey, Lorenz
  39. Renders, Lutz
  40. Verbeek, Mareike
  41. Schiffer, Mario
  42. Zirngibl, Matthias
  43. Kreusser, Michael M.
  44. Neuenhahn, Michael
  45. Geßner, Michaela
  46. Lang, Peter
  47. Nadalin, Silvio
  48. Meuer, Stefan
  49. Giese, Thomas
  50. Iftner, Thomas
  51. Illig, Thomas
  52. Ganzenmüller, Tina
  53. Welte, Tobias
  54. Bethge, Wolfgang

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1000 Titel
  • The transplant cohort of the German center for infection research (DZIF Tx-Cohort): study design and baseline characteristics
1000 Autor/in
  1. Karch, André |
  2. Schindler, Daniela |
  3. Kühn-Steven, Andrea |
  4. Blaser, Rainer |
  5. Kuhn, Klaus A. |
  6. Sandmann, Lisa |
  7. Sommerer, Claudia |
  8. Guba, Markus |
  9. Heemann, Uwe |
  10. Strohäker, Jens |
  11. Glöckner, Stephan |
  12. Mikolajczyk, Rafael |
  13. Busch, Dirk H. |
  14. Schulz, Thomas F. |
  15. Lehmann, Andreas |
  16. Ganser, Arnold |
  17. Lange, Berit |
  18. Maecker-Kolhoff, Britta |
  19. Tönshoff, Burkhard |
  20. Morath, Christian |
  21. Rieger, Christina |
  22. Falk, Christine |
  23. Schmaderer, Christoph |
  24. Pohle, Diana |
  25. Sturm, Ekkehard |
  26. Jäckel, Elmar |
  27. Kohlmayer, Florian |
  28. Anton, Gabriele |
  29. Krause, Gérard |
  30. Wichmann, H.-Erich |
  31. Mix, Heiko |
  32. Vehreschild, Jörg Janne |
  33. Bucher, Julian |
  34. Hädicke-Jarboui, Juliane |
  35. Weiss, Karl-Heinz |
  36. Wagner, Katrin |
  37. Pape, Lars |
  38. Frey, Lorenz |
  39. Renders, Lutz |
  40. Verbeek, Mareike |
  41. Schiffer, Mario |
  42. Zirngibl, Matthias |
  43. Kreusser, Michael M. |
  44. Neuenhahn, Michael |
  45. Geßner, Michaela |
  46. Lang, Peter |
  47. Nadalin, Silvio |
  48. Meuer, Stefan |
  49. Giese, Thomas |
  50. Iftner, Thomas |
  51. Illig, Thomas |
  52. Ganzenmüller, Tina |
  53. Welte, Tobias |
  54. Bethge, Wolfgang |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-25
1000 Erschienen in
1000 Quellenangabe
  • 36(2):233-241
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s10654-020-00715-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987595/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Infectious complications are the major cause of morbidity and mortality after solid organ and stem cell transplantation. To better understand host and environmental factors associated with an increased risk of infection as well as the effect of infections on function and survival of transplanted organs, we established the DZIF Transplant Cohort, a multicentre prospective cohort study within the organizational structure of the German Center for Infection Research. At time of transplantation, heart-, kidney-, lung-, liver-, pancreas- and hematopoetic stem cell- transplanted patients are enrolled into the study. Follow-up visits are scheduled at 3, 6, 9, 12 months after transplantation, and annually thereafter; extracurricular visits are conducted in case of infectious complications. Comprehensive standard operating procedures, web-based data collection and monitoring tools as well as a state of the art biobanking concept for blood, purified PBMCs, urine, and faeces samples ensure high quality of data and biosample collection. By collecting detailed information on immunosuppressive medication, infectious complications, type of infectious agent and therapy, as well as by providing corresponding biosamples, the cohort will establish the foundation for a broad spectrum of studies in the field of infectious diseases and transplant medicine. By January 2020, baseline data and biosamples of about 1400 patients have been collected. We plan to recruit 3500 patients by 2023, and continue follow-up visits and the documentation of infectious events at least until 2025. Information about the DZIF Transplant Cohort is available at https://www.dzif.de/en/working-group/transplant-cohort .
1000 Sacherschließung
lokal Adolescent [MeSH]
lokal Female [MeSH]
lokal Cohort Profile
lokal Immunosuppression [MeSH]
lokal Postoperative Complications [MeSH]
lokal Aged, 80 and over [MeSH]
lokal Aged [MeSH]
lokal Bacterial Infections [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Middle Aged [MeSH]
lokal Immunosuppression
lokal Biological Specimen Banks [MeSH]
lokal Research Design [MeSH]
lokal Infection
lokal Cohort Studies [MeSH]
lokal Organ transplantation
lokal Organ Transplantation [MeSH]
lokal Male [MeSH]
lokal Young Adult [MeSH]
lokal Clinical cohort study
lokal Child [MeSH]
lokal Child, Preschool [MeSH]
1000 Liste der Beteiligten
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