The bile acid-sensitive ion channel (BASIC) mediates bile acid-dependent currents in bile duct epithelial cells

  1. Wiegreffe, Shari
  2. Löhrer, Daniel
  3. Wirtz, Monika
  4. Wiemuth, Dominik ORCID logo

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1000 Titel
  • The bile acid-sensitive ion channel (BASIC) mediates bile acid-dependent currents in bile duct epithelial cells
1000 Autor/in
  1. Wiegreffe, Shari |
  2. Löhrer, Daniel |
  3. Wirtz, Monika |
  4. Wiemuth, Dominik |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-09-21
1000 Erschienen in
1000 Quellenangabe
  • 473(12):1841-1850
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00424-021-02622-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599227/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The bile acid-sensitive ion channel (BASIC) is a member of the Deg/ENaC family of ion channels that is activated by bile acids. Despite the identification of cholangiocytes in the liver and unipolar brush cells in the cerebellum as sites of expression, the physiological function of BASIC in these cell types is not yet understood. Here we used a cholangiocyte cell line, normal rat cholangiocytes (NRCs), which expresses BASIC to study the role of the channel in epithelial transport using Ussing chamber experiments. Apical application of bile acids induced robust and transient increases in transepithelial currents that were carried by Na
1000 Sacherschließung
lokal Bile Ducts/metabolism [MeSH]
lokal Ion Channels, Receptors and Transporters
lokal Liver/metabolism [MeSH]
lokal Cell Line [MeSH]
lokal BASIC
lokal Rats [MeSH]
lokal Cation channel
lokal Cholangiocyte
lokal Animals [MeSH]
lokal Deg/ENaC
lokal Epithelial Cells/metabolism [MeSH]
lokal Ion channels, receptors and transporters
lokal Bile Acids and Salts/metabolism [MeSH]
lokal BLINaC
lokal Bile/metabolism [MeSH]
lokal Sodium/metabolism [MeSH]
lokal Acid Sensing Ion Channels/metabolism [MeSH]
lokal Bile acid
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/V2llZ3JlZmZlLCBTaGFyaQ==|https://frl.publisso.de/adhoc/uri/TMO2aHJlciwgRGFuaWVs|https://frl.publisso.de/adhoc/uri/V2lydHosIE1vbmlrYQ==|https://orcid.org/0000-0002-0563-4198
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1000 Erstellt am 2023-04-28T14:35:32.448+0200
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1000 Zuletzt bearbeitet 2023-10-20T19:16:05.920+0200
1000 Objekt bearb. Fri Oct 20 19:16:05 CEST 2023
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