Myostatin regulates the production of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast–like cells

  1. Ewendt, Franz
  2. Feger, Martina
  3. Föller, Michael ORCID logo

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WeightNameValue
1000 Titel
  • Myostatin regulates the production of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast–like cells
1000 Autor/in
  1. Ewendt, Franz |
  2. Feger, Martina |
  3. Föller, Michael |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-25
1000 Erschienen in
1000 Quellenangabe
  • 473(6):969-976
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00424-021-02561-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164604/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Myostatin is a signaling molecule produced by skeletal muscle cells (myokine) that inhibits muscle hypertrophy and has further paracrine and endocrine effects in other organs including bone. Myostatin binds to activin receptor type 2B which forms a complex with transforming growth factor-β type I receptor (TGF-βRI) and induces intracellular p38MAPK and NFκB signaling. Fibroblast growth factor 23 (FGF23) is a paracrine and endocrine mediator produced by bone cells and regulates phosphate and vitamin D metabolism in the kidney. P38MAPK and NFκB-dependent store-operated Ca
1000 Sacherschließung
lokal Cell Line, Tumor [MeSH]
lokal Activin Receptors/metabolism [MeSH]
lokal Cell Line [MeSH]
lokal Fibroblast Growth Factor-23/genetics [MeSH]
lokal Osteoblasts/metabolism [MeSH]
lokal Signaling and cell physiology
lokal Withanolides/pharmacology [MeSH]
lokal TGF-β
lokal Phosphate
lokal p38 Mitogen-Activated Protein Kinases/antagonists
lokal Signaling and Cell Physiology
lokal Vitamin D
lokal Imidazoles/pharmacology [MeSH]
lokal Benzamides/pharmacology [MeSH]
lokal Pyridines/pharmacology [MeSH]
lokal Calcium/metabolism [MeSH]
lokal Protein Kinase Inhibitors/pharmacology [MeSH]
lokal NF-kappa B/antagonists
lokal Fibroblast Growth Factor-23/metabolism [MeSH]
lokal Rats [MeSH]
lokal Animals [MeSH]
lokal Mice [MeSH]
lokal NF-kappa B/metabolism [MeSH]
lokal Ca
lokal Myostatin/pharmacology [MeSH]
lokal p38 Mitogen-Activated Protein Kinases/metabolism [MeSH]
lokal p38MAPK
lokal Dioxoles/pharmacology [MeSH]
lokal Osteoblasts/drug effects [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/RXdlbmR0LCBGcmFueg==|https://frl.publisso.de/adhoc/uri/RmVnZXIsIE1hcnRpbmE=|https://orcid.org/0000-0003-2074-4827
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1000 Erstellt am 2023-04-28T14:41:15.634+0200
1000 Erstellt von 322
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1000 Zuletzt bearbeitet 2023-10-20T19:18:39.698+0200
1000 Objekt bearb. Fri Oct 20 19:18:39 CEST 2023
1000 Vgl. frl:6446960
1000 Oai Id
  1. oai:frl.publisso.de:frl:6446960 |
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