The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study

  1. Öztürk, Ömer Faruk ORCID logo
  2. Pigoni, Alessandro
  3. Wenzel, Julian
  4. Haas, Shalaila S.
  5. Popovic, David
  6. Ruef, Anne
  7. Dwyer, Dominic B.
  8. Kambeitz-Ilankovic, Lana
  9. Ruhrmann, Stephan
  10. Chisholm, Katharine
  11. Lalousis, Paris
  12. Griffiths, Sian Lowri
  13. Lichtenstein, Theresa
  14. Rosen, Marlene
  15. Kambeitz, Joseph
  16. Schultze-Lutter, Frauke
  17. Liddle, Peter
  18. Upthegrove, Rachel
  19. Salokangas, Raimo K. R.
  20. Pantelis, Christos
  21. Meisenzahl, Eva
  22. Wood, Stephen J.
  23. Brambilla, Paolo
  24. Borgwardt, Stefan
  25. Falkai, Peter
  26. Antonucci, Linda A.
  27. Koutsouleris, Nikolaos

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1000 Titel
  • The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study
1000 Autor/in
  1. Öztürk, Ömer Faruk |
  2. Pigoni, Alessandro |
  3. Wenzel, Julian |
  4. Haas, Shalaila S. |
  5. Popovic, David |
  6. Ruef, Anne |
  7. Dwyer, Dominic B. |
  8. Kambeitz-Ilankovic, Lana |
  9. Ruhrmann, Stephan |
  10. Chisholm, Katharine |
  11. Lalousis, Paris |
  12. Griffiths, Sian Lowri |
  13. Lichtenstein, Theresa |
  14. Rosen, Marlene |
  15. Kambeitz, Joseph |
  16. Schultze-Lutter, Frauke |
  17. Liddle, Peter |
  18. Upthegrove, Rachel |
  19. Salokangas, Raimo K. R. |
  20. Pantelis, Christos |
  21. Meisenzahl, Eva |
  22. Wood, Stephen J. |
  23. Brambilla, Paolo |
  24. Borgwardt, Stefan |
  25. Falkai, Peter |
  26. Antonucci, Linda A. |
  27. Koutsouleris, Nikolaos |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-09-17
1000 Erschienen in
1000 Quellenangabe
  • 272(3):403-413
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00406-021-01327-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938366/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background: Formal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup of patients showing more prominent illness severity, neurocognitive and functional impairments. This study aimed to identify stable and generalizable FTD-subgroups of patients with recent-onset psychosis (ROP) by applying a comprehensive data-driven clustering approach and to test the validity of these subgroups by assessing associations between this FTD-related stratification, social and occupational functioning, and neurocognition. Methods: 279 patients with ROP were recruited as part of the multi-site European PRONIA study (Personalised Prognostic Tools for Early Psychosis Management; www.pronia.eu). Five FTD-related symptoms (conceptual disorganization, poverty of content of speech, difficulty in abstract thinking, increased latency of response and poverty of speech) were assessed with Positive and Negative Symptom Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS). Results: The results with two patient subgroups showing different levels of FTD were the most stable and generalizable clustering solution (predicted clustering strength value = 0.86). FTD-High subgroup had lower scores in social (pfdr < 0.001) and role (pfdr < 0.001) functioning, as well as worse neurocognitive performance in semantic (pfdr < 0.001) and phonological verbal fluency (pfdr < 0.001), short-term verbal memory (pfdr = 0.002) and abstract thinking (pfdr = 0.010), in comparison to FTD-Low group. Results: Clustering techniques allowed us to identify patients with more pronounced FTD showing more severe deficits in functioning and neurocognition, thus suggesting that FTD may be a relevant marker of illness severity in the early psychosis pathway.
1000 Sacherschließung
lokal Formal thought disorder
lokal Early psychosis
lokal Humans [MeSH]
lokal Semantics [MeSH]
lokal Functioning
lokal Psychotic Disorders/complications [MeSH]
lokal Clustering
lokal Neurocognition
lokal Psychotic Disorders/psychology [MeSH]
lokal Psychotic Disorders/diagnosis [MeSH]
lokal Original Paper
lokal Thinking/physiology [MeSH]
lokal Cognition [MeSH]
lokal Memory, Short-Term [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2023-04-28T15:29:26.848+0200
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