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1000 Titel
  • Association between formal thought disorders, neurocognition and functioning in the early stages of psychosis: a systematic review of the last half-century studies
1000 Autor/in
  1. Öztürk, Ömer Faruk |
  2. Pigoni, Alessandro |
  3. Antonucci, Linda A. |
  4. Koutsouleris, Nikolaos |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-14
1000 Erschienen in
1000 Quellenangabe
  • 272(3):381-393
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00406-021-01295-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938342/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Recent review articles provided an extensive collection of studies covering many aspects of formal thought disorders (FTD) among their epidemiology and phenomenology, their neurobiological underpinnings, genetics as well as their transdiagnostic prevalence. However, less attention has been paid to the association of FTD with neurocognitive and functioning deficits in the early stages of evolving psychosis. Therefore, this systematic review aims to investigate the state of the art regarding the association between FTD, neurocognition and functioning in the early stages of evolving psychotic disorders in adolescents and young adults, by following the PRISMA flowchart. A total of 106 studies were screened. We included 8 studies due to their reports of associations between FTD measures and functioning outcomes measured with different scales and 7 studies due to their reports of associations between FTD measures and neurocognition. In summary, the main findings of the included studies for functioning outcomes showed that FTD severity predicted poor social functioning, unemployment, relapses, re-hospitalisations, whereas the main findings of the included studies for neurocognition showed correlations between attentional deficits, executive functions and FTD, and highlighted the predictive potential of executive dysfunctions for sustained FTD. Further studies in upcoming years taking advantage of the acceleration in computational psychiatry would allow researchers to re-investigate the clinical importance of FTD and their role in the transition from at-risk to full-blown psychosis conditions. Employing automated computer-assisted diagnostic tools in the early stages of psychosis might open new avenues to develop targeted neuropsychotherapeutics specific to FTD.
1000 Sacherschließung
lokal Formal thought disorder
lokal Adolescent [MeSH]
lokal Invited Review
lokal Executive Function [MeSH]
lokal Clinical high risk
lokal Social Adjustment [MeSH]
lokal Humans [MeSH]
lokal Functioning
lokal Psychosis
lokal Psychotic Disorders/epidemiology [MeSH]
lokal Neurocognition
lokal Young Adult [MeSH]
lokal Cognition [MeSH]
lokal Neuropsychological Tests [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-3665-0526|https://frl.publisso.de/adhoc/uri/UGlnb25pLCBBbGVzc2FuZHJv|https://frl.publisso.de/adhoc/uri/QW50b251Y2NpLCBMaW5kYSBBLg==|https://frl.publisso.de/adhoc/uri/S291dHNvdWxlcmlzLCBOaWtvbGFvcw==
1000 Hinweis
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1000 Erstellt am 2023-04-28T15:32:51.691+0200
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1000 Zuletzt bearbeitet 2023-10-20T20:20:16.485+0200
1000 Objekt bearb. Fri Oct 20 20:20:16 CEST 2023
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