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1000 Titel
  • Determining prognostic variables of treatment outcome in obsessive–compulsive disorder: effectiveness and its predictors in routine clinical care
1000 Autor/in
  1. Herzog, Philipp |
  2. Osen, Bernhard |
  3. Stierle, Christian |
  4. Middendorf, Thomas |
  5. Voderholzer, Ulrich |
  6. Koch, Stefan |
  7. Feldmann, Matthias |
  8. Rief, Winfried |
  9. Brakemeier, Eva-Lotta |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-03
1000 Erschienen in
1000 Quellenangabe
  • 272(2):313-326
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00406-021-01284-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866294/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The objectives of this study were to investigate the naturalistic effectiveness of routine inpatient treatment for patients with obsessive-compulsive disorder (OCD) and to identify predictors of treatment outcome. A routinely collected data set of 1,596 OCD inpatients (M = 33.9 years, SD = 11.7; 60.4% female) having received evidence-based psychotherapy based on the cognitive-behavioral therapy (CBT) in five German psychotherapeutic clinics was analyzed. Effect sizes (Hedges' g) were calculated for several outcome variables to determine effectiveness. Predictor analyses were performed on a subsample (N = 514; M = 34.3 years, SD = 12.2; 60.3% female). For this purpose, the number of potential predictors was reduced using factor analysis, followed by multiple regression analysis to identify robust predictors. Effect sizes of various outcome variables could be classified as large (g = 1.34 of OCD-symptom change). Predictors of changes in OCD and depressive symptoms were symptom severity at admission and general psychopathological distress. In addition, patients with higher social support and more washing compulsions benefited more from treatment. Subgroup analyses showed a distinct predictor profile of changes in compulsions and obsessions. The results indicate that an evidence-based psychotherapy program for OCD can be effectively implemented in routine inpatient care. In addition to well-established predictors, social support, and washing compulsions in particular were identified as important positive predictors. Specific predictor profiles for changes in obsessions and compulsions are discussed.
1000 Sacherschließung
lokal Female [MeSH]
lokal Obsessive–compulsive disorder
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Treatment Outcome [MeSH]
lokal Patient characteristics
lokal Prognostic variables
lokal Predictors
lokal Male [MeSH]
lokal Obsessive-Compulsive Disorder/therapy [MeSH]
lokal Original Paper
lokal Prognosis [MeSH]
lokal Effectiveness
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-8267-2083|https://frl.publisso.de/adhoc/uri/T3NlbiwgQmVybmhhcmQ=|https://frl.publisso.de/adhoc/uri/U3RpZXJsZSwgQ2hyaXN0aWFu|https://frl.publisso.de/adhoc/uri/TWlkZGVuZG9yZiwgVGhvbWFz|https://frl.publisso.de/adhoc/uri/Vm9kZXJob2x6ZXIsIFVscmljaA==|https://frl.publisso.de/adhoc/uri/S29jaCwgU3RlZmFu|https://frl.publisso.de/adhoc/uri/RmVsZG1hbm4sIE1hdHRoaWFz|https://frl.publisso.de/adhoc/uri/UmllZiwgV2luZnJpZWQ=|https://frl.publisso.de/adhoc/uri/QnJha2VtZWllciwgRXZhLUxvdHRh
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1000 Erstellt am 2023-04-28T15:34:49.026+0200
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