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1000 Titel
  • Utility of pT3 substaging in lymph node-negative urothelial carcinoma of the bladder: do pathologic parameters add to prognostic sub-stratification?
1000 Autor/in
  1. Maas, Moritz |
  2. Mischinger, Johannes |
  3. Compérat, Eva |
  4. Scharpf, Marcus |
  5. Fend, Falko |
  6. Todenhöfer, Tilman |
  7. Stenzl, Arnulf |
  8. Gakis, Georgios |
  9. Rausch, Steffen |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-21
1000 Erschienen in
1000 Quellenangabe
  • 39(11):4021-4027
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00345-021-03697-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571207/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!The value of bladder cancer (BC) substaging into macroscopic (pT3b) and microscopic (pT3a) perivesical fat extension in lymph node (Ln)-negative patients is controversially discussed and limited evidence for prognostic relevance of additional histopathological factors in pT3 BC exists. We evaluated the prognostic value of pT3 substaging and established pathological and clinical parameters with focus on tumor invasive front (TIF) and tumor size.!##!Methods!#!Specimens of 52 patients treated with radical cystectomy (RC) for pT3 a/b muscle-invasive BC were reviewed and re-evaluated by a pathologist specialized in uropathology. Clinical variables and standard histopathologic characteristics were assessed including TIF and tumor size. Their value as prognosticators for overall survival (OS) and recurrence-free survival (RFS) was evaluated.!##!Results!#!Mean age of patients was 67.55 years. Tumors were staged pT3a in 28 patients (53.8%) and pT3b in 24 (46.8%). Median OS was 34.51 months. Median tumor size was 3.2 cm, median TIF was 11.0 mm. Differences in OS between pT3a and pT3b were not significant (p = 0.45). Carcinoma in situ (CIS) and lymphovascular invasion (LVI) were significantly associated with pT3b tumors. Univariate analysis could not identify pathological prognosticators like TIF or tumor size for OS and RFS (p for all > 0.05).!##!Conclusion!#!No significant differences in OS or RFS were observed comparing Ln-negative pT3 BC following radical cystectomy. Additional pathologic variables like TIF could not be identified as prognosticator. Relevance of pT3 BC substaging needs reevaluation in larger prospective cohorts.
1000 Sacherschließung
lokal Topic Paper
lokal Aged, 80 and over [MeSH]
lokal Aged [MeSH]
lokal Tumor invasion front
lokal Urinary Bladder Neoplasms/classification [MeSH]
lokal Carcinoma, Transitional Cell/pathology [MeSH]
lokal Neoplasm Staging [MeSH]
lokal Male [MeSH]
lokal Lymph Nodes [MeSH]
lokal Tumor Burden [MeSH]
lokal Carcinoma, Transitional Cell/mortality [MeSH]
lokal Muscle-invasive bladder cancer
lokal Carcinoma, Transitional Cell/classification [MeSH]
lokal Female [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Retrospective Studies [MeSH]
lokal Urinary Bladder Neoplasms/mortality [MeSH]
lokal Middle Aged [MeSH]
lokal Urinary Bladder Neoplasms/pathology [MeSH]
lokal Survival Rate [MeSH]
lokal Prognosis [MeSH]
lokal Perivesical extension
lokal Pathological staging
lokal Patient outcome
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TWFhcywgTW9yaXR6|https://frl.publisso.de/adhoc/uri/TWlzY2hpbmdlciwgSm9oYW5uZXM=|https://frl.publisso.de/adhoc/uri/Q29tcMOpcmF0LCBFdmE=|https://frl.publisso.de/adhoc/uri/U2NoYXJwZiwgTWFyY3Vz|https://frl.publisso.de/adhoc/uri/RmVuZCwgRmFsa28=|https://frl.publisso.de/adhoc/uri/VG9kZW5ow7ZmZXIsIFRpbG1hbg==|https://frl.publisso.de/adhoc/uri/U3RlbnpsLCBBcm51bGY=|https://frl.publisso.de/adhoc/uri/R2FraXMsIEdlb3JnaW9z|https://frl.publisso.de/adhoc/uri/UmF1c2NoLCBTdGVmZmVu
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1000 Erstellt am 2023-05-03T16:14:11.232+0200
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