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1000 Titel
  • Autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction: similar short-term results in comparison with isolated cartilage repair in ligament intact joints
1000 Autor/in
  1. Mehl, Julian |
  2. Feucht, Matthias |
  3. Achtnich, Andrea |
  4. Imhoff, Andreas B. |
  5. Niemeyer, Philipp |
  6. Angele, Peter |
  7. Zinser, Wolfgang |
  8. Spahn, Gunter |
  9. Loer, Ingo |
  10. Kniffler, Heino |
  11. Schauf, Gunnar |
  12. Schmitt, Andreas |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-10-09
1000 Erschienen in
1000 Quellenangabe
  • 30(10):3249-3257
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00167-021-06764-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464143/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!Both acute ruptures of the anterior cruciate ligament (ACL) as well as chronic ACL insufficiency show a high association with focal cartilage defects of the knee. However, the results after combined ACL reconstruction and cartilage repair are not well investigated. The aim of the present study was to investigate the short-term outcomes after autologous chondrocyte implantation (ACI) in combination with ACL reconstruction and to compare the results with patients who underwent isolated ACI in ligament intact knees.!##!Methods!#!All patients who were registered in the German Cartilage Registry with ACI for focal cartilage defects in the knee joint in combination with ACL reconstruction and who completed the 24 month follow-up were included in the study group. A matched-pair procedure according to gender, defect location, defect size, and age was used to create a control group of patients with isolated ACI in ACL intact joints. The Knee Injury and Osteoarthritis Outcome Score (KOOS) and the numeric analog scale for pain (NAS) were used to assess the preoperative state as well as the clinical outcomes 12 and 24 months after surgery.!##!Results!#!A total of 34 patients were included in both the study group (age mean 33.3 ± SD 8.8 years) and the control group (33.6 ± 8.4 years) with a median defect size of 466 (25%-75% IQR 375-600) mm!##!Conclusion!#!The clinical short-term outcomes after ACI at the knee joint in combination with ACL reconstruction are good and similar to the results after isolated ACI in ligament intact knees.!##!Level of evidence!#!III.
1000 Sacherschließung
lokal Pain/surgery [MeSH]
lokal Follow-Up Studies [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Knee Joint/surgery [MeSH]
lokal Osteoarthritis, Knee/surgery [MeSH]
lokal Cartilage repair
lokal ACL
lokal Anterior Cruciate Ligament Injuries/complications [MeSH]
lokal Anterior Cruciate Ligament Injuries/surgery [MeSH]
lokal Knee
lokal Ligament
lokal Cartilage Diseases/surgery [MeSH]
lokal Autologous chondrocyte implantation
lokal Anterior Cruciate Ligament Reconstruction/methods [MeSH]
lokal Anterior Cruciate Ligament/surgery [MeSH]
lokal Chondrocytes [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-9965-5722|https://frl.publisso.de/adhoc/uri/RmV1Y2h0LCBNYXR0aGlhcw==|https://frl.publisso.de/adhoc/uri/QWNodG5pY2gsIEFuZHJlYQ==|https://frl.publisso.de/adhoc/uri/SW1ob2ZmLCBBbmRyZWFzIEIu|https://frl.publisso.de/adhoc/uri/TmllbWV5ZXIsIFBoaWxpcHA=|https://frl.publisso.de/adhoc/uri/QW5nZWxlLCBQZXRlcg==|https://frl.publisso.de/adhoc/uri/Wmluc2VyLCBXb2xmZ2FuZw==|https://frl.publisso.de/adhoc/uri/U3BhaG4sIEd1bnRlcg==|https://frl.publisso.de/adhoc/uri/TG9lciwgSW5nbw==|https://frl.publisso.de/adhoc/uri/S25pZmZsZXIsIEhlaW5v|https://frl.publisso.de/adhoc/uri/U2NoYXVmLCBHdW5uYXI=|https://frl.publisso.de/adhoc/uri/U2NobWl0dCwgQW5kcmVhcw==
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1000 Erstellt am 2023-05-03T17:09:27.477+0200
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