Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial

  1. Dietzsch, Stefan ORCID logo
  2. Braesigk, Annett
  3. Seidel, Clemens
  4. Remmele, Julia
  5. Kitzing, Ralf
  6. Schlender, Tina
  7. Mynarek, Martin
  8. Geismar, Dirk
  9. Jablonska, Karolina
  10. Schwarz, Rudolf
  11. Pazos, Montserrat
  12. Weber, Damien C.
  13. Frick, Silke
  14. Gurtner, Kristin
  15. Matuschek, Christiane
  16. Harrabi, Semi Ben
  17. Glück, Albrecht
  18. Lewitzki, Victor
  19. Dieckmann, Karin
  20. Benesch, Martin
  21. Gerber, Nicolas U.
  22. Obrecht, Denise
  23. Rutkowski, Stefan
  24. Timmermann, Beate
  25. Kortmann, Rolf-Dieter

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1000 Titel
  • Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
1000 Autor/in
  1. Dietzsch, Stefan |
  2. Braesigk, Annett |
  3. Seidel, Clemens |
  4. Remmele, Julia |
  5. Kitzing, Ralf |
  6. Schlender, Tina |
  7. Mynarek, Martin |
  8. Geismar, Dirk |
  9. Jablonska, Karolina |
  10. Schwarz, Rudolf |
  11. Pazos, Montserrat |
  12. Weber, Damien C. |
  13. Frick, Silke |
  14. Gurtner, Kristin |
  15. Matuschek, Christiane |
  16. Harrabi, Semi Ben |
  17. Glück, Albrecht |
  18. Lewitzki, Victor |
  19. Dieckmann, Karin |
  20. Benesch, Martin |
  21. Gerber, Nicolas U. |
  22. Obrecht, Denise |
  23. Rutkowski, Stefan |
  24. Timmermann, Beate |
  25. Kortmann, Rolf-Dieter |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-08-05
1000 Erschienen in
1000 Quellenangabe
  • 198(3):282-290
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00066-021-01822-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863746/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost.!##!Patients and methods!#!A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly.!##!Results!#!Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity.!##!Conclusion!#!In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed.
1000 Sacherschließung
lokal Cerebellar Neoplasms/radiotherapy [MeSH]
lokal Focal radiotherapy
lokal Medulloblastoma/radiotherapy [MeSH]
lokal Radiotherapy Planning, Computer-Assisted [MeSH]
lokal Humans [MeSH]
lokal Quality Control [MeSH]
lokal Radiation Oncology [MeSH]
lokal Original Article
lokal Individual case review
lokal Brain tumor
lokal Germany [MeSH]
lokal Pediatric
lokal Quality assurance
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-6141-2170|https://frl.publisso.de/adhoc/uri/QnJhZXNpZ2ssIEFubmV0dA==|https://frl.publisso.de/adhoc/uri/U2VpZGVsLCBDbGVtZW5z|https://frl.publisso.de/adhoc/uri/UmVtbWVsZSwgSnVsaWE=|https://frl.publisso.de/adhoc/uri/S2l0emluZywgUmFsZg==|https://frl.publisso.de/adhoc/uri/U2NobGVuZGVyLCBUaW5h|https://frl.publisso.de/adhoc/uri/TXluYXJlaywgTWFydGlu|https://frl.publisso.de/adhoc/uri/R2Vpc21hciwgRGlyaw==|https://frl.publisso.de/adhoc/uri/SmFibG9uc2thLCBLYXJvbGluYQ==|https://frl.publisso.de/adhoc/uri/U2Nod2FyeiwgUnVkb2xm|https://frl.publisso.de/adhoc/uri/UGF6b3MsIE1vbnRzZXJyYXQ=|https://frl.publisso.de/adhoc/uri/V2ViZXIsIERhbWllbiBDLg==|https://frl.publisso.de/adhoc/uri/RnJpY2ssIFNpbGtl|https://frl.publisso.de/adhoc/uri/R3VydG5lciwgS3Jpc3Rpbg==|https://frl.publisso.de/adhoc/uri/TWF0dXNjaGVrLCBDaHJpc3RpYW5l|https://frl.publisso.de/adhoc/uri/SGFycmFiaSwgU2VtaSBCZW4=|https://frl.publisso.de/adhoc/uri/R2zDvGNrLCBBbGJyZWNodA==|https://frl.publisso.de/adhoc/uri/TGV3aXR6a2ksIFZpY3Rvcg==|https://frl.publisso.de/adhoc/uri/RGllY2ttYW5uLCBLYXJpbg==|https://frl.publisso.de/adhoc/uri/QmVuZXNjaCwgTWFydGlu|https://frl.publisso.de/adhoc/uri/R2VyYmVyLCBOaWNvbGFzIFUu|https://frl.publisso.de/adhoc/uri/T2JyZWNodCwgRGVuaXNl|https://frl.publisso.de/adhoc/uri/UnV0a293c2tpLCBTdGVmYW4=|https://frl.publisso.de/adhoc/uri/VGltbWVybWFubiwgQmVhdGU=|https://frl.publisso.de/adhoc/uri/S29ydG1hbm4sIFJvbGYtRGlldGVy
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1000 Erstellt am 2023-05-03T18:54:20.463+0200
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1000 Zuletzt bearbeitet 2023-10-20T22:59:44.053+0200
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