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1000 Titel
  • Long-term outcome and quality of life after CNS cavernoma resection: eloquent vs. non-eloquent areas
1000 Autor/in
  1. Shoubash, Loay |
  2. Baldauf, Jörg |
  3. Matthes, Marc |
  4. Kirsch, Michael |
  5. Rath, Matthias |
  6. Felbor, Ute |
  7. Schroeder, Henry W. S. |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-06-23
1000 Erschienen in
1000 Quellenangabe
  • 45(1):649-660
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s10143-021-01572-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827309/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The aim of this study is to analyze the long-term quality of life after surgery of cavernoma. A monocentric retrospective study was conducted on 69 patients with cavernoma treated microsurgically between 2000 and 2016. The eloquence was adopted from Spetzler-Martin definition. A most recent follow-up was elicited between 2017 and 2019, in which the quality of life (QoL) was evaluated with the Short Form-12 questionnaire (SF12). Forty-one lesions were in eloquent group (EG), 22 in non-eloquent group (NEG), 3 in orbit, and 3 in the spinal cord. Postoperative worsening of the modified Rankin scale (mRS) occurred in 19.5% of cases in EG versus 4.5% in NEG. After a mean follow-up of 6.5 years (SD 4.6), the neurological status was better or unchanged compared to baseline in 85.4% of EG and 100% of NEG. Regarding QoL assessment of 44 patients (EG n = 27, NEG n = 14) attended the last follow-up. Patients after eloquent cavernoma resection reported a non-inferior QoL in most SF12 domains (except for physical role) compared to NEG. However, they reported general health perception inferior to norms, which was affected by the limited physical and emotional roles. At a late follow-up, the surgical morbidity was transient in the NEG and mostly recovered in the EG. The QoL comparison between eloquent and non-eloquent cavernomas created interesting and new data after prolonged follow-up. These results add value for decision-making as well as patient counseling for future encountered cases. Preoperative evaluation of QoL is recommended for future studies to assess QoL dynamics.
1000 Sacherschließung
lokal Cavernous malformation
lokal Preoperative Care [MeSH]
lokal Surgical resection
lokal Humans [MeSH]
lokal Cavernoma
lokal Treatment Outcome [MeSH]
lokal Retrospective Studies [MeSH]
lokal Hemangioma, Cavernous/surgery [MeSH]
lokal Original Article
lokal Quality of life
lokal Quality of Life [MeSH]
lokal Neurological outcome
lokal Eloquent area
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-0433-832X|https://frl.publisso.de/adhoc/uri/QmFsZGF1ZiwgSsO2cmc=|https://frl.publisso.de/adhoc/uri/TWF0dGhlcywgTWFyYw==|https://frl.publisso.de/adhoc/uri/S2lyc2NoLCBNaWNoYWVs|https://frl.publisso.de/adhoc/uri/UmF0aCwgTWF0dGhpYXM=|https://frl.publisso.de/adhoc/uri/RmVsYm9yLCBVdGU=|https://frl.publisso.de/adhoc/uri/U2Nocm9lZGVyLCBIZW5yeSBXLiBTLg==
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1000 Erstellt am 2023-05-04T10:37:01.004+0200
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1000 Zuletzt bearbeitet 2023-10-20T23:49:44.901+0200
1000 Objekt bearb. Fri Oct 20 23:49:44 CEST 2023
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