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WeightNameValue
1000 Titel
  • Seminal lipid profiling and antioxidant capacity: A species comparison
1000 Autor/in
  1. Jakop, Ulrike |
  2. Müller, Karin |
  3. Müller, Peter |
  4. Neuhauser, Stefanie |
  5. Callealta, Isabel |
  6. Grunewald, Sonja |
  7. Schiller, Jurgen |
  8. , |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-03-08
1000 Erschienen in
1000 Quellenangabe
  • 17(3):e0264675
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0264675 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903242/ |
1000 Ergänzendes Material
  • https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0264675#sec031 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • On their way to the oocyte, sperm cells are subjected to oxidative stress, which may trigger the oxidation of phospholipids (PL). Applying MALDI-TOF MS, HPTLC and ESI-IT MS, we comparatively analyzed the PL compositions of semen and blood of species differing in their reproductive systems and types of nutrition (bull, boar, stallion, lion and man) with regard to the sensitivity to oxidation as well as the accumulation of harmful lyso-PL (LPL), transient products of lipid oxidation. In addition, the protective capacity of seminal fluid (SF) was also examined. The PL composition of erythrocytes and blood plasma is similar across the species, while pronounced differences exist for sperm and SF. Since the blood function is largely conserved across mammalian species, but the reproductive systems may vary in many aspects, the obtained results suggest that the PL composition is not determined by the type of nutrition, but by the relatedness of species and by functional requirements of cell membranes such as fluidity. Sperm motion and fertilization of oocytes require a rather flexible membrane, which is accomplished by significant moieties of unsaturated fatty acyl residues in sperm lipids of most species, but implies a higher risk of oxidation. Due to a high content of plasmalogens (alkenyl ether lipids), bull sperm are most susceptible to oxidation. Our data indicate that bull sperm possess the most effective protective power in SF. Obviously, a co-evolution of PL composition and protective mechanisms has occurred in semen and is related to the reproductive characteristics. Although the protective capacity in human SF seems well developed, we recorded the most pronounced individual contaminations with LPL in human semen. Probably, massive oxidative challenges related to lifestyle factors interfere with natural conditions.
1000 Sacherschließung
lokal Swine [MeSH]
lokal Multidisciplinary
lokal Humans [MeSH]
lokal Oxidative Stress [MeSH]
lokal Horses [MeSH]
lokal Mammals/metabolism [MeSH]
lokal Animals [MeSH]
lokal Semen/metabolism [MeSH]
lokal Spermatozoa/metabolism [MeSH]
lokal Male [MeSH]
lokal Cattle [MeSH]
lokal Antioxidants/metabolism [MeSH]
lokal Cell Membrane/metabolism [MeSH]
lokal Phospholipids/metabolism [MeSH]
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1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/SmFrb3AsIFVscmlrZQ==|https://orcid.org/0000-0003-1749-4863|https://frl.publisso.de/adhoc/uri/TcO8bGxlciwgUGV0ZXI=|https://frl.publisso.de/adhoc/uri/TmV1aGF1c2VyLCBTdGVmYW5pZQ==|https://orcid.org/0000-0002-7028-4139|https://frl.publisso.de/adhoc/uri/R3J1bmV3YWxkLCBTb25qYQ==|https://frl.publisso.de/adhoc/uri/U2NoaWxsZXIsIEp1cmdlbg==|https://orcid.org/0000-0003-0611-7042
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  1. Seminal lipid profiling and antioxidant capacity: A species comparison
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1000 Erstellt am 2023-05-05T08:52:29.200+0200
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1000 Zuletzt bearbeitet 2023-06-01T11:00:59.616+0200
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