ijms-23-09067-v2.pdf 9,04MB
1000 Titel
  • Unique Features of the Tissue Structure in the Naked Mole Rat (Heterocephalus glaber): Hypertrophy of the Endoplasmic Reticulum and Spatial Mitochondrial Rearrangements in Hepatocytes
1000 Autor/in
  1. Vays, Valeriya |
  2. Vangeli, Irina |
  3. Eldarov, Chupalav |
  4. Popkov, Vasily |
  5. Holtze, Susanne |
  6. Hildebrandt, Thomas Bernd |
  7. Averina, Olga |
  8. Zorov, Dmitry |
  9. Bakeeva, Lora |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-08-13
1000 Erschienen in
1000 Quellenangabe
  • 23(16):9067
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • |
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The reason for the exceptional longevity of the naked mole rat (Heterocephalus glaber) remains a mystery to researchers. We assumed that evolutionarily, H. glaber acquired the ability to quickly stabilize the functioning of mitochondria and endoplasmic reticulum (ER) to adjust metabolism to external challenges. To test this, a comparison of the hepatic mitochondria and ER of H. glaber and C57BL/6 mice was done. Electron microscopy showed that 2-months-old mice have more developed rough ER (RER) than smooth ER (SER), occupying ~17 and 2.5% of the hepatocytic area correspondingly, and these values do not change with age. On the other hand, in 1-week-old H. glaber, RER occupies only 13% constantly decreasing with age, while SER occupies 35% in a 1-week-old animal, constantly rising with age. The different localization of mitochondria in H. glaber and mouse hepatocytes was confirmed by confocal and electron microscopy: while in H. glaber, mitochondria were mainly clustered around the nucleus and on the periphery of the cell, in mouse hepatocytes they were evenly distributed throughout the cell. We suggest that the noted structural and spatial features of ER and mitochondria in H. glaber reflect adaptive rearrangements aimed at greater tolerance of the cellular system to challenges, primarily hypoxia and endogenous and exogenous toxins. Different mechanisms of adaptive changes including an activated hepatic detoxification system as a hormetic response, are discussed considering the specific metabolic features of the naked mole rat.
1000 Sacherschließung
lokal Endoplasmic Reticulum [MeSH]
lokal mitochondria
lokal Mice, Inbred C57BL [MeSH]
lokal Spectroscopy
lokal Catalysis
lokal Mitochondria [MeSH]
lokal Computer Science Applications
lokal electron microscopy
lokal Animals [MeSH]
lokal Hypertrophy [MeSH]
lokal naked mole rat
lokal Hepatocytes [MeSH]
lokal General Medicine
lokal Mice [MeSH]
lokal Inorganic Chemistry
lokal hepatocytes
lokal Organic Chemistry
lokal Mole Rats [MeSH]
lokal Physical and Theoretical Chemistry
lokal Molecular Biology
lokal endoplasmic reticulum
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 Label
1000 Förderer
  1. Russian Science Foundation |
1000 Fördernummer
  1. 19-14-00173
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Russian Science Foundation |
    1000 Förderprogramm -
    1000 Fördernummer 19-14-00173
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6449440.rdf
1000 Erstellt am 2023-05-05T09:07:37.657+0200
1000 Erstellt von 336
1000 beschreibt frl:6449440
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Tue Jun 06 09:22:24 CEST 2023
1000 Objekt bearb. Tue Jun 06 09:21:55 CEST 2023
1000 Vgl. frl:6449440
1000 Oai Id
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1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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