Cytokeratin 5 and cytokeratin 6 expressions are unconnected in normal and cancerous tissues and have separate diagnostic implications

  1. Völkel, Cosima
  2. De Wispelaere, Noémi
  3. Weidemann, Sören
  4. Gorbokon, Natalia
  5. Lennartz, Maximilian
  6. Luebke, Andreas M.
  7. Hube-Magg, Claudia
  8. Kluth, Martina
  9. Fraune, Christoph
  10. Möller, Katharina
  11. Bernreuther, Christian
  12. Lebok, Patrick
  13. Clauditz, Till S.
  14. Jacobsen, Frank
  15. Sauter, Guido
  16. Uhlig, Ria
  17. Wilczak, Waldemar
  18. Steurer, Stefan
  19. Minner, Sarah
  20. Krech, Rainer H.
  21. Dum, David
  22. Krech, Till
  23. Marx, Andreas H.
  24. Simon, Ronald ORCID logo
  25. Burandt, Eike
  26. Menz, Anne

Download
s00428-021-03204-4.pdf 1,26MB
WeightNameValue
1000 Titel
  • Cytokeratin 5 and cytokeratin 6 expressions are unconnected in normal and cancerous tissues and have separate diagnostic implications
1000 Autor/in
  1. Völkel, Cosima |
  2. De Wispelaere, Noémi |
  3. Weidemann, Sören |
  4. Gorbokon, Natalia |
  5. Lennartz, Maximilian |
  6. Luebke, Andreas M. |
  7. Hube-Magg, Claudia |
  8. Kluth, Martina |
  9. Fraune, Christoph |
  10. Möller, Katharina |
  11. Bernreuther, Christian |
  12. Lebok, Patrick |
  13. Clauditz, Till S. |
  14. Jacobsen, Frank |
  15. Sauter, Guido |
  16. Uhlig, Ria |
  17. Wilczak, Waldemar |
  18. Steurer, Stefan |
  19. Minner, Sarah |
  20. Krech, Rainer H. |
  21. Dum, David |
  22. Krech, Till |
  23. Marx, Andreas H. |
  24. Simon, Ronald |
  25. Burandt, Eike |
  26. Menz, Anne |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-09-24
1000 Erschienen in
1000 Quellenangabe
  • 480(2):433-447
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00428-021-03204-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986736/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Cytokeratins (CKs) 5 and 6 are functionally unrelated but often analyzed together using bispecific antibodies in diagnostic immunohistochemistry. To better understand the diagnostic utility of CK5 or CK6 alone, tissue microarrays with > 15,000 samples from 120 different tumor types as well as 608 samples of 76 different normal tissues were analyzed by immunohistochemistry. In normal tissues, both CKs occurred in the squamous epithelium; CK5 dominated in basal and CK6 in suprabasal layers. CK5 (not CK6) stained basal cells in various other organs. Within tumors, both CK5 and CK6 were seen in > 95% of squamous cell carcinomas, but other tumor entities showed different results: CK5 predominated in urothelial carcinoma and mesothelioma, but CK6 in adenocarcinomas. Joint analysis of both CK5 and CK6 obscured the discrimination of epithelioid mesothelioma (100% positive for CK5 alone and for CK5/6) from adenocarcinoma of the lung (12.8% positive for CK5 alone; 23.7% positive for CK5/6). CK5 and CK6 expressions were both linked to high grade, estrogen receptor, and progesterone receptor negativity in breast cancer (p < 0.0001 each), grade/stage progression in urothelial cancer (p < 0.0001), and RAS mutations in colorectal cancer (p < 0.01). Useful diagnostic properties which are commonly attributed to CK5/6 antibodies such as basal cell staining in the prostate, distinction of adenocarcinoma of the lung from squamous cell carcinoma and epithelioid mesothelioma, and identification of basal-type features in urothelial cancer are solely driven by CK5. At least for the purpose of distinguishing thoracic tumors, monospecific CK5 antibodies may be better suited than bispecific CK5/6 antibodies.
1000 Sacherschließung
lokal Female [MeSH]
lokal Diagnostic
lokal Immunohistochemistry
lokal Mesothelioma/pathology [MeSH]
lokal Keratin-6/analysis [MeSH]
lokal Humans [MeSH]
lokal Carcinoma, Transitional Cell/diagnosis [MeSH]
lokal Cytokeratin 6
lokal Tissue microarray
lokal Carcinoma, Squamous Cell/diagnosis [MeSH]
lokal Urinary Bladder Neoplasms [MeSH]
lokal Original Article
lokal Mesothelioma/diagnosis [MeSH]
lokal Keratin-5/analysis [MeSH]
lokal Male [MeSH]
lokal Cytokeratin 5
lokal Adenocarcinoma/diagnosis [MeSH]
lokal Biomarkers, Tumor/analysis [MeSH]
lokal Breast Neoplasms/pathology [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/VsO2bGtlbCwgQ29zaW1h|https://frl.publisso.de/adhoc/uri/RGUgV2lzcGVsYWVyZSwgTm-DqW1p|https://frl.publisso.de/adhoc/uri/V2VpZGVtYW5uLCBTw7ZyZW4=|https://frl.publisso.de/adhoc/uri/R29yYm9rb24sIE5hdGFsaWE=|https://frl.publisso.de/adhoc/uri/TGVubmFydHosIE1heGltaWxpYW4=|https://frl.publisso.de/adhoc/uri/THVlYmtlLCBBbmRyZWFzIE0u|https://frl.publisso.de/adhoc/uri/SHViZS1NYWdnLCBDbGF1ZGlh|https://frl.publisso.de/adhoc/uri/S2x1dGgsIE1hcnRpbmE=|https://frl.publisso.de/adhoc/uri/RnJhdW5lLCBDaHJpc3RvcGg=|https://frl.publisso.de/adhoc/uri/TcO2bGxlciwgS2F0aGFyaW5h|https://frl.publisso.de/adhoc/uri/QmVybnJldXRoZXIsIENocmlzdGlhbg==|https://frl.publisso.de/adhoc/uri/TGVib2ssIFBhdHJpY2s=|https://frl.publisso.de/adhoc/uri/Q2xhdWRpdHosIFRpbGwgUy4=|https://frl.publisso.de/adhoc/uri/SmFjb2JzZW4sIEZyYW5r|https://frl.publisso.de/adhoc/uri/U2F1dGVyLCBHdWlkbw==|https://frl.publisso.de/adhoc/uri/VWhsaWcsIFJpYQ==|https://frl.publisso.de/adhoc/uri/V2lsY3phaywgV2FsZGVtYXI=|https://frl.publisso.de/adhoc/uri/U3RldXJlciwgU3RlZmFu|https://frl.publisso.de/adhoc/uri/TWlubmVyLCBTYXJhaA==|https://frl.publisso.de/adhoc/uri/S3JlY2gsIFJhaW5lciBILg==|https://frl.publisso.de/adhoc/uri/RHVtLCBEYXZpZA==|https://frl.publisso.de/adhoc/uri/S3JlY2gsIFRpbGw=|https://frl.publisso.de/adhoc/uri/TWFyeCwgQW5kcmVhcyBILg==|https://orcid.org/0000-0003-0158-4258|https://frl.publisso.de/adhoc/uri/QnVyYW5kdCwgRWlrZQ==|https://frl.publisso.de/adhoc/uri/TWVueiwgQW5uZQ==
1000 Hinweis
  • DeepGreen-ID: 13d4a3802fce4d22bad94412673271ef ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6450034.rdf
1000 Erstellt am 2023-05-09T10:59:36.650+0200
1000 Erstellt von 322
1000 beschreibt frl:6450034
1000 Zuletzt bearbeitet 2023-10-21T02:38:27.665+0200
1000 Objekt bearb. Sat Oct 21 02:38:27 CEST 2023
1000 Vgl. frl:6450034
1000 Oai Id
  1. oai:frl.publisso.de:frl:6450034 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source